200X Phone Microscope Lens with LED Light Portable Digital Microscope for Kids Handheld Microscope Dermatoscope Skin Diagnosis Hair Analyzer Compatible with iPhone and Android Mobile Phone(Black)

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Gopinath, S. C. B., Tang, T.-H., Chen, Y., Citartan, M. & Lakshmipriya, T. Bacterial detection: From microscope to smartphone. Biosens. Bioelectron. 60, 332–342 (2014). Chemical dyes, fluorescence, and confocal imaging are often employed to study beta-cell intracellular activities such as calcium influx, mitochondrial potential changes, zinc release kinetics, ROS production, and many others ( 32– 35). In this study, we used Fluo-4 and Rhodamin-123 to monitor cellular calcium influx and mitochondrial potentials, respectively. Like its predecessors, the iMicro Q3 is compatible with virtually any smartphone equipped with a camera, attaching seamlessly through a reusable nano-suction pad. This compatibility ensures that the iMicro Q3 can be used with a range of devices, making it a versatile tool for microscopic observation.

Fluorescence microscopy produces visually attractive images that can greatly enhance the contrast of specific features of the specimen being viewed. This microscopic imaging modality has historically involved costly and cumbersome mercury arc lamps or lasers. However, in recent years, comparatively inexpensive and compact laser-emitting diode (LED) technology is replacing mercury arc lamps and lasers in the microscopy industry. Advantages include lower cost, greater longevity, and maintenance free operation. Because LEDs have been engineered to emit light of virtually any wavelength on the visible light spectrum, and can be filtered if needed, the microscopy community is widely adopting use of LEDs as an excitation light source for fluorescence microscopy. Data were expressed as mean ± SD. For fluorescence intensity measurement and GSIS, all experiments were conducted under each stimulation protocol (n = 5, biological replicates, * p<0.05, ** p<0.01, *** p<0.001). Data were analyzed using Python 3.9.5, and plots were generated using Prism 9 (GraphPad, San Diego, California, USA). Result and discussion Imaging resolution validation of optical system Xu, X. et al. Advances in smartphone-based point-of-care diagnostics. Proc. IEEE 103, 236–247 (2015). Li, J.-F., Li, C.-Y. & Aroca, R. F. Plasmon-enhanced fluorescence spectroscopy. Chem. Soc. Rev. 46, 3962–3979 (2017). By connecting this USB microscope to the compatible PC or phone via the USB connector, it allows you to see micro-object images through the screen and screenshots or screen record the video. It’s compatible with Windows, Mac OS, and Linux devices and Android smartphones with the OTG function. It is, however, not compatible with iPhone or iPad. Additionally, this microscope also features 8 built-in LEDs with adjustable brightness. It also comes with a stable alloy stand, an OTG adapter, a ruler, a driver, and a carrying bag. This microscope’s design is user-friendly, portable, and lightweight, easy to carry around with you anywhere. 5. Carson MicroFlip 100x-250x LEDZhang, S., Dong, Y., Fu, H., Huang, S.-L. & Zhang, L. A spectral reconstruction algorithm of miniature spectrometer based on sparse optimization and dictionary learning. Sensors 18, 644 (2018). There has recently been interest concerning the use of smartphones as platforms to realize low-cost and portable scientific instruments for applications that include mobile chemical analysis and point-of-care medical diagnostics 1. Some notable developments have included microscopes for medical sample identification 2, intensity fluorimeters for measuring water pH 3, 4 and grating spectrometers for biological assay examination 5 and food testing 6, 7. In all cases, the scientific functionality is built into a module into which the smartphone is placed, and the design goal is to make the platform as small as possible.

Eye safety with LED components. Cree LED https://assets.cree-led.com/a/da/x/XLamp-Eye-Safety.pdf (2022).Human islet transplant is a promising cell-based therapy for Type I diabetes ( 2), in which isolated islet mass and function are key factors influencing islet transplant outcomes ( 3, 4). Conventionally, static glucose-stimulated insulin secretion (GSIS) assay is used to determine human islet functionality. Macro islet perifusion apparatus has also been recently applied to study insulin secretion kinetics of isolated human islets due to its advantages compared to GSIS, which can measure dynamic hormone secretion. GSIS only measures” bulk” insulin secretion over stimulation time and often “ignores” dynamic nature of insulin secretion such as phase, duration, and oscillation ( 5). Although those macro islet perifusion systems are widely utilized, they have many limitations including expensive system setup, significant reagent consumption, high difficulty to operate, and low throughputs, as well as single parameter assay ( 6– 8). Wang, Z. et al. Single-shot on-chip spectral sensors based on photonic crystal slabs. Nat. Commun. 10, 1020 (2019). Hughes, A. N. & Appel, B. Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nat. Commun. 10, 4125–4215 (2019).