Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

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Stijn Oste, CEO of Metagenics Europe , ​says: “We are very proud to be the first company to sign a partnership agreement with The Akkermansia Company.​

Lakshmanan AP, Kohil A, El Assadi F, Al Zaidan S, Al Abduljabbar S, Bangarusamy DK, Al Khalaf F, Petrovski G, Terranegra A. Akkermansia, a possible microbial marker for poor glycemic control in qataris children consuming arabic diet-A pilot study on pediatric T1DM in Qatar. Nutrients. 2021;13:836. The mucus layer is very important for gut health and for the health of your whole body. This could be a big reason why Akkermansia has been found to be so beneficial. While it chows down, Akkermansia produces nutrients that feed our other good gut bacteria. D isaccharides – "di" means two sugar, so a disaccharide comprises two sugar molecules bonded together. Sucrose is a disaccharide. It appears that the higher the level of Akkermansia, the better our resistance to a wide range of diseases Bertani B, Ruiz N. Function and biogenesis of lipopolysaccharides. EcoSal Plus. 2018;8:10.1128/ecosalplus.ESP-0001-2018.

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There are many different types of polyphenols. Some of them aren’t well absorbed by the body, and stay in the gut, which is good news for Akkermansia, who gobble the polyphenols up and supercharge their power as a result: a win/win. Oily fish

Nunez-Cordoba JM, Valencia-Serrano F, Toledo E, Alonso A, Martinez-Gonzalez MA. The Mediterranean diet and incidence of hypertension: the Seguimiento Universidad de Navarra (SUN) study. Am J Epidemiol. 2009;169:339–46. Tang WHW, Li DY, Hazen SL. Dietary metabolism, the gut microbiome, and heart failure. Nat Rev Cardiol. 2019;16:137–54.

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Lau WL, Kalantar-Zadeh K, Vaziri ND. The gut as a source of inflammation in chronic kidney disease. Nephron. 2015;130:92–8. Pushpakumar S, Kundu S, Narayanan N, Sen U. DNA hypermethylation in hyperhomocysteinemia contributes to abnormal extracellular matrix metabolism in the kidney. FASEB J. 2015;29:4713–25. Singh A, Zapata RC, Pezeshki A, Workentine ML, Chelikani PK. Host genetics and diet composition interact to modulate gut microbiota and predisposition to metabolic syndrome in spontaneously hypertensive stroke-prone rats. FASEB J 2019, 33:6748-66.

We know that Akkermansia like fish oil, but we don’t yet know if that means they like a specific component of the fish oil—for instance the fatty acids—or they like all of the parts together. So at the moment, it’s probably best to eat the fish. In the experiment mentioned earlier, the fish oil came from menhaden fish, which are not famed for their flavour and are usually used to make fish oil supplements. Though Akkermansia muciniphila is now available as a probiotic, it is also essential to take advantage of dietary factors that support the growth of this bacteria. The suitable organisms in our microbiome are often already there; they need nourishment like a lawn needs the suitable soil and fertilizer.The bacteria was first discovered, isolated and characterised from the human gut microbiota in 2004, in the laboratory of Prof. Willem M de Vos (Wageningen University, The Netherlands), a co-founder of A-Mansia. As a result, A. muciniphila has been shown to be more effective when it is dead vs. live. It is not alone in this effect; several lactic acid-producing probiotic organisms, such as Lactobacillus and Bifidobacter species, have also been effective when heat-killed. The effectiveness of these "zombie" or dead microbes is challenging the commercial dogma that the only effective probiotic bacteria live as expressed in colony-forming units (CFUs). That is not the case for A. muciniphila . What Makes Akkermansia muciniphila Important? Lau WL, Vaziri ND, Nunes ACF, Comeau AM, Langille MGI, England W, Khazaeli M, Suematsu Y, Phan J, Whiteson K. The phosphate binder ferric citrate alters the gut microbiome in rats with chronic kidney disease. J Pharmacol Exp Ther. 2018;367:452–60. Popular diets like the ketogenic and paleo diets are often deficient in foods promoting this vital organism. It may be necessary for these individuals to supplement their diet with prebiotics, flavonoid-rich extracts, fish oils , and concentrated forms of plant foods like spirulina , barley grass juice, and other green products.

Guevara-Cruz M, Flores-Lopez AG, Aguilar-Lopez M, Sanchez-Tapia M, Medina-Vera I, Diaz D, Tovar AR, Torres N. Improvement of lipoprotein profile and metabolic endotoxemia by a lifestyle intervention that modifies the gut microbiota in subjects with metabolic syndrome. J Am Heart Assoc. 2019;8:e012401. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2004;80:1012–8. However, if your diet isn’t as good as it could be, or you’re looking for a boost, high-quality supplements from natural sources can really help. For instance, research has shown that fish oil does boost Akkermansia levels Source: NCBI. When purified Amuc_1100 is given to mice it exerts the same effects as the live or heat-killed bacteria. The heat-killed bacteria produce better effects than the live form of A. muciniphila because it removes the exopolysaccharides coating but leaves the Amuc_1100 intact. Amuc_1100 then acts on cells that line the intestines to tighten up the space between the cells, reduce inflammation, and prevent the absorption of gut-derived toxins that lead to insulin resistance, non-alcoholic fatty liver disease, obesity, and type 2 diabetes. 1-6 A. muciniphila and Blood Sugar Control

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Hong YH, Nishimura Y, Hishikawa D, Tsuzuki H, Miyahara H, Gotoh C, Choi KC, Feng DD, Chen C, Lee HG, et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology. 2005;146:5092–9.