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GEMSPARKLES Pika PikaChu Ring For Womens 0.25Ct Round Cut Clear CZ Diamond In 14K Two-Tone Gold Plated 925 Silver

£34.995£69.99Clearance
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A Pokémon lover can now express himself with a wide variety of Pokémon wedding rings. From silver, classic gold, tungsten, silicone, to white gold, the choices are almost endless online. Are There Women’s Pokémon Wedding Rings Bands? Detailed instructions on how to make full use of PIKAChU’s range of functionalities, as well as the script used to implement the ketoreduction reaction, can be found in the online documentation. Validation

Probst D, Reymond JL (2018) SmilesDrawer: parsing and drawing SMILES-encoded molecular structures using client-side javascript. J Chem Inf Model 58(1):1–7. https://doi.org/10.1021/acs.jcim.7b00425 Blin K, Shaw S, Kloosterman AM, Charlop-Powers Z, Van Wezel GP, Medema MH, Weber T (2021) AntiSMASH 6.0: improving cluster detection and comparison capabilities. Nucleic Acids Res 49(W1):W29–W35. https://doi.org/10.1093/nar/gkab335 Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE (2021) PubChem in 2021: New data content and improved web interfaces. Nucleic Acids Res 49(D1):D1388–D1395. https://doi.org/10.1093/nar/gkaa971 The ring, which is sold on U-Treasure (who make a lot of Pokémon jewellery), features a male and female Pikachu sitting either side of a 1-carat diamond, although you can't choose to have the Pikachus be the same gender, so that's a little limiting. I'll leave it at this this: this isn't about of gay Pokémon fans, it's about the market that exists to actually buy this product. How many LGBTQ+ Pokémon fans you know isn't exactly relevant. I'm categorically not saying that "gay gamers in love is too niche an audience" for any products to exist at all. It's a bit unfair to turn my argument that into that. This is a niche product by its price point, by the operating region of the company that makes it and by its potential audience. That's all.Kamada T, Kawai S (1989) An algorithm for drawing general undirected graphs. Inf Process Lett 31(1):7–15. https://doi.org/10.1016/0020-0190(89)90102-6 To assess PIKAChU’s drawing accuracy, we included a MOL file writer into PIKAChU, which stores PIKAChU-computed atom coordinates and connectivities as a MOL file. We generated such MOL files for the entire NP Atlas database and the 100,000 smallest molecules from the ChEMBL database, read the resulting MOL files with RDKit’s rdMolFiles module (v2020.09.1.0), stored the resulting molecules as SMILES strings, and using RDKit canonicalized both the original input SMILES and the SMILES produced from the PIKAChU-generated MOL files setting the ‘isomericSmiles’ flag to ‘True’. If the SMILES were identical, a PIKAChU-generated drawing was considered ‘correct’. Speed assessment Prior to visualisation, aromatic systems within a structure are kekulised so that aromatic systems can be represented by alternating single and double bonds. PIKAChU kekulises aromatic systems using a Python implementation [ 23] of Edmonds’ Blossom Algorithm for maximum matching [ 5]. Next, atoms are positioned using PIKAChU’s drawing software. PIKAChU’s python-based drawing algorithm was adapted and improved from SmilesDrawer [ 14], an open-source JavaScript library for molecular visualisation. While written in different programming languages, the algorithms underlying the drawing software of PIKAChU and SmilesDrawer are largely identical. We will briefly recap this algorithm below; more detailed descriptions of the algorithm’s elements can be found in the SmilesDrawer paper [ 14].

Substructures can be easily visualised through a range of functions in PIKAChU’s ‘general’ 'library. Fingerprinting An exception is made for nitrogens of valency 5, which are not chemically possible due to insufficient bonding orbitals but can sometimes be encountered in SMILES strings, especially in those describing compounds containing nitro groups. If such a valency 5 nitrogen is attached to at least one oxygen through a double bond, this double bond is interpreted as a single bond instead, the oxygen’s charge is set to − 1 and the nitrogen’s charge is set to 1, such that the nitrogen’s valency becomes 4 and bonding laws are obeyed. If a SMILES string yields a structure object that is chemically incorrect due to too many or too few bonds being attached to an atom or valence shells not being filled appropriately in the case of organic atoms, PIKAChU gives a StructureError, informing the user that the parsed structure is chemically incorrect and gives a rough indication of why. Two examples of such StructureError messages are ‘ Error parsing "F/C(\Cl)= C(F)/Cl": Conflicting double bond stereochemistry’ and ‘ Error parsing "CN(= O)= O": Basic bonding laws have been violated’. Visualisation and kekulisationTo measure PIKAChU’s drawing readability, atom coordinates were computed with PIKAChU and RDKit’s rdCoordGen module (v2020.09.1.0) for the 32,552 molecules in the NPAtlas database (v2021_08) and the 100,000 smallest molecules from the ChEMBL database (release 30). Next, all drawings were assessed for clashes. A clash was defined as two non-neighbouring atoms sitting at less than half an average bond length distance from each other in Euclidean space. Total number of clashes, number of structures containing clashes, and the number of structures that gave drawing errors were recorded. We demonstrated the implementation of reactions using PIKAChU by characterising and visualising a polyketide ketoreduction reaction. We built the ketoreduction reaction by first defining a reaction target as described above, in this case a β-keto bond, and detecting its position in a polyketide chain. Next, we wrote a function that reduces the double carbonyl bond to a single bond, which identifies and removes the π-electrons in the double bond, sets the bond type to single, adjusts the hybridisation of the atoms involved and finally updates the structure object through PIKAChU’s refresh functions. To finalize the reaction, two hydrogen atoms were added to the carbon and oxygen atoms of the former carbonyl bond using PIKAChU’s add_atom function. Finally, to visualise the reaction, we highlighted the atoms and bonds of the newly formed hydroxyl group in red and drew the molecule. They also offer a very unique couples wedding band set that features gold plated Pokéballs all around the ring meeting one master ball in the middle.

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