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ProHealth Longevity Pure NMN Pro Powder - Uthever Brand - World’s Most Trusted, Ultra-Pure, stabilized, Pharmaceutical Grade NMN to Boost NAD+, Used in Human Clinical Research Trials (15 Grams)

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Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin. NMN products, including our NMN Pro capsules, are shown to support health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in metabolism, energy production, and gene expression in the body. NMN is a natural metabolite of vitamin B3 and a precursor to NAD+ which supports myriad functions essential to health and healthy aging. NAD+ levels decline in human tissue by at least 50 percent between the ages of 40 and 60. Taking NMN boosts natural NAD+ production, and provides the body with energy for gene repair and stimulation. Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression. TMG, also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. These processes are known to decline with age and may also be affected by common gene mutations. Also, NMN supplementation may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity.* There are 30 servings per container, but each dose requires two capsules. That means you can titrate up from a lesser dose or simply take one capsule per day to provide a 450mg dose that’s higher than many other companies offer but may offer a better safety profile for some people than 900mg.

During a meeting on Friday, Dan Fabricant, the head of the Natural Products Association (the NPA) explained that although everyone hopes the citizen's petition leads to an FDA policy reversal on NMN, the filing is meaningful regardless of the FDA's response because it will ultimately allow the trade organizations the right to sue the FDA. Now that the citizen's petition has been filed the FDA has 180 days to respond. Often, they don't respond to citizen's petitions, but in both the case of a denial of the petition or a non-response the NPA and ANH gain the legal right to sue. Stresses Dayton, "We have integrity. We care about people's health. It is essential for us to call attention to this dire situation, so that our industry and consumers can be assured they are getting stable, authentic, pure and safe NMN." Effepharm's clinical trials Most people will probably be surprised to learn that the way the FDA determines if a new ingredient should be classified as a drug or as a supplement is simply based on who files the paperwork first. NMN has been sold as a supplement for about 10 years in the US. Over the years, a few supplement companies have sent the necessary paperwork to the FDA to have NMN classified as a supplement, but each time the submission was rejected for unknown reasons. Then, a pharmaceutical company submitted the paperwork to have a refined form of NMN classified as an investigational drug and it was approved. After that, several supplement companies submitted the paperwork to have NMN classified as a supplement and at least one was approved. However, the FDA later retracted that supplement approval and changed the earlier designation of the refined form of NMN as a drug to include all forms of NMN as a drug. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521 Jiang, Y., Luo, Z., Gong, Y., Fu, Y., & Luo, Y. (2023). NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling. Oncogene, 42(11), 808-824.Last week, two of the largest supplement and natural products trade organizations filed a citizen's petition with the FDA asking that they change their position on NMN. The Natural Products Association (NPA) and the Alliance for Natural Health (ANH) asked the FDA to: In addition to that real-world experience with NMN, our team has pored over dozens of scientific journal articles devoted to NAD production and NMN metabolism. All of this preparation allows us to confidently suggest which available supplements stand the best chance of increasing your NAD levels. Caution: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your health care provider before using this product. Consumer-facing dietary supplement retailers don't typically become ingredient suppliers. But in 2019, after renowned Harvard University researcher Dr David Sinclair's heavily publicised research on the anti-ageing benefits of NMN, the ingredient became wildly popular.

The Uthever Research and Development Team is led by U.S. doctors from GlaxoSmithKline , a research-based pharmaceutical and healthcare company that has established itself as a world-class leader in both medicine and healthcare. According to information released by Effepharm: More than half of the NMN products tested contained zero NMN and some products had less than 80 percent purity. There were suppliers selling ordinary nicotinamide (low-cost vitamin B3) as NMN. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985 Supplement Facts Hopefully the FDA ultimately limits the drug classification to the refined form of NMN, but we won’t know until the FDA takes any enforcement action.NAD and sirtuin activity go hand-in-hand, with the former dependent on the latter for regulating cellular energy and signaling pathways associated with aging. 19 And resveratrol has repeatedly been shown to activate sirtuin 1 (SIRT1). 20 It also boasts cardioprotective, neuroprotective, and cancer-fighting benefits. 11 By combining NMN with resveratrol, you can theoretically increase SIRT1 and improve on its potential by doing so in the presence of additional NAD. 21 The U.S. Pharmacopoeia (USP) is a globally recognized quality standards agency that establishes standards for pharmaceutical development and manufacturing. Effepharm has recently completed a multi-center, randomised, double-blind, parallel design, placebo-controlled study to evaluate the efficacy and safety of its Uthever NMN, which is manufactured in strict accordance with USP standards. Compared to NAD, NMN is a smaller molecule and can more easily pass through cell membranes. That makes it far superior to direct supplementation with NAD, which the body can scarcely absorb.

Suggested Use: Take 2 capsules daily, with or without food, preferably in the morning, or as directed by your healthcare practitioner.

Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013 Ramírez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Muñoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdú-Queralt, A., & Lamuela-Raventós, R. M. (2018). Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients, 10(12). Now, in addition to selling Uthever NMN direct to consumers, ProHealth Longevity is the authorised distributor to the industry worldwide with exclusive trademark rights in the US." The partnership makes sense. ProHealth Longevity is celebrating 33 consecutive years as a Better Business Bureau A+ rated company known for providing the highest quality supplements. Effepharm is a leading global biotechnology manufacturer serving pharmaceutical, nutrition and healthcare industries, to provide our customers with the world's best NMN. NMN One promising ingredient in NAD+ Gold is trimethylglycine (TMG). This ingredient is known as a methyl donor, meaning that it can provide the carbon and hydrogen necessary for methylation. NAD activity and methylation are interdependent processes that the presence of TMG can improve. 18 NAD+ Gold contains 50mg each of NMN and TMG.

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