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GALPHARM Loratadine 10mg Hayfever and Allergy Relief One-a-Day Tablets 14's

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In a 35-day study in children aged 5 to 12, no tolerance to the antihistaminic effect (suppression of wheal and flare) of cetirizine was found. When a treatment with cetirizine is stopped after repeated administration, the skin recovers its normal reactivity to histamine within 3 days. Used for the relief of hay fever and allergies, Galpharm cetirizine hydrochloride tablets help to prevent symptoms for up to 24 hours. Patients with moderate to severe renal impairment: there are no data to document the efficacy/safety ratio in patients with renal impairment. Since cetirizine is mainly excreted via renal route (see section 5.2), in cases no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to the following table and adjust the dose as indicated. To use this dosing table, an estimate of the patient’s cre­atinine clearance (CLcr) in ml/min is needed. The CLcr (ml/min) may be estimated from serum creatinine (mg/dl) determination using the following formula:

Galpharm One-a-Day STORING THE MEDICINE Allergy and Hayfever Galpharm One-a-Day STORING THE MEDICINE Allergy and Hayfever

Cetirizine does not undergo extensive first pass metabolism. About two third of the dose are excreted unchanged in urine. The terminal half-life is approximately 10 hours. Galpharm antihistamine tablets do not cause drowsiness in most people. However, as with other antihistamines, rare cases of drowsiness have been reported. If affected do not drive or operate machinery. As with all antihistamines, you should avoid excessive alcohol consumption when taking this medicine. Can you take Galpharm Cetirizine and Hydrochloride tablets when pregnant or breastfeeding?

Side Effects

Rare: hepatic function abnormal (increased transaminases, alkaline phosphatase, y-GT and bilirubin) Do not exceed the stated dose when taking Galpharm Hay fever and Allergy Relief Cetirizine Hydrochloride. If symptoms persist whilst taking this medication, consult your doctor. Caution should be taken in patients with predisposition factors of urinary retention (e.g. spinal cord lesion, prostatic hyperplasia) as cetirizine may increase the risk of urinary retention.

Allergy Relief 30 Pack - Tesco Groceries Treathay Allergy Relief 30 Pack - Tesco Groceries

History of hypersensitivity to any of the constituents of the formulation, to hydroxyzine or to any piperazine derivatives. Hepatically impaired patients: Patients with chronic liver diseases (hepatocellular, cholestatic, and biliary cirrhosis) given 10 or 20 mg of cetirizine as a single dose had a 50 % increase in half-life along with a 40 % decrease in clearance compared to healthy subjects. Galpharm antihistamine tablets provide relief from the symptoms of hay fever and other airborne allergies. Galpharm Hay fever and Allergy Relief tablets can also be taken for skin allergies such as rash, itching, and urticaria (hives). The active ingredient in Galpharm antihistamine is Cetirizine, which is known as a non-drowsy antihistamine. It's much less likely to make you feel sleepy than some other antihistamines. Patients on hemodialysis (creatinine clearance less than 7 ml/min) given a single oral 10 mg dose of cetirizine had a 3-fold increase in half-life and a 70 % decrease in clearance compared to normals. At therapeutic doses, no clinically significant interactions have been demonstrated with alcohol (for a blood alcohol level of 0.5g/L). Nevertheless, precaution is recommended if alcohol is taken concomitantly.The distribution of pharmacokinetic parameters such as peak plasma concentration (Cmax) and area under curve (AUC), is unimodal in human volunteers. The extent of absorption of cetirizine is not reduced with food, although the rate of absorption is decreased. The extent of bioavailability is similar when cetirizine is given as solutions, capsules or tablets.

Galpharm Cetirizine Hayfever and Allergy Relief Tablets

Cetirizine was poorly cleared by haemodialysis. Dosing adjustment is necessary in patients with moderate or severe renal impairment (see section 4.2). Clinical studies have shown that cetirizine at the recommended dosage has minor undesirable effects on the CNS, including somnolence, fatigue, dizziness and headache. In some cases, paradoxical CNS stimulation has been reported. In addition to its anti-H1 effect, cetirizine was shown to display anti-allergic activities: at a dose of 10 mg once or twice daily, it inhibits the late phase recruitment of eosinophils, in the skin and conjunctiva of atopic subjects submitted to allergen challenge. Do not use Galpharm Cetirizine tablets after the expiry date shown and please read the enclosed leaflet before use. Objective measurements of driving ability, sleep latency and assembly line performance have not demonstrated any clinically relevant effects at the recommended dose of 10mg.

Giving you relief for up to 24 hours, Galpharm Hay fever and Allergy Relief tablets help to soothe common hay fever symptoms: such as itchy or watery eyes, sneezing and a runny nose. These long-lasting hay fever tablets also stop symptoms from other allergies e.g. pet, house dust mite and mould spore allergies. What is an allergy? Although statistically more common than under placebo, somnolence was mild to moderate in the majority of cases. Objective tests as demonstrated by other studies have demonstrated that usual daily activities are unaffected at the recommended daily dose in healthy young volunteers. In addition to the adverse reactions reported during clinical studies and listed above, the following undesirable effects have been reported in post-marketing experience.

Galpharm Hay Fever and Allergy Relief 14 Tablets | medino

Double blind controlled clinical trials comparing cetirizine to placebo or other antihistamines at the recommended dosage (10 mg daily for cetirizine), of which quantified safety data are available, included more than 3200 subjects exposed to cetirizine. The apparent volume of distribution is 0.50 l/kg. Plasma protein binding of cetirizine is 93 ± 0.3%. hydrochloride, Chlorphenamine, Clarityn, Galpharm, Haylief, Loratadine, Murine, Nasaleze, Numark, Opticrom, Optrex, Otrivine, Pirinase, Piriteze, pollenase and Sterimar.The steady – state peak plasma concentrations is approximately 300 ng/ml and is achieved within 1.0 ± 0.5 h. No accumulation is observed for cetirizine following daily doses of 10 mg for 10 days. Very common (>1/10); common (>1/100 to <1/10); uncommon (>1/1,000 to 1/100); rare (> 1/10,000 to 1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data)

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