Solgar Inositol 500 mg Vegetable Capsules - Vitamin B8 - Vegan, Vegetarian, Kosher, 50 Count (Pack of 1)

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Studies show that inositol supplements can reduce these risks [ 26, 27]. It’s often prescribed by physicians for the management of gestational diabetes. 5. Inositol Can Reduce Acne and Hirsutism

Fertility - Lisi F, Carfagna P, Oliva MM, Rago R, Lisi R, Poverini R, Manna C, Vaquero E, Caserta D, Raparelli V, Marci R, Moscarini M Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study Reprod Biol Endocrinol. (2012 Jul 23) Tagliaferri V, Romualdi D, Immediata V, et al. Metformin vs myo-inositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study. Clin Endocrinol (Oxf). 2017;86(5):725–30. 10.1111/cen.13304Genazzani AD, Lanzoni C et al. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol. 2008 Mar;24(3):139-44.
15. Minozzi M, Costantino D et al. The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome. Gynecol Endocrinol. 2011 Nov;27(11):920-4. M.J., et al., Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocr Pract, 2002. 8(6): p. 417-23. R.S., Jr. and B. Darnell, Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr, 1980. 33(9): p. 1954-67. Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. (2023-Jan-26)

In a 2009 double blind clinical trial, 42 women with PCOS received myo-inositol (4 grams daily plus 400mcg folic acid) or placebo (folic acid alone). Results showed that myo-inositol increased insulin sensitivity, improved glucose tolerance and decreased glucose-stimulated insulin release. In addition, the researchers noted a positive effect on ovulation - 16 out of 23 women in the myo-inositol group ovulated, compared to 4 out of 19 women in the placebo group. In these women, there was also a 66% reduction of serum total testosterone and a 73% reduction of serum free testosterone concentrations. Cardiovascular markers, systolic and diastolic blood pressures, plasma triglycerides and total cholesterol concentrations also decreased in the myo-inositol group. 13 P.A. and A.E. Schindler, Myoinositol as a Safe and Alternative Approach in the Treatment of Infertile PCOS Women: A German Observational Study. Int J Endocrinol, 2016. 2016: p. 9537632. Periods: People with PCOS can have irregular periods or no periods at all. Treatment with inositols has been shown to help improve insulin sensitivity and reduce male hormone levels in females with PCOS. This helps restore periods.Myo-inositol is one supplement in particular which has received widespread attention for the potential role it has to play in supporting women with PCOS. And much research to date indicates that this novel supplement has the potential to provide support for many of these key areas.

A, Arslan S, Kocaadam B, Elibol E, İmamoğlu İ, Karadağ MG Effect of inositol and its derivatives on diabetes: a systematic review. Crit Rev Food Sci Nutr. (2019) What’s more, inositol may improve insulin’s action in women with polycystic ovary syndrome (PCOS), though the results are mixed ( 12, 13, 14). J., et al., Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome. Life Sciences, 2019. 236. Weight - Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D'Anna R One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome Climacteric. (2012 Oct) L.C., et al., Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev, 2017. 11(11): p. Cd003053.Combined Myo and D-chiro inositol: 4000 mg/day of myo-inositol + 100 mg/day of D-chiro inositol taken in two doses. Insulin resistance, a problem with your body’s ability to respond to insulin, is considered one of the key factors associated with conditions like metabolic syndrome ( 8). Another small study reported that 6 grams per day improved depression in 9 of 11 participants ( 23). Roseff S, Montenegro M. Inositol treatment for PCOS should be science-based and not arbitrary. Int J Endocrinol. 2020;6461254. doi:10.1155/2020/6461254