AriZona x Marvel Super LXR Hero Hydration - Acai Blueberry - 16oz (Pack of 12) – Low Sugar Sports Drink, Perfect for Athletes, Vitamins and Natural Flavors - Thirst Quencher

Product Information

Unleash the beast and hydrate your way to ultimate power with Super LXR Hero Hydration: Citrus Lemon Lime flavour!

Tontonoz, P. & Mangelsdorf, D. J. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17, 985–993 (2003).Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253–1267 (2006). Kato, H., Sakaki, K. & Mihara, K. Ubiquitin–proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J. Cell Sci. 119, 2342–2353 (2006). Ratni, H. et al. Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator. Bioorg. Med. Chem. Lett. 19, 1654–1657 (2009). Chu, K., Miyazaki, M., Man, W. C. & Ntambi, J. M. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26, 6786–6798 (2006).

Bodzioch, M. et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22, 347–351 (1999). Ito, A. et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. eLife 4, e08009 (2015). Carlson, C. M., Frandsen, J. L., Kirchhof, N., McIvor, R. S. & Largaespada, D. A. Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc. Natl Acad. Sci. USA 102, 17059–17064 (2005).Endo-Umeda K, Makishima M. Endo-Umeda K, et al. Int J Mol Sci. 2019 Oct 11;20(20):5045. doi: 10.3390/ijms20205045. Int J Mol Sci. 2019. PMID: 31614590 Free PMC article. Review.

Good quality and I love the design. I like the jar idea rather than the bottles. Taking the Elite Multi and VitD.

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00836602 (2011).

Shimano, H. & Sato, R. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat. Rev. Endocrinol. 13, 710–730 (2017). Mak, P. A. et al. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J. Biol. Chem. 277, 31900–31908 (2002).Xin, Z. et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg. Med. Chem. Lett. 18, 4298–4302 (2008). The lipogenic activity of hepatic LXRα is a major limitation for the development of LXR agonists as therapeutics for atherosclerosis or Alzheimer disease. LXR activation increases lipogenesis through the control of sterol regulatory element-binding protein 1c and its target genes in liver.