Acer Aspire 3 Notebook Laptop (A317-33) 17.3" Windows 11 Home, Full HD (1920 x 1080) 16:9 IPS Display, Intel Pentium Silver N6000 Processor, 8GB DDR4 SDRAM, 2 56 GB PCI. e SSD

Product Information

In the illustration below you can see how the display performs from a uniformity perspective. In other words, the leakage of light from the light source. Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331:1565–1570. https://doi.org/10.1126/science.1203486

Shultz LD, Schweitzer PA, Christianson SW et al. (1995) Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 154:180–191A multicenter, randomized, open‐label study to compare the efficacy and safety of tislelizumab (BGB A317, anti–PD1 antibody) combined with paclitaxel plus carboplatin or nab paclitaxel plus carboplatin versus paclitaxel plus carboplatin alone as first‐line treatment for untreated advanced squamous non‐small cell lung cancer

Acer Aspire 3 (A317-33) has a Full HD IPS panel, made by LG with a model number LP173WF5-SPZ1 (LGD0671). Its diagonal is 17.3″ (43.94 cm), and the resolution 1920 х 1080 pixels. The screen ratio is 16:9, and we are looking at a pixel density of – 127 ppi, and a pitch of 0.2 х 0.2 mm. The screen turns into Retina when viewed at distance equal to or greater than 69cm (27″) (from this distance one’s eye stops differentiating the separate pixels, and it is normal for looking at a laptop).The measured maximum brightness of 299 nits in the middle of the screen and 286 nits as an average for the whole area, with a maximum deviation of 10%. The Correlated Color Temperature on a white screen is 6470K – almost matching the optimal for the sRGB standard of 6500K. Mouse blood samples were collected from retro-orbital sinus at indicated time points. The concentration of BGB-A317 or BGB-A317/IgG4 S228P in serum was determined by ELISA. Briefly, serum samples were added to PD-1/His protein (2 µg/ml)-coated ELISA plates (Nunc), followed by the capture with anti-huIgG-HRP (Sigma) and color development. OD values at 450 nm were detected by a Microplate Reader (SpectraMax ® Paradigm ®). The results were analyzed with SoftMax Pro software (Molecular Devices). IHC and immunofluoresence staining Bellmunt J, de Wit R, Vaughn DJ et al (2017) Pembrolizumab as second-line therapy for advanced urothelial carcinoma. N Engl J Med 376:1015–1026. https://doi.org/10.1056/NEJMoa1613683

Simulations were performed to compare tislelizumab exposure with the 200mg q3w flat dose regimen and a hypothetical 3mg/kg q3w WT‐based dose regimen to understand the effect of WT. The dose of 3mg/kg was chosen for this comparison as it corresponds to a 200mg dose for a 65kg patient, which is the median WT in the analysis dataset (Table S2). The extent and variability of exposure from these dose regimens were simulated from post hoc estimates from 2596 cancer patients included in the PopPK analysis.A single‐arm, multicenter, phase II study of tislelizumab (BGB‐A317) as monotherapy in relapsed or refractory classical Hodgkin lymphoma