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Porter, J. A. et al. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363–366 (1995).

Measurements were performed using a Prometheus NT.48 instrument (NanoTemper Inc., Germany). ShhN was diluted to 0.2 mg/mL in buffer contained 10 mM HEPES, pH 7.4, 150 mM NaCl, and 5% DMSO. Measurements were carried out using 70% power with standard Prometheus NT.48 capillaries. The heating was 1.0°C/min from 20 to 95°C. Results and Discussion Discovery of ShhN–Ptch PPI Inhibitors Mohler, J. & Vani, K. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957–971 (1992). Chamoun, Z. et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293, 2080–2084 (2001). Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003;3(12):903–11.

Acknowledgments

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Kastl, P. et al. Disrupting Hedgehog Cardin-Weintraub sequence and positioning changes cellular differentiation and compartmentalization in vivo. Development https://doi.org/10.1242/dev.167221 (2018).

Pak E, Segal RA. Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy. Dev Cell. 2016;38(4):333–44. Chen, J. K. I only have eye for ewe: the discovery of cyclopamine and development of hedgehog pathway-targeting drugs. Nat. Prod. Rep. 33, 595–601 (2016). Long, T. et al. Structural basis for itraconazole-mediated NPC1 inhibition. Nat. Commun. 11, 152 (2020).

Luchetti, G. et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. Elife https://doi.org/10.7554/eLife.20304 (2016). Oxidized cholesterol derivatives that can result from enzymatic synthesis or chemical oxidation. Protein self-splicing We offer cute, fun insect houses that provide a safe place for our tiny friends to live and thrive.

Results and Discussion

Teglund S, Toftgård R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta. 2010;1805(2):181–208. Basset-Séguin, N. et al. Vismodegib in patients with advanced basal cell carcinoma: primary analysis of STEVIE, an international, open-label trial. Eur. J. Cancer 86, 334–348 (2017). For reasons of hygiene and safety, personal grooming products, cosmetics or items of intimate clothing cannot be returned.