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An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans. New research, published in JAMA Network Open, suggests that the supplement, urolithin A, may help improve or prolong muscle activity in people who are aging or who have diseases that make exercise difficult. Wills ES, Jonkers DM, Savelkoul PH, Masclee AA, Pierik MJ, Penders J. Fecal microbial composition of ulcerative colitis and Crohn’s disease patients in remission and subsequent exacerbation. PLoS One. 2014;9:e90981. In any case, the lifespan of worms exposed to urolithin A increased by 45% compared to the control group. The company invested over a decade into research before commercializing its first product, Mitopure (the first clinically tested pure form of Urolithin A). Our primary focus for all these years has been to pioneer the pre-clinical and clinical trials with this novel molecule, Urolithin A. Both doses of urolithin A were associated with significant increases in leg strength, but the lower dose produced better results (+12% in the 500 mg group and +10% in the 1,000 mg group).
Sandhu AK, Miller MG, Thangthaeng N, Scott TM, Shukitt-Hale B, Edirisinghe I, et al. Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults. Food Funct. 2018;9:96–106. The price of Urolithin A supplements can vary widely depending on the brand, dosage, and additional ingredients. While it’s tempting to choose the most affordable option, consider the overall value, taking into account factors like dosage, quality, and reputation. Sometimes, a slightly higher-priced product may offer better quality and efficacy. 7. Monitor Your Body’s Response Before you jump toward filling up the shopping trolley with pomegranate juice, note that urolithins are only produced by certain types of gut flora, who participate in the digestion of ellagitannins. Their mainstay product “Mitopure”, is a Urolithin A supplement, brought to market in the culmination of more than ten years of scientific work, including capstone clinical trials in human subjects.
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Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, et al. The mitophagy activator Urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1:595–603. What they found instead was that pomegranate does legitimately have some health benefits. Those health benefits come from urolithin, which is found in high levels deep within the flesh of the plump, pink fruit. Researchers discovered that this one molecule can have powerful anti-aging effects.
As we age, our mitochondria lose their efficiency. There are many factors behind this. One of the most important is the accrual of errors in their mitochondrial DNA; meaning that all further cellular divisions from that mitochondrial will also be dysfunctional.Antioxidants: Some supplements include additional antioxidants like vitamin C or vitamin E to complement Urolithin A’s antioxidant properties. This can provide a synergistic effect for cellular protection. He added that urolithin A supplements could have potential to benefit people who cannot get the exercise they want due to poor muscle health or disease. Urolithin A is not found by itself but is a byproduct of gut bacteria breaking down certain foods containing Ellagitannins. These foods include raspberries, walnuts, pomegranates, and even drinks like cognac and whisky. However, only about 20% of people have the right gut flora to convert ellagitannins into urolithins.
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