Boswellia Serrata Extract 3000mg - 65% Boswellic Acid (150mg per Capsule) - Indian Frankincense - 60 Vegan Capsules (2 Months Supply)

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Sharma, M. L., Bani, S., and Singh, G. B. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int J Immunopharmacol. 1989;11(6):647-652. View abstract. Roy, S., Khanna, S., Krishnaraju, A. V., Subbaraju, G. V., Yasmin, T., Bagchi, D., and Sen, C. K. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. Antioxid.Redox Signal. 2006;8(3-4):653-660. View abstract. Notarnicola A, Maccagnano G, Moretti L, et al. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: randomized trial. Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6. View abstract. Roe AL, Wilcox R, Price JM, et al. An evaluation of potential inhibition of CYP3A4/5 and CYP2C9 enzymatic activity by Boswellia serrata extract. Applied In Vitro Toxicology. 2019; 5(1) doi.org/10.1089/aivt.2018.0023 Eshaghian R, Mazaheri M, Ghanadian M, Rouholamin S, Feizi A, Babaeian M. The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: a randomized, placebo-controlled, clinical trial. Complement Ther Med. 2019; 42:42-47. View abstract.

Badria FA, Mohammed EA El-Badrawy MK El-Desouky M. Natural leukotriene inhibitor from Boswellia: A potential new alternative for treating bronchial asthma. Alternative & Complementary Therapies 2004;10(5):257-265. In the future, this may make boswellia a helpful complementary treatment for asthma. For now, researchers need to focus on working toward studies in humans. Parkinson’s diseaseOsteoarthritis. Taking certain Boswellia serrata extracts alone or together with other ingredients can somewhat reduce pain and improve movement in people with osteoarthritis. Boswellia may stimulate blood flow in the uterus and pelvis. It can accelerate menstrual flow and may induce miscarriage in pregnant women. Sarkate, A., & Dhaneshwar, S. S. (2017). Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74. View abstract. To help provide Joint Comfort. Commonly known as Frankinsense, Boswellia Serrata is well known for its properties in supporting joint health and comfort and has also been shown to help maintain the structural integrity of connective tissues. The perfect partner to our Flex HA supplement, our high potency Boswellia extract, contains 65% Boswellic Acids, ensuring a highly effective product.

Sibona M, Destefanis P, Agnello M, Lillaz B, Giuliano M, Cai T, Gontero P. The association of Boswellia resin extract and propolis derived polyphenols can improve quality of life in patients affected by prostatitis-like symptoms. Arch Ital Urol Androl 2020;91(4):251-5. View abstract. Gupta I, Parihar A, Malhotra P, et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res 1997;2:37-43. View abstract. I thank Shao Kang Hung for doing the duplicate Jadad scores and Kate Boddy for the literature searches. Khan, M. A., et al. (2016). Pharmacological evidences for cytotoxic and antitumor properties of boswellic acids from boswellia serrata [Abstract]. Review methods All randomised clinical trials of B serrata extract as a treatment for any human medical condition were included and studies of B serrata preparations combined with other ingredients were excluded. Titles and abstracts of all retrieved articles were read and hard copies of all relevant articles were obtained. Selection of studies, data extraction and validation were done by the author. The Jadad score was used to evaluate the methodological quality of all included trials.Umar S, et al. (2014). Boswelliaserrata extract attenuates inflammatory mediators and oxidative stress incollagen induced arthritis. DOI: Buchele, B. and Simmet, T. Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 10-5-2003;795(2):355-362. View abstract.

Boswellia serrata is a tree native to India, Africa, and the Arabian Peninsula. It is commonly used in the traditional Indian medicine system, Ayurveda. Mehrzadi S, Tavakolifar B, Huseini HF, Mosavat SH, Heydari M. The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial. J Evid Based Integr Med. Jan-Dec;23:2515690X18772728. View abstract. Chande, N., McDonald, J. W., and Macdonald, J. K. Interventions for treating collagenous colitis. Cochrane.Database.Syst.Rev. 2008;(2):CD003575. View abstract. Desideri I, Lucidi S, Francolini G, et al. Use of an alfa-lipoic, methylsulfonylmethane, Boswellia serrata and bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management (AIA): a prospective phase II trial (NCT04161833). Med Oncol 2022;39(8):113. View abstract.Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 2001;67(5):391-395. doi:10.1055/s-2001-15802. One 2003 study published in the journal Phytomedicine found that all 30 people with OA knee pain who received boswellia reported a decrease in knee pain. They also reported an increase in knee flexion and how far they could walk.

Boswellia extracts showed some promise in treating asthma, 7 rheumatoid arthritis, 8 Crohn’s disease, 9 knee osteoarthritis, 10 12 13 and collagenous colitis. 11 However, all the included trials had flaws: the most common limitations were small sample size and incomplete reporting of data. The largest study included 102 patients, which is not large considering that this was a non-superiority trial. 9 Crucially, little independent replication was found; for only one of the five different indications (osteoarthritis) had more than one randomised clinical trial been published. 10 12 13 Calzavara-Pinton P, Zane C, Facchinetti E, et al. Topical Boswellic acids for treatment of photoaged skin. Dermatol Ther 2010;23:S28-32. View abstract. Belcaro G, Gizzi G, Pellegrini L, et al. Supplementation with a lecithin-based delivery form of Boswellia serrata extract (Casperome®) controls symptoms of mild irritable bowel syndrome. Eur Rev Med Pharmacol Sci 2017;21(9):2249-54. View abstract. Boswellia comes from the Boswellia serrata tree, which is native to India, North Africa, and the Middle East.Kulkarni PD, Damle ND, Hingorani L, et al. Pharmacokinetics of solid lipid Boswellia serrata particles in healthy subjects. Drug Metab Pers Ther 2021;36(3):215-21. View abstract. Sarkate A, et al. (2017). Investigation of mitigating effect ofcolon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonicacid-induced colitis in Wistar rats: Design, kinetics and biologicalevaluation. DOI: Galeone, G., Spadavecchia, R., Balducci, M. T., and Pagliarulo, V. [The role of Proxelan in the treatment of chronic prostatitis. Results of a randomized trial]. Minerva Urol.Nefrol. 2012;64(2):135-141. View abstract. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. View abstract. Roy, S., Khanna, S., Shah, H., Rink, C., Phillips, C., Preuss, H., Subbaraju, G. V., Trimurtulu, G., Krishnaraju, A. V., Bagchi, M., Bagchi, D., and Sen, C. K. Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells. DNA Cell Biol 2005;24(4):244-255. View abstract.