BEE VENOM CREAM - 30ml FAST RELIEF MUSCLE JOINT PAIN VERY EFFECTIVE

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Palm NW, Rosenstein RK, Medzhitov R. Allergic host defences. Nature. (2012) 484:465–72. doi: 10.1038/nature11047

Based on the available research, it’s safe to say that adverse reactions — ranging from mild to potentially fatal — are common when using bee venom. For this reason, you should exercise extreme caution when using these products or treatments. Rizk JG, Kalantar-Zadeh K, Mehra MR, Lavie CJ, Rizk Y, Forthal DN. Pharmaco-Immunomodulatory therapy in COVID-19. Drugs. (2020) 80:1267–92. doi: 10.1007/s40265-020-01367-z Sometimes our busy schedules don't let us squeeze in regular workouts. For a temporary body-toning solution in between workouts, massage Nip + Fab's been venom and shea butter infused Body Souffle all over your body to make your skin appear firmer and toned. Bee venom is cytotoxic at high doses, however, non-cytotoxic concentrations of BV range from 1 to 3 μg/ml, show significant therapeutic potential ( 60). Low doses, controlled concentrations, and diluted BVs trigger a range of anti-inflammatory responses ( 61, 62), and have been deployed for management of diabetes, rheumatoid arthritis (RA), heart disease, obesity, asthma, skin diseases, and central nervous system-associated diseases, such as Alzheimer's disease, Parkinson's disease, and sclerosis ( 61– 64). At low doses, BV can suppress inflammatory cytokines such as interleukin-6 (IL-6), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). A decrease in the signaling pathways responsible for the activation of inflammatory cytokines, such as nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinases (ERK1/2) and protein kinase Akt, and porphyromonas gingivalis lipopolysaccharide (PgLPS)-treated human keratinocytes has been associated with treatments involving BV ( 65).

Certain methods of bee-venom therapy, including acupuncture, can lead to side effects, such as pain, swelling, and redness. Stiffness and pain in the shoulder joint (frozen shoulder). Early research suggests that receiving dilute bee venom injections might improve pain and disability in people with frozen shoulder. But it doesn't seem to improve range of motion. Also, very dilute bee venom injects don't seem to be beneficial. Just add water and Rodial's bee venom-infused balm transforms into a milky cleanser that brightens and firms skin.

Hong J, Lu X, Deng Z, Xiao S, Yuan B, Yang K. How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane. Molecules. (2019) 24:1775. doi: 10.3390/molecules24091775 Zahirović A, Luzar J, Molek P, Kruljec N, Lunder M. Bee venom immunotherapy: current status and future directions. Clin Rev Allergy Immunol. (2020) 58:326–41. doi: 10.1007/s12016-019-08752-x

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ErŽen R, Košnik M, Šilar M, Korošec P. Basophil response and the induction of a tolerance in venom immunotherapy: along term sting challenge study. Allergy. (2012) 67:822–30. doi: 10.1111/j.1398-9995.2012.02817.x Thus, it’s unclear how effective bee-venom therapy is as an alternative medicine treatment, as well as whether it’s any more effective than traditional treatments for conditions like rheumatoid arthritis, chronic pain, or autoimmune diseases. Bee venom is made by bees. This is the poison that makes bee stings painful. Bee venom is sometimes used to make medicine. Don't confuse bee venom with bee pollen, honey, propolis, or royal jelly. Eltahir Saeed WS, Gasim Khalil EA. Immune response modifying effects of bee venom protein [Melittin]/Autoclaved L. donovani complex in CD1 Mice: the search for new vaccine adjuvants. J Vaccines Vaccin. (2017) 08:6–11. doi: 10.4172/2157-7560.1000372

Caramalho I, Melo A, Pedro E, Barbosa MMP, Victorino RMM, Pereira Santos MC, et al. Bee venom enhances the differentiation of human regulatory T cells. Allergy. (2015) 70:1340–5. doi: 10.1111/all.12691 Bee venom is a natural product that has risen in popularity due to its variety of potential health benefits. Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. (2020) 117:9490–6. doi: 10.1073/pnas.2007408117 Chen J, Guan S-M, Sun W, Fu H. Melittin, the major pain-producing substance of bee venom. Neurosci Bull. (2016) 32:265–72. doi: 10.1007/s12264-016-0024-yGu H, Kim W-H, An H, Kim J, Gwon M, Han SM, et al. Therapeutic effects of bee venom on experimental atopic dermatitis. Mol Med Rep. (2018) 18:3711–8. doi: 10.3892/mmr.2018.9398 Hermann K, Ring J. The renin angiotensin system and hymenoptera venom anaphylaxis. Clin Exp Allergy. (1993) 23:762–9. doi: 10.1111/j.1365-2222.1993.tb00364.x Dawood AA. Mutated COVID-19 may foretell a great risk for mankind in the future. New Microbes New Infect. (2020) 35:100673. doi: 10.1016/j.nmni.2020.100673

The development of adjuvant therapies (using APi M and PLA2) to use against SARS-CoV-2 infections offers a unique approach to viral therapy. Bee venom vaccine development using DCs using APi M and bvPLA2 offers a new opportunity for complementary medicine interventions against SARS-CoV-2 infections. Studies to examine cellular signaling between BV proteins, Janus Kinase (JAK) and activator of transcription (JAK-STAT) would help strengthen its adoption in complementary medicine against SARS-CoV-2. Inhibitors of JAK are associated with improved prognosis in COVID-19 patients ( 72, 129) but studies are needed to elucidate the cellular mechanisms. Synergistic activity through combinations in alternative and complementary medicine would help combat side effects associated with current monotherapies for the management of SARS-CoV-2 infections. SARS-CoV-2 is a novel virus and novel therapies may be needed to support management over time and may be of value in supporting the immune response in patients suffering from so called long-COVID. Conclusion Straight from the hive, Miss Spa's gel sheet mask combines bee venom and 3D lifting technology to fight signs of aging like visible wrinkles, fine lines, and firmness, to make your complexion look instantly contoured. Sun D. Remdesivir for treatment of COVID-19: combination of pulmonary and IV administration may offer aditional benefit. AAPS J. (2020) 22:77. doi: 10.1208/s12248-020-00459-8 Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. J Microbiol Immunol Infect. (2020) 2020:5. doi: 10.1016/j.jmii.2020.03.022 Doo KH, Lee JH, Cho SY, et al. A Prospective Open-Label Study of Combined Treatment for Idiopathic Parkinson's Disease Using Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment. J Altern Complement Med. 2015;21(10):598-603. View abstract.

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Jung GB, Huh J-E, Lee H-J, Kim D, Lee G-J, Park H-K, et al. Anti-cancer effect of bee venom on human MDA-MB-231 breast cancer cells using Raman spectroscopy. Biomed Opt Express. (2018) 9:5703 doi: 10.1364/BOE.9.005703 Aqua (Water), Butylene Glycol, Hydrogenated Polydecene, Glycerin, Caprylic/Capric Triglyceride, Portulaca Oleracea Extract, Cetearyl Alcohol, Rosa Centifolia (Rose) Flower Extract, Polysorbate 60, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, PVM/MA Copolymer, Glyceryl Stearate, PEG-100 Stearate, Sorbitan Stearate, Dimethicone, 1,2-Hexanediol, Caprylyl Glycol, Citrus Grandis (Grapefruit) Seed Extract, Carbomer, Triethanolamine, Stearyl Glycyrrhetinate, Dipotassium Glycyrrhizate, Disodium EDTA, BHT, Mel (Honey), Lecithin, Ceramide 3, Tocopherol (Vitamin E), Hamamelis Virginiana (Witch Hazel) Extract, Chamaecyparis Obtusa (Japanese Cypress) Water, Bee Venom, Phenoxyethanol, Parfum (Fragrance).