Gonge G-2117 Tactile Discs, Multicolour

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Gottschaldt KM, Vahle-Hinz C (1981) Merkel cell receptors: structure and transducer function. Science 214:183–186 Johnson KO (2001) The roles and functions of cutaneous mechanoreceptors. Curr Opin Neurobiol 11:455–461

Huang M, Chalfie M (1994) Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature 367:467–470

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DURABLE PLASTIC DISCS: As well as being strong enough to be grabbed and stepped on, they offer long-lasting durability for home and classroom use. With non-slip pads on the bottom of each plate, even on smooth surfaces, there is no need to worry about children falling over. Torebjork HE, Lundberg LE, LaMotte RH (1992) Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 448:765–780 Halata Z, Grim M, Bauman KI (2003) Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol 271:225–239 Sang CN, Gracely RH, Max MB, Bennett GJ (1996) Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism. Anesthesiology 85:491–496 Cavaletti G, Marmiroli P (2010) Chemotherapy-induced peripheral neurotoxicity. Nat Rev Neurol 6:657–666

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Ikeda I, Yamashita Y, Ono T, Ogawa H (1994) Selective phototoxic destruction of rat Merkel cells abolishes responses of slowly adapting type I mechanoreceptor units. J Physiol 479(Pt 2):247–256 Findlater GS, Cooksey EJ, Anand A, Paintal AS, Iggo A (1987) The effects of hypoxia on slowly adapting type I (SAI) cutaneous mechanoreceptors in the cat and rat. Somatosens Res 5:1–17

Khalsa PS, Friedman RM, Srinivasan MA, Lamotte RH (1998) Encoding of shape and orientation of objects indented into the monkey fingerpad by populations of slowly and rapidly adapting mechanoreceptors. J Neurophysiol 79:3238–3251 Senok SS, Baumann KI, Halata Z (1996) Selective phototoxic destruction of quinacrine-loaded Merkel cells is neither selective nor complete. Exp Brain Res 110:325–334 Baumann KI, Chan E, Halata Z, Senok SS, Yung WH (1996) An isolated rat vibrissal preparation with stable responses of slowly adapting mechanoreceptors. Neurosci Lett 213:1–4 Tapper DN (1965) Stimulus-response relationships in the cutaneous slowly-adapting mechanoreceptor in hairy skin of the cat. Exp Neurol 13:364–385 Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS et al (2007) Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer 110:2110–2118Hopkins HL, Duggett NA, Flatters SJ (2016) Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics. Curr Opin Support Palliat Care 10:119–128 Ikeda R, Ling J, Cha M, Gu JG (2015) In situ patch-clamp recordings from Merkel cells in rat whisker hair follicles, an experimental protocol for studying tactile transduction in tactile-end organs. Mol Pain 11:23 Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH et al (2003) Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 13:4477–4480 FOSTER PARENT-KID RELATIONSHIP: This sensory discs set strengthens the interaction between parents and children, increase the time spent together, and make the parent-child relationship more intimate.