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Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. More permanent lip augmentation options such as implants or fat transfer are more difficult to reverse or correct. Side Effects and Risks ResultsThe initial search for filler-related nodules or granulomas yielded 2,954 articles and 28 were included in the final analysis containing 66 individual cases of lip nodules. All but one patient was female. The mean age was 50 years. Nodules presented on average 35.2 months or 2.9 years after initial treatment. Thirty-seven nodules underwent histological analysis, the majority of which identified the presence of a foreign-body granuloma. Silicone was the most reported filler used followed by hyaluronic acid. Most cases resolved following multiple treatments including oral antibiotics or steroids followed by surgical excision. Following the procedure, you may experience some swelling and bruising for up to two weeks. You should follow some simple instructions and precautions to speed up recovery and avoid any complications: Preparation involves marking the treatment area and applying a topical numbing agent such as lidocaine. Some fillers contain lidocaine premixed in the vial.
Fat injections last years and are considered semipermanent, while surgically inserted synthetic implants made of silicone are truly permanent. Can lip fillers be reversed? Lee JM, Kim YJ. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg. 2015;42(2):232-239. doi:10.5999/aps.2015.42.2.232Collagen is a natural compound that can be used as a lip filler. However, the collagen used in soft tissue fillers is extracted from animals, which poses a risk of allergic and inflammatory reactions. An allergy test is necessary before receiving collagen injections. A histological analysis of 37 cases was reported. Thirty-one (83.8%) of these confirmed a foreign-body granuloma. The other cases reported extensive or chronic inflammation, sarcoid-like reaction, and a pseudocystic, fibrous-structure-containing translucent, viscous material that stained positive for Alcian blue (a marker for HA). Many patients were initially treated with nonoperative methods such as NSAIDs, antibiotics, and systematic and/or intralesional steroids. Laser therapy has also been successfully used. Lastly, bacteria inoculated during the injection may form a biofilm. The biofilm surrounding the HA material creates a matrix that can inhibit natural hyaluronidases from degrading the HA. These biofilms can induce a minimal infection with little host response, making them asymptomatic for months or even years. Restylane-L for results similar to Restylane but with an additional numbing agent for added comfort during the injection process.
Lip implants are an in-office procedure. Your surgeon will first sterilize the area and use a local anesthetic to numb the lips. While lip implantation can be performed under general anesthesia, it isn’t required.Batniji RK, et al. (2002). Tissue response to expanded polytetrafluoroethylene and silicone implants in a rabbit model. These lip fillers can be safely dissolved using hyaluronidase injections which effectively breaks down the filler over a period of 24–48 hours. The length of time will vary depending on the quantity and depth of the filler. This is a fast-acting and safe procedure with minimal side effects. Silicone granulomas have been reported in other areas of the face such as the eyelids and cheek and the onset ranged from 5 months to 15 years, which is similar to that of our observed cases.
The downside of using a numbing cream is that it can cause some swelling, which can make it harder for the provider to gauge the results with precision, until the swelling goes down. Aftercare If there are no complications, the entire surgery takes roughly 30 minutes, and you can drive home afterward. Recovery There is no downtime following lip filler injections – you can follow your daily routine immediately, keeping in mind the aforementioned precautions. Lip fillers at home Antibiotics (quinolones) and NSAIDs: no effect, oral prednisone+hydroxychloroquine (400mg/d): nodules resolvedHA is considered the best option for nonsurgical lip augmentation. The simplicity of the procedure, relatively low cost and consistently good results make it an excellent choice. Goldman and Wollina reported granulomas after PMMA injection which was first treated by intralesional 1,064nm Nd:YAG laser in combination with suction using a blunt liposuction cannula either alone or combined with surgery. Lip augmentation with dermal fillers is rising in popularity. This systematic review analyzed reported cases of granulomas or nodules secondary to any dermal filler for lip augmentation. Of the 66 cases, 31 (47.0%) confirmed the presence of a delayed-onset foreign-body granuloma. Of note, not all nodules are considered granulomas. n=55) months. Most patients presented with swelling, asymmetry, or erythema of their lips. Twenty-six cases (38.2%) presented with multiple nodules, 19 (27.9%) reported single nodules, and 23 cases (33.8%) did not report on the number of nodules. Masses were frequently described as discrete, indurated, mobile, firm, and slowly growing. Brody, H. J. (2001), Complications of Expanded Polytetrafluoroethylene (e‐PTFE) Facial Implant. Dermatologic Surgery, 27: 792-794. doi:10.1046/j.1524-4725.2001.01014.x
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