MAGNE B6 MAX - 50 Capsules - is a Dietary Supplement containing in its Composition Magnesium and Vitamin B6, for People Suffering Weakness, Fatigue, Twitching eyelids and Muscle spasms

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The reason why B6 may help prevent cancer is unclear, but researchers suspect that it’s related to its ability to fight inflammation that may contribute to cancer and other chronic conditions ( 34, 35). In 2010, the European Food Safety Authority (EFSA) published a review of proposed health claims for vitamin B 6, disallowing claims for bone, teeth, hair skin and nails, and allowing claims that the vitamin provided for normal homocysteine metabolism, normal energy-yielding metabolism, normal psychological function, reduced tiredness and fatigue, and provided for normal cysteine synthesis. [36] PLP is required for the conversion of tryptophan to niacin, so low vitamin B 6 status impairs this conversion. [15] Selenomethionine is the primary dietary form of selenium. PLP is needed as a cofactor for the enzymes that allow selenium to be used from the dietary form. PLP also plays a cofactor role in releasing selenium from selenohomocysteine to produce hydrogen selenide, which can then be used to incorporate selenium into selenoproteins. Hypersensitivity to any of the ingredients of Magne B6 medicine. Severe renal impairment with creatinine clearance less than 30 mg/min. When you are suffering from acute diseases in the gastrointestinal tract, undergoing a colectomy, ileostomy, intestinal obstruction, intestinal perforation, appendicitis, abdominal pain. When using the drug Magne B6 you need to be careful with the following:

Magnesium and vitamin B6 are said to be compatible with breastfeeding women. The recommended daily intake of vitamin B6 for lactating women is 20mg/day (equivalent to 4 tablets or 2 ampoules). The assessment of vitamin B 6 status is essential, as the clinical signs and symptoms in less severe cases are not specific. [39] The three biochemical tests most widely used are plasma PLP concentrations, the activation coefficient for the erythrocyte enzyme aspartate aminotransferase, and the urinary excretion of vitamin B 6 degradation products, specifically urinary PA. Of these, plasma PLP is probably the best single measure, because it reflects tissue stores. Plasma PLP of less than 10nmol/L is indicative of vitamin B 6 deficiency. [38] A PLP concentration greater than 20nmol/L has been chosen as a level of adequacy for establishing Estimated Average Requirements and Recommended Daily Allowances in the USA. [4] Urinary PA is also an indicator of vitamin B 6 deficiency; levels of less than 3.0mmol/day is suggestive of vitamin B 6 deficiency. [38] Other methods of measurement, including UV spectrometric, spectrofluorimetric, mass spectrometric, thin-layer and high-performance liquid chromatographic, electrophoretic, electrochemical, and enzymatic, have been developed. [38] [40] Vitamin B 6 is one of the B vitamins, and thus an essential nutrient. [1] [2] [3] [4] The term refers to a group of six chemically similar compounds, i.e., " vitamers", which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosphate, serves as a coenzyme in more than 140 enzyme reactions in amino acid, glucose, and lipid metabolism. [1] [2] [3] Hemoglobin is a protein that delivers oxygen to your cells. When you have low hemoglobin, your cells don’t get enough oxygen. As a result, you may develop anemia and feel weak or tired.a b c Joseph, Michael (10 January 2021). "30 Foods High In Vitamin B6". Nutrition Advance . Retrieved 17 August 2021. All nutritional values within this article have been sourced from the USDA's FoodData Central Database.

Magne B6 drug reduces the effect of tetracycline antibiotics and some other drugs such as Fluoroquinolones (Ciprofloxacin, Levofloxacin, Ofloxacin...), trientin... In case of need to be used together, the drugs should be taken separately. at least 3 hours apart. Avoid combining Magne B6 with drugs containing phosphates and calcium salts because these substances inhibit the absorption of magnesium in the small intestine. Do not take Magne B6 with Levodopa because vitamin B6 will reduce the effect of levodopa in the treatment of Parkinson's. However, if levodopa-carbidopa is used, this interaction does not occur. Magnesium crosses the placenta and the concentration of the drug in the placenta is equivalent to that in the blood. To date, there have not been many studies on the adverse effects of magnesium on the fetus. However, magnesium should only be used in pregnant women when clearly needed.Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions. It has health benefits for the body, including promoting brain health and improving mood. Following a recommendation of IUPAC-IUB in 1973, [53] vitamin B 6 is the official name for all 2-methyl,3-hydroxy,5-hydroxymethylpyridine derivatives exhibiting the biological activity of pyridoxine. [54] Moreover, pyridoxine alone should not to be used as a synonym of vitamin B 6. Zhang C, Luo J, Yuan C, Ding D (2020). "Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis". J Alzheimers Dis. 77 (2): 781–94. doi: 10.3233/JAD-200534. PMID 32773392. S2CID 221100310. Overview of Dietary Reference Intakes for Japanese" (PDF). Ministry of Health, Labour and Welfare (Japan). 2015 . Retrieved 19 August 2021. Jayedi A, Zargar MS (2019). "Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies". Crit Rev Food Sci Nutr. 59 (16): 2697–707. doi: 10.1080/10408398.2018.1511967. PMID 30431328. S2CID 53430399.

A controlled two-year study in approximately 300 older men who did not have depression at the start found that those taking a supplement with B6, folate (B9) and B12 were not less likely to have depressive symptoms compared to the placebo group ( 12).

Research shows that people with low blood levels of vitamin B6 have almost double the risk of getting heart disease compared to those with higher B6 levels ( 30).