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The Bio-Pilixin® Serum by Scandinavian Biolabs is a complete instant recovery serum expertly formulated to combat hair loss and stimulate new hair growth. Uniquely designed with multiple plant growth factors cultivated through advanced stem cell technology, this serum nourishes hair follicles and promotes healthy hair growth at the root. Topical SP-containing lotion to entire scalp daily for 24 wk; concentrated SP-containing serum to thinning areas daily for first 4 wk As men age, it is natural for them to lose some of their hair. This natural process occurs because of a hormone called dihydrotestosterone ( DHT), which is a by-product of the breakdown of testosterone. Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73. https://www.ncbi.nlm.nih.gov/pubmed/23298508

Significantly higher hair density scores (determined as > 0 indicating increased hair density from baseline) for finasteride (68%) versus SP (38%) In a clinical study, 93% of users reported satisfactory results regarding reduced hair shedding and encouraged hair growth. SP is well tolerated, and although it has not been associated with serious AEs in alopecia patients [ 16], more grave effects in other clinical settings have been described. Due to its hormonal effects, SP has the potential to cause gynecomastia [ 16], decrease libido [ 16], and reduce prostate serum antigen (PSA) levels, thereby necessitating vigilance not to miss early prostate cancer diagnosis [ 26]. Other reported AEs include rhinitis [ 16], intraoperative hemorrhage [ 44], hepatitis and pancreatitis [ 45, 46], loss of iris tone and intraoperative floppy-iris syndrome (IFIS) [ 47], and even 1 case of hypokalemia leading to cardiac arrest and death [ 16]. Further long-term studies are required for reliable safety assessment.A small RCT evaluated the efficacy of an oral tablet containing 200 mg of SP extract and an extra 50 mg of β-sitosterol (which has also been studied singularly for its antiandrogenic effects) versus placebo, taken twice daily in 26 men with mild to moderate AGA over 25 weeks. The primary endpoints of hair loss arrest and qualitative hair improvement were assessed objectively by researchers and subjectively by study participants via a standardized 7-point scale questionnaire. SP demonstrated 60% “improvement” in hair loss arrest and overall quality versus 11% among placebo. The active tablet also showed greater conservation of hair density and quality over time, as subjectively assessed by the study participants [ 19]. That said, studies suggest that saw palmetto supplements are generally safe for most people. The most common side effects include diarrhea, headache, fatigue, decreased libido, nausea, vomiting, and vertigo. Yet, they tend to be mild and reversible ( 21). Saw Palmetto seems like a promising treatment with few to no side effects. It is already available and can be used by anyone as a liposterolic extract in capsules, a liquid extract or can be consumed as tea. However, those who want to get the benefits of the plant’s fatty acids should know that they are not soluble in water and by consuming it as tea they might miss on some of its beneficial effects. What is 5-alpha reductase? Hair loss prevention: Saw palmetto may inhibit the enzyme 5-alpha reductase, which can reduce DHT levels, a hormone linked to hair loss. Patient-reported conservation of hair density and quality over time for the SP group versus placebo Significantly higher hair density scores (determined as > 0 indicating increased hair density from baseline) for finasteride (68%) versus SP (38%)

I am making this post to hopefully save some lives that would possibly be ruined over vanity, despite the odds.The researchers concluded that the saw palmetto group experienced a distinct increase in hair growth. When compared with the finasteride group, those treated with saw palmetto didn’t have spectacular results. Another difference between the two was the fact that finasteride acted both in the front area and the vertex while saw palmetto acted mostly in the vertex. PFS is very unique. I don't think there is any other condition that causes androgen insensitivity that isn't congenital. With their guidance, you can choose between pumpkin seed oil and saw palmetto based on your unique health needs and goals. FAQs Can I use both pumpkin seed oil and saw palmetto for hair loss? Hair mass and caliber significantly improved by 20% at 10 wk and 30% at 50 wk using SP-containing lotion versus vehicle (10% decrease to 8% increase, respectively) By the end of the study, about one-third of those given saw palmetto reported an increase in hair growth. That said, saw palmetto was only half as effective as the conventional medication ( 17).

Interactions may occur between saw palmetto and some other medications. Because it’s been shown to thin blood, saw palmetto should never be taken simultaneously with other blood thinners. In particular, it shouldn’t be taken with aspirin and prescriptions such as warfarin. For this reason, some men who have prostate cancer take supplements of saw palmetto in addition to traditional treatment.

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The largest RCT to date compared oral 320-mg SP-containing tablets versus 1-mg finasteride daily in 100 men with AGA over 2 years. Measurement of hair density was assessed by standardized global photography; the effectiveness of the treatment was evaluated with a 7-point clinical score scale as determined by 3 expert dermatologists experienced in the field of alopecia. Notably, 68% of patients treated with finasteride had higher hair density scores from baseline as compared to 38% of the SP group ( p< 0.05), indicating that SP is inferior to finasteride. Although neither treatment was reported to be clinically effective in 10% of patients, SP had stabilized progression of AGA in 52% of cases [ 20]. Improved hair pull test at 1,3, and 6 mo (9.8, 7.5, and 6.5%, respectively) for SP versus placebo (11.9, 10.7, and 8.8%, respectively) The vast majority of data pertaining to SP's efficacy, antiandrogenic properties in vitro, and side-effect profile are derived from studies on BPH [ 8, 9] and treatment of urinary symptoms in vivo [ 3, 4, 5]. However, many of these findings have been called into question, given subsequent trials showing no effects on androgen-dependent parameters when SP is compared to traditional antiandrogenic agents such as finasteride [ 12, 13]. Despite numerous reports regarding SP's clinical efficacy, comprehensive meta-analyses have failed to demonstrate significant improvement in BPH symptoms or objective disease parameters, thus casting doubt on SP's previously attributed antiandrogenic properties [ 14, 15]. They are for conditioning and nourishing the hair. That means they sink into the hair strand and help improve its health, rather than coating them as serums do. It grows in sandy soil and gets its name from the sharp, saw-like teeth on the stalks that attach the tree’s leaves to its stem. The saw palmetto tree produces dark berries that contain a large seed ( 1).