Renova Menthol Sensitive Tissues Handkerchiefs (6 Packs of 9) - Extra Soft

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Fernandes E. S., Fernandes M. A., Keeble J. E. (2012). The functions of TRPA1 and TRPV1: Moving away from sensory nerves. Br. J. Pharmacol. 166 Corvalán N. A., Zygadlo J. A., García D. A. (2009). Stereo-selective activity of menthol on GABA(A) receptor. Chirality 21

Hanprasertpong T., Kor-anantakul O., Leetanaporn R., Suwanrath C., Suntharasaj T., Pruksanusak N., et al. (2015). Reducing pain and anxiety during second trimester genetic amniocentesis using aromatic therapy: A randomized trial. J. Med. Assoc. Thai. 98 TRPM8, also known as the cold and menthol receptor 1 (CMR1), is a protein encoded by the TRPM8 gene in humans. It is generally known that menthol is the agonist of TRPM8. The well-known chilling feeling that menthol causes when breathed, consumed, or applied to the skin is brought about by its capacity to chemically activate the cold-sensitive TRPM8 receptors in the skin. However, TRPM8 appears to perform far more functions than simply bringing coldness ( 6, 55, 79). As mentioned above, menthol-induced TRPM8 also plays an important physiological role in inflammation. Bromm B., Scharein E., Darsow U., Ring J. (1995). Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett. 187, 157–160. 10.1016/0304-3940(95)11362-z [ PubMed] [ CrossRef] [ Google Scholar] Chen S. R., Pan H. L. (2006). Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J. Neurophysiol. 95 Hemostasis and inflammation occur immediately after the tissue damage. Hemostasis is assisted by the formation of a fibrin hemostatic plug, preventing the bleeding. The prevention of infection is a process orchestrated by the inflammatory cells. Neutrophils and macrophages make phagocytosis of pathogens and tissue debris, as well as secret growth factors and cytokines, essential signaling molecules for triggering the proliferative phase [ 3, 4].Basso L., Aboushousha R., Fan C. Y., Iftinca M., Melo H., Flynn R., et al. (2019). TRPV1 promotes opioid analgesia during inflammation. Sci. Signal. 12:eaav0711. 10.1126/scisignal.aav0711 Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China In conclusion, it is seemingly that menthol administration in a great variety of experimental models and settings is associated with anti-inflammatory activity. This activity is characterized by a decrease in pro-inflammatory cytokines and related inflammatory markers, including those potentially linked to chronic inflammation, as well as pathway activation that is linked to the regulation of inflammatory enzymes and proteins. Furthermore, menthol administration in pathological inflammatory contexts appears to have favorable outcomes on histopathological characteristics of lesions and wider biological effects. As menthol is considered a safe agent for humans, given the widespread use and medical indications for menthol-containing products at present, the therapeutic potential of menthol as an anti-inflammatory can justifiably be considered on the basis of this review. Andersen H. H., Melholt C., Hilborg S. D., Jerwiarz A., Randers A., Simoni A., et al. (2017). Antipruritic effect of cold-induced and transient receptor potential-agonist-induced counter-irritation on histaminergic itch in humans. Acta Derm. Venereol. 97

Gillis D. J., Vellante A., Gallo J. A., D’Amico A. P. (2020). Influence of menthol on recovery from exercise-induced muscle damage. J. Strength Cond. Res. 34 Menthol has demonstrated anti-inflammatory effects within the gastric mucosa in an experimental model of ethanol-induced gastric ulcers ( 37). Ethanol-induced gastric ulcers are characterized by marked inflammatory responses following the generation of reactive oxygen species and a vigorous immune reaction ( 48). The study found that menthol administration led to an increase in anti-inflammatory interleukin (IL)-10 expression, while there was a reduction in pro-inflammatory markers, including IL-6 and tumor necrosis factor-α (TNF-α). The changes in these inflammatory markers were all statistically significant compared with baseline levels (P<0.001). This study investigated the antioxidant, anti-apoptotic, and anti-inflammatory effects of menthol, providing the potential to differentiate these effects within a model whereby all three factors contribute to ulceration and associated symptoms ( 37). Importantly, menthol administration led to a reduction in markers of antioxidant activity and a reduction in the neutrophilic immune response in the gastric mucosa, which collectively suggests a gastroprotective effect. As a simple monoterpene with remarkable biological properties, menthol possesses well-known cooling properties and a residual minty scent from the oil remnants. It is also known to exhibit biological activity in vitro and in vivo, including anti-inflammatory, antibacterial, analgesic, antipruritic, anticancer, and antifungal effects.Methods: Using the pharmacopeias and electronic databases, including Web of Science, PubMed, and CNKI, this study analyzed the relevant research articles and review articles from 2002 to 2022 and concluded those results and conjectures to finish this article.

Glyn-Jones S., Palmer A. J., Agricola R., Price A. J., Vincent T. L., Weinans H., et al. (2015). Osteoarthritis. Lancet 386Dierkes P. W., Hochstrate P., Schlue W. R. (1997). Voltage-dependent Ca2+ influx into identified leech neurones. Brain Res. 746 In addition, studies have shown that TRPA1, which is involved in the formation of harmful signals, significantly attenuates its association with μ-opioid receptors in the DRG, spinal cord and brain areas under the mediation by calcium-activated calmodulin in formalin-induced inflammatory pain and CCI-induced neuropathic pain in mice ( Cortés-Montero et al., 2020). Low cold sensitivity at high concentration (10% and 40%); cold allergy at low concentrations (0.01−1%) Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Common causes of neuropathic pain include cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system, for example, painful diabetic neuropathy, postherpetic neuralgia, or surgery ( Boyd et al., 2019). The first reported use of menthol in neuropathic pain dates to 1870, when menthol oil was successfully used to treat neuropathic facial pain.

Cliff M. A., Green B. G. (1994). Sensory irritation and coolness produced by menthol: Evidence for selective desensitization of irritation. Physiol. Behav. 56Bautista D. M., Jordt S. E., Nikai T., Tsuruda P. R., Read A. J., Poblete J., et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124 Flühr K., Neddermeyer T. J., Lötsch J. (2009). Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds. Clin. J. Pain 25 Filippov I. B., Vladymyrova I. A., Kuliieva Ie M., Skryma R., Prevarskaia N., Shuba, et al. (2009). [Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol]. Fiziol Zh (1994) 55 type":"clinical-trial","attrs":{"text":"NCT03888807","term_id":"NCT03888807"}}NCT03888807, {"type":"clinical-trial","attrs":{"text":"NCT04351594","term_id":"NCT04351594"}}NCT04351594, {"type":"clinical-trial","attrs":{"text":"NCT01565070","term_id":"NCT01565070"}}NCT01565070