About this deal
Kane, J.; Honigfeld, G.; Singer, J.; Meltzer, H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch. Gen. Psychiatry 1988, 45, 789–796.
Several researchers have also commented on the importance of dosage. 97 Indeed, Blewett 98 warned that giving participants low doses of LSD may not be sufficient to break through the barrier between the normal and the full-blown psychedelic state, and as a result be merely disorientating rather than transformative. Support for this logic is also evident in escalating dose research with DMT. 99 It is additionally advised that experienced participants control their own dosage, 100 as in the experiment by Wezelman and Bierman. 101 Participants’ self-reports of the depth of the altered state were considered better than dosages as indicators of subjective effects. 102 Self-reports using the Hallucinogenic Rating Scale were seen to be more accurate indicators of dosage than physiological measures, 103 though the use of a scale of transpersonal experience, such as the Self-Expansiveness Scale Form, 104 would also likely be fruitful in discerning the relevant depth of the psychedelic state of consciousness. Furthermore, some researchers, 105 have noted that the issue of dosage is largely irrelevant in comparison to the influence of the psychological factors of set and setting, as originally noted in psychedelic research by Leary, Litwin, and Metzner. 106 In discussion of this, Vayne 107 suggested that the influence of psychological factors on psychoactive drugs can vary their effects so much that the drug can be thought of primarily as an experience, composed of set, setting, and substance.Grob extolled the desirability of "using these substances in sanctioned, approved clinical settings." He emphasized that the development
wonder that the literature and with it the psychedelic substances themselves have gained an unsavory reputation in academic circles and that by
Well before 1960centers of LSD-activity were springing up everywhere. Oscar Janiger gave sessions in little cubicles in his office in Los