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But what is berberine? And is it safe? We spoke to Carolina Goncalves, superintendent pharmacist at Pharmica, to find out everything you need to know about the weight loss trend taking over TikTok. What is berberine?
Berberine for Weight Loss and Insulin Resistance – Cleveland Berberine for Weight Loss and Insulin Resistance – Cleveland
Suadoni MT, Atherton I Berberine for the treatment of hypertension: A systematic review. Complement Ther Clin Pract. (2021-Feb) We confirmed that Puritan’s Pride berberine supplements are vegan-friendly, and a small amount of vegetable magnesium stearate and silica are included, which are common fillers. This won’t hurt your health, but if you’re looking for a completely clean supplement, this one might not quite fit the bill. Lowering cholesterol. Studies have demonstrated that berberine may reduce low-density lipoprotein (LDL, or “bad”) cholesterol, total cholesterol and triglycerides.Yin, J., Xing, H., & Ye, J. (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism: Clinical and Experimental, 57(5), 712. Wang, X., Wang, Q., Liu, Z., & Zheng, X. (2017). Preparation, pharmacokinetics and tumour-suppressive activity of berberine liposomes. Journal of Pharmacy and Pharmacology, 69(6), 625-632. You may notice that obesity didn’t make the shortlist. That’s because there aren’t enough high-quality studies on the subject, though there has been some research showing that berberine supplementation may help reduce weight. What are the risks of berberine? Cai, Y., Xin, Q., Lu, J., Miao, Y., Lin, Q., Cong, W., & Chen, K. (2021). A New Therapeutic Candidate for Cardiovascular Diseases: Berberine. Frontiers in Pharmacology, 12. Kong WJ, Zhang H, Song DQ, Xue R, Zhao W, Wei J, Wang YM, Shan N, Zhou ZX, Yang P, You XF, Li ZR, Si SY, Zhao LX, Pan HN, Jiang JD Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism. (2009-Jan)
Berberine: Benefits, supplements, side effects, dosage, and more
Ai X, Yu P, Peng L, Luo L, Liu J, Li S, Lai X, Luan F, Meng X Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases. Front Pharmacol. (2021) When you take berberine as a pill or powder, it enters your bloodstream and travels to your cells, binding to different molecules. But instead of producing a single change, berberine interacts with multiple targets, impacting more than one disease at a time.
Canker Sores Symptoms - Jiang XW, Zhang Y, Zhu YL, Zhang H, Lu K, Li FF, Peng HY Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort Oral Surg Oral Med Oral Pathol Oral Radiol. (2012 Dec 12) However, it is important to remember that researchers have only studied berberine’s effects on cancer cells in a laboratory, not in people. Gut health Recently, a diabetes drug – that has been approved as a weight loss treatment in the UK (more on that here) – made headlines. Although the jab is used to treat Type 2 diabetes, as Goncalves explains: "Due to its ability to aid weight loss, it has been prescribed off-label to treat weight loss." The NCCIH advises people not to use goldenseal, which contains berberine, during pregnancy or while breastfeeding. They add that giving goldenseal to a newborn could trigger or worsen jaundice and increase the risk of kernicterus, a potentially life threatening condition. Berberine has an antibacterial action that seems to remove the harmful bacteria in the gut, and thus enhance the growth of healthy bacteria.