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Izquierdo L, Helle F, François C, Castelain S, Duverlie G, Brochot E. Simeprevir for the treatment of hepatitis C virus infection. Pharmgenomics Pers Med. 2014;7:241–9. Počas liečby sa môže objaviť vertigo, únava amalátnosť ako častý nežiaduci účinok (≥ 1/100 až < 1/10), preto je potrebná opatrnosť pri vedení vozidiel aobsluhe strojov.
mg/kg až do maximálnej dávky 60-80 ml/deň. Liečba je dlhodobá, kontinuálna, s pravidelným sledovaním zdravotného stavu pacienta a prehodnocovaním pokračovania v liečbe. Odporúčaná denná dávka sa môže zvýšiť, najmä v závažných prípadoch. Acyclovir is very effective in suppressing recurrent genital herpes and is clearly superior to isoprinosine which is not clinically useful in the dosage studied. PMCID: PMC2545279. Dostupné online [cit. 2021-04-02]. ISSN 0267-0623. DOI 10.1136/bmj.296.6622.646-b. PMID 2450620. Vírusové ochorenia s dlhším vývojom: v liečbe treba pokračovať ešte 1-2 týždne po ústupe symptómov, prípadne dlhšie, podľa rozhodnutia lekára. It īpaši pastāstiet savam ārstam, ja Jūs lietojat tālāk uzskaitītās zāles, kuras var reaģēt ar Isoprinosine tabletēm:
Dosing
TSANG, K. Y.; PAN, J. F.; SWANGER, D. L. In vitro restoration of immune responses in aging humans by isoprinosine. International Journal of Immunopharmacology. 1985, roč. 7, čís. 2, s. 199–206. PMID 2409037. Dostupné online [cit. 2021-03-27]. ISSN 0192-0561. DOI 10.1016/0192-0561(85)90027-x. PMID 2409037. RUMEL AHMED, S; NEWMAN, Amy S; O'DALY, James. Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: A clinical trial supporting anti-viral indications. International Immunopharmacology. 2017-01, roč. 42, s. 108–114. Dostupné online [cit. 2021-03-10]. ISSN 1567-5769. DOI 10.1016/j.intimp.2016.11.023.
Falzarano D, De Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, et al. Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques. Nat Med. 2013;19(10):1313–7. Favipiravir is a promising antiviral drug which targets the viral RNA-dependent RNA polymerase [ 100]. The drug gets converted to its active form by host enzymes and has exhibited considerable activity in influenza [ 100]. In a small clinical trial of COVID-19 patients, when compared to another potential drug arbidol, it showed a faster clinical recovery rate at day seven and more effectively reduced incidence of fever and cough [ 101]. In an open labelled trial of 70 patients in China, favipiravir had better viral clearance and improved lung imaging when compared to lopinavir/ritonavir [ 102]. The dosing used in the study was 1600 mg twice daily on the first day and 600 mg twice daily on day 2 to day 14. Side effects include raised serum uric acid levels, psychiatric symptoms and gastrointestinal disturbances [ 101]. Nucleoside analogues Liek obsahuje sodík (10 ml obsahuje viac ako 1 mmol (>24 mg) sodíka), čo je potrebné vziať do úvahy upacientov na diéte skontrolovaným obsahom sodíka.Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Treatment of SARS with human interferons. Lancet. 2003;362(9380):293–4. Chen C, Huang J, Cheng Z, Wu J, Chen S, Zhang Y, et al. Favipiravir versus Arbidol for COVID-19: a randomized clinical trial. medRxiv. 2020;2020.03.17.20037432.