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As the sets progressed and the weights increased, I did notice something: I was breathing just as hard as ever, but my legs still felt primed for more. Call it a fluke. Call it a placebo. IDK, but the fatigue I would normally experience just wasn’t there, particularly in my calves. Comments requesting medical advice will not be responded to, as I am not legally permitted to practice medicine over the internet. The current study was designed to explore the effectiveness of PR Lotion as a transdermal delivery vehicle for sodium bicarbonate to skeletal muscle under a resting condition. According to the manufacturer, PR Lotion’s ingredients encapsulate hydrophilic molecules (e.g., sodium bicarbonate) for paracellular delivery, penetrate the stratum corneum, disrupt the junctional proteins of the skin barrier, and transiently create a paracellular pathway for the local delivery of molecular substances into the underlying tissues. While we did not directly test these claims, consistent with our hypothesis, the increase in pH of the intramuscular dialysate and serum are in support of PR Lotion’s proposed function. Indeed, the 0.13 increase in pH in dialysate from a baseline of 6.85 translates to a ∼28% reduction in [H +]. Changes in serum pH were smaller (∼9% reduction in [H+]) yet consistent with the anticipated alkalotic effect of PR Lotion application, increasing pH. Early work by Costill et al., ( Costill et al., 1984), found that oral sodium bicarbonate could reduce metabolic acidosis in response to repeated bouts of supramaximal cycling and this was associated with improvements in cycling performance. Since then, the use of oral sodium bicarbonate as an ergogenic aid has produced mixed results due in part to differences in dosing practices, exercise models, acute ingestion versus chronic loading, and variation in gastrointestinal tolerance ( Carr et al., 2011; Calvo et al., 2021).
Siegler, J.C., et al., Mechanistic Insights into the Efficacy of Sodium Bicarbonate Supplementation to Improve Athletic Performance. Sports Med Open, 2016. 2(1): p. 41. Comments containing language or concepts that could be deemed offensive will be deleted. Note this may include abusive, threatening, pornographic, offensive, misleading or libelous language. PR Lotion is the first and only topical lotion to deliver sodium bicarbonate directly through the skin. This enhances the buffering capacity of the body and the muscle while circumventing the potentially debilitating GI distress. In addition, PR Lotion removes much of the complexity required in pre-exercise ingestion protocol or strategies. In contrast to ingested sodium bicarbonate, there is little need for athletes to incorporate tedious pre-exercise protocols, strategies, or routines to combat negative side effects. This makes PR Lotion a very practical solution for delivering the performance benefits of sodium bicarbonate and a very scalable solution for athletes to use regularly during training and competition. PR Lotion effectively eliminates all problems associated with the ingestion of sodium bicarbonate, while providing athletes with the benefits described in over 40 years of sodium bicarbonate research. The studies involving human participants were reviewed and approved by the Institutional Review Board at the University of Oregon. The patients/participants provided their written informed consent to participate in this study. Author contributions In the short intensity series, blood lactate and pH were measured and compared 14 times. In the long intensity session, HR and RPE were each measured and compared five times. Each one of these time points is an opportunity to find a P value <0.05 or a significant difference between the treatment and placebo. As I’ve written before, when a study reports results of multiple outcomes and multiple exposures, it increases the probability that at least some of those results may be statistically significant even though there is no underlying effect.
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One user states: “Most weeks I would race Tuesday/Wednesday/Thursday. Crazy? Not with this stuff. I can go hard on the bike day after day. Never getting that soreness that forced me to rest. I also used to struggle with leg cramps and while I still get them sometimes, using PR lotion has drastically reduced them.” Final ThoughtsDr. Jason Siegler (University of Western Australia) examined the effect of PR Lotion on blood lactate concentration and performance outcomes with repeated 30 second cycling intervals at 120% of peak power (30 second rest) to exhaustion. A similar rise in blood lactate levels was observed compared to oral sodium bicarbonate ingestion (standard dose of 0.3g/kg body weight). Although the study did not observe the typical increase in blood bicarbonate (or increase in blood pH) usually associated with sodium bicarbonate ingestion, the results suggest PR Lotion was as effective as ingesting sodium bicarbonate at buffering H+ production in the muscle at high intensities. Furthermore, the cyclists performed similarly (defined by cumulative cycling time) compared to oral sodium bicarbonate ingestion. Similar performance outcomes, combined with the observation that blood lactate values were similar, suggests PR Lotion is an effective ergogenic aid during high intensity or repeated bouts of high intensity exercise. One of the limitations to a white paper like this is that it’s a good example of the sharpshooter fallacy. The term refers to the story of a Texan who shoots holes in the side of the barn and then draws targets around the bullet holes. Another way to put it: it’s important to call your shots before you take them. Trials often presented as hypothesis-testing are actually hypothesis-generating because of this bias.
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