The Poetic Mind

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Survival and hepatic inflammation are significantly altered in AKBI mice following I/R, but not LPS-mediated injury.

Born in Paddington, to a British-Jamaican family, Abbott attended Harrow County School for Girls before reading History at Newnham College, Cambridge. After joining and leaving the Civil Service, she worked as a reporter for Thames Television and TV-am before becoming a press officer for the Greater London Council. Joining the Labour Party, she was elected to Westminster City Council in 1982 and then as an MP in 1987, being re-elected in every general election since. Profile: Diane Abbott". BBC News. 9 June 2010. Archived from the original on 27 September 2018 . Retrieved 20 June 2018. The 69-year-old MP had the Labour whip withdrawn in April after she suggested that Jewish, Irish and Traveller people were not subject to racism “all their lives”, in a letter to the Observer. Does she not appreciate how insulting her words and views are to many Jews in this country, as well as to the memory of millions who suffered at the hands of racism throughout the world?Watts, Joe (6 June 2017). "Diane Abbott pulls out of Woman's Hour election debate with Amber Rudd after another bungled interview". The Independent. Archived from the original on 6 June 2017 . Retrieved 6 June 2017. Stratton, Allegra (9 June 2010). "David Miliband keeps Diane Abbott in Labour leadership race". The Guardian. London. Archived from the original on 5 April 2017 . Retrieved 11 December 2016. Shelf Life: Diane Abbott". www.penguin.co.uk. 29 July 2019. Archived from the original on 4 September 2019 . Retrieved 4 September 2019. Diane Abbott is quite staggering in her wilful and woeful comments. As an MP for one of the largest Jewish constituencies in the country, and as a history graduate, how can she be unaware of the history of the Jewish people, millions of whom suffered unspeakable racism in one century alone, let alone over the millennia? She adds: “This completely undermines any idea that there is fairness or any natural justice. It is procedurally improper.

Brown, David; Dominic Kennedy (17 September 2015). "Jeremy Corbyn and Diane Abbott were lovers". The Times. Archived from the original on 25 December 2015 . Retrieved 30 January 2016. Abbott's speech on civil liberties, in the debate on the Counter-Terrorism Bill 2008, [13] won The Spectator magazine's "Parliamentary Speech of the Year" award, [14] and further recognition at the 2008 Human Rights awards. [15] A speech by Abbott in a House of Commons debate on the Caribbean is included in Margaret Busby's 2019 anthology New Daughters of Africa. [16] [17] a b c Bush, Stephen (9 September 2021) [17 January 2017]. "Having the last laugh". New Statesman. Archived from the original on 31 August 2022 . Retrieved 15 May 2023. Less famous places give me much more pleasure because they are uncrowded, but even mentioning them publicly makes me feel I’m dooming them to a similar demise.

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One consequence has been the entrenchment of what we now call “identity politics”. As hopes for social change have eroded, many have clung ever more fiercely to their own communities as places of safety and shelter. The more one hunkers down in separate laagers, the more the laager becomes the only way through which to perceive the world, and the bigger one’s race or identity looms in one’s consciousness. Antiracism has come to be more fragmented, more inward looking and viewed more as a kind of zero-sum struggle in which the interests of one group are set off against those of another. She added: “Others have committed far more grave offences, and belated or grudging apologies have been wrung from them. Yet they have been immediately excused as supporters of his leadership.” In August 2018, Abbott complained that there were still delays in settling Windrush claims, saying: "From the Windrush scandal to immigration detention, to these outrageous delays – it is long past time that the government takes responsibility for leaving people distressed and destitute." [103] Comments about Mao Zedong [ edit ]

Neutrophil recruitment and liver dysfunction following liver I/R, but not LPS challenge, is significantly attenuated in AKBI mice. (A) Liver tissues from ABKI and WT littermates were evaluated for histopathology in paraffin sections following LPS or I/R treatment. Livers from LPS-injected (4 μg/g body weight, i.v.) or I/R-treated (1 hour ischemia) mice were harvested at 18 hours after LPS treatment or reperfusion, respectively. Tissue samples were then fixed with 10% neutral formalin and embedded in paraffin for sectioning. Photomicrographs depict high-power (×400) and lower (×100) power representative photomicrographs for both AKBI and WT littermates for the indicated conditions. The high-power photomicrograph is an enlargement of the lower power field given for each example. (B) Hepatic neutrophil accumulation in WT and AKBI mice at 18 hours after reperfusion was quantified by measuring liver MPO activity. Values represent the mean (± SEM) for n= 4 independent animals in each group. (C) AKBI mice were compared to WT mice for liver function following I/R at the indicated time points. Values depict ALT levels (mean ± SEM) as an index for liver injury from n= 4 animals for each experimental point. Differences marked by daggers in B are statistically significant by the Student’s t test ( P< 0.05). ALT profiles were also significantly different between AKBI and WT mice ( P< 0.05) as assessed by ANOVA.a b Coates, Sam (3 June 2017). "Labour frontbench fury as Diane Abbott goes rogue". The Times. Archived from the original on 3 June 2017 . Retrieved 6 June 2017. (subscription required) Allegretti, Aubrey (24 February 2020). "Diane Abbott to step down from shadow cabinet". Sky News . Retrieved 20 November 2020. This is what some have clearly wanted all along. Taken together, the procedural impropriety, Starmer’s pronouncement of my guilt, the four-month delay in the investigation, the repeated refusal to try to reach any accommodation, all point in the direction that the verdict has already been reached. The crushing of democracy in my local Labour party is the latest confirmation.” Differences in the mechanisms of LPS and I/R injury may account for the evolutionarily diverged functions of IκBα and IκBβ in regulating NF-κB activation. For example, the induction of NF-κB following liver I/R injury is regulated by acute redox-activated responses that seem to involve NADPH oxidase ( 42). Clearance of these superoxides attenuate NF-κB activation and inhibit liver injury following I/R ( 25). Although TNF-α has been implicated in the hepatic I/R injury process during the subacute phases of injury ( 43), the levels of TNF-α produced in the setting of I/R injury are much less than those following LPS injury. Proinflammatory stimuli, such as LPS and TNF-α, also activate NF-κB through ligand–receptor interactions in a manner that is different from redox acute activation of NF-κB following I/R injury. Additionally, proinflammatory models of acute inflammation, such as carrageenan-induced pleurisy, have suggested that NF-κB activation plays an important role not only in activating proinflammatory cytokine cascades (such as TNF-α) that lead to inflammation, but also in resolving the resulting inflammation through anti-inflammatory pathways and leukocyte apoptosis ( 24). When considering injury context–specific mechanisms of NF-κB activation, it is important to appreciate that NF-κB must work in concert with other signaling pathways that ultimately determine the response of a given organ to injury. In the context of I/R injury, c-Src is uniquely positioned to respond to redox-mediated stimuli in a receptor-independent fashion ( 30, 44). Several groups have identified Src family tyrosine kinases involved in phosphorylating IκBα in addition to c-Src. For instance, spleen tyrosine kinase mediates IκBα tyrosine phosphorylation following hydrogen peroxide treatment in human myeloid KBM-5 cells ( 45). Thus, c-Src activation following liver I/R may act as a redox sensor for NF-κB activation. Such pathways of NF-κB activation seem to be fundamentally different from those involved in proinflammatory assaults such as LPS, which mediate NF-kB activation through the canonical IKK-mediated pathway. Abbott’s letter said that Irish, Jewish and Traveller people “undoubtedly experience prejudice”, but added: “This is similar to racism and the two words are often used as if they are interchangeable.”