Turmeric Powder (500g, 1.1 lb), Curcuma 100% Natural, min. of 3% curcuminoids Laboratory Tested, Gently Dried and Ground Turmeric Root, No additives, Vegan

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Gallbladder problems: Turmeric can make gallbladder problems worse. Do not use turmeric if you have gallstones or a bile duct obstruction. Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects of talinolol. High doses of curcumin may cause mild side effects in some people, but it is generally considered safe. The long-term effects of taking curcumin in humans are unknown.

Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138(2):212-222. View abstract. Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., Marczylo, T. H., Morgan, B., Hemingway, D., Plummer, S. M., Pirmohamed, M., Gescher, A. J., and Steward, W. P. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 10-15-2004;10(20):6847-6854. View abstract. Rafatullah, S., Tariq, M., Al Yahya, M. A., Mossa, J. S., and Ageel, A. M. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol. 1990;29(1):25-34. View abstract.

Turmeric and Ulcerative Colitis

Hay fever. Taking turmeric by mouth seems to reduce hay fever symptoms such as sneezing, itching, runny nose, and congestion. Kanai, M., Imaizumi, A., Otsuka, Y., Sasaki, H., Hashiguchi, M., Tsujiko, K., Matsumoto, S., Ishiguro, H., and Chiba, T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother.Pharmacol 2012;69(1):65-70. View abstract.

Peschel, D., Koerting, R., and Nass, N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr.Biochem. 2007;18(2):113-119. View abstract. Kumar, A., Purwar, B., Shrivastava, A., and Pandey, S. Effects of curcumin on the intestinal motility of albino rats. Indian J Physiol Pharmacol 2010;54(3):284-288. View abstract. Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., and Kong, L. D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog.Neuropsychopharmacol.Biol.Psychiatry 4-30-2009;33(3):435-449. View abstract. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J Ethnopharmacol. 9-25-2007;113(3):479-486. View abstract. Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54(11):3452-3464. View abstract.

Anti-Cancer Effects

Rasyid, A. and Lelo, A. The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Aliment.Pharmacol Ther. 1999;13(2):245-249. View abstract. Turmeric might increase how much sulfasalazine the body absorbs. Taking turmeric while taking sulfasalazine might increase the effects and side effects of sulfasalazine. Smith, M. R., Gangireddy, S. R., Narala, V. R., Hogaboam, C. M., Standiford, T. J., Christensen, P. J., Kondapi, A. K., and Reddy, R. C. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am.J Physiol Lung Cell Mol.Physiol 1-8-2010; View abstract.

Kuo, M. L., Huang, T. S., and Lin, J. K. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim.Biophys.Acta 11-15-1996;1317(2):95-100. View abstract.

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Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14(30):4753-4762. View abstract. While curcumin has a very good safety profile, some research suggests it may affect how your body processes certain medications, including ( 24, 33, 34): Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20(8):2549-2551. View abstract. Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35(5):599-606. View abstract. Patel, S. S., Shah, R. S., and Goyal, R. K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp.Biol. 2009;47(7):564-570. View abstract.

Extremely high doses of 1,170 mg per pound (2,600 mg/kg) of body weight daily for 13 weeks, or up to 2 years, may cause some serious side effects in rats. These include an increase in liver size, stained fur, stomach ulcers, inflammation, and an increased risk of intestinal or liver cancer ( 32). Kusuhara, H., Furuie, H., Inano, A., Sunagawa, A., Yamada, S., Wu, C., Fukizawa, S., Morimoto, N., Ieiri, I., Morishita, M., Sumita, K., Mayahara, H., Fujita, T., Maeda, K., and Sugiyama, Y. Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br J Pharmacol 2012;166(6):1793-1803. View abstract. Satoskar, R. R., Shah, S. J., and Shenoy, S. G. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int.J Clin Pharmacol Ther.Toxicol. 1986;24(12):651-654. View abstract.There are no official recommendations for the intake of turmeric, and the maximum tolerable intake level has not been identified. Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol.Microcirc. 2006;35(4):481-489. View abstract. Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227(1):115-124. View abstract. Pavithra, B. H., Prakash, N., and Jayakumar, K. Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. J Vet.Sci. 2009;10(4):293-297. View abstract.