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Girls Frozen Socks - Pack of 2

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No significant difference in Neuropathic Pain Symptom Inventory scores for symptoms in hands ( p> .15) or feet ( p> .30); no significant difference in quantitative sensory testing results ( p> .15); and pain severity using the Brief Pain Inventory was increased for all measures across time

Frozen Sock - Etsy UK

Improved preservation of sensory nerve action potential amplitude in the sural nerve. Did not achieve statistical significance ( p = .16) Marks D. H., Qureshi A., & Friedman A. (2018). Evaluation of prevention interventions for taxane-induced dermatologic adverse events: A systematic review. JAMA Dermatology, 154( 12), 1465–1472. 10.1001/jamadermatol.2018.3465 [ PubMed] [ CrossRef] [ Google Scholar] Mols F., Beijers T., Vreugdenhil G., & van de Poll-Franse L. (2014). Chemotherapy-induced peripheral neuropathy and its association with quality of life: A systematic review. Supportive Care in Cancer, 22( 8), 2261–2269. 10.1007/s00520-014-2255-7 [ PubMed] [ CrossRef] [ Google Scholar] Evaluate efficacy of compression with surgical gloves to prevent nanoparticle albumin-bound paclitaxel-associated peripheral neuropathy Patient Neurotoxicity Questionnaire results: significantly lower grades of peripheral neuropathy in the intervention side ( p< .0001)Hanai A., Ishiguro H., Sozu T., Tsuda M., Yano I., Nakagawa T.,...Tsuboyama T. (2018). Effects of cryotherapy on objective and subjective symptoms of paclitaxel-induced neuropathy: Prospective self-controlled trial. Journal of the National Cancer Institute, 110( 2), 141–148. 10.1093/jnci/djx178 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar] One of the two studies that applied a relatively lesser amount of cooling as defined in this review achieved statistically significant benefits in the severity of peripheral neuropathy ( Tsuyuki et al., 2016). This prospective, self-controlled study included 42 breast cancer patients who received compression therapy with two surgical gloves sized one size too small worn on the dominant hand, which resulted in a decrease in fingertip temperature on the intervention side. Subjects received nab-paclitaxel every 3 weeks for four cycles. Outcomes were measured using the CTCAE and the PNQ and were recorded at baseline, before each treatment cycle, and 1 week after nab-paclitaxel was administered. CTCAE results demonstrated a decrease in the incidence of ≥ grade 2 peripheral neuropathy on the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2%. Patient Neuropathy Questionnaire results demonstrated significantly lower grades of peripheral neuropathy on the intervention side ( p< .0001).

Frozen Socks - Etsy UK

Small sample size with high dropout rate (29 down to 7) in part due to discomfort with intervention Tofthagen C., Overcash J., & Kip K. (2012). Falls in persons with chemotherapy-induced peripheral neuropathy. Supportive Care in Cancer, 20( 3), 583–589. 10.1007/s00520-011-1127-7 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Tsuyuki S., Senda N., Kanng Y., Yamaguchi A., Yoshibayashi H., Kikawa Y.,...Inamoto T. (2016). Evaluation of the effect of compression therapy using surgical gloves on nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A phase II multicenter study by the Kamigata Breast Cancer Study Group. Breast Cancer Research in Treatment, 160( 1), 61–67. 10.1007/s10549-016-3977-7 [ PubMed] [ CrossRef] [ Google Scholar] Although clinical exams for neuropathy and total neuropathy scores were performed, comparisons between intervention and control side not included in evaluationTofthagen C. (2010). Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing, 14( 3), E22–E28. 10.1188/10.CJON.E22-E28 [ PubMed] [ CrossRef] [ Google Scholar] Measurements at baseline, 2 weeks post treatment completion, and at first, fifth, ninth, and final weekly paclitaxel treatments No statistically significant preservation of hand or foot cold sense, vibration perception, electrophysiological measurements

Frozen | BIG W Frozen | BIG W

Compound motor action potential amplitudes of motor nerves more preserved at 3 months post treatment. Did not achieve statistical significance. Extensor digitorum brevis compound motor action potential amplitudes more preserved on intervention side below fibula head ( p = .07) and above fibula head ( p = .10). Hershman D. L., Lacchetti C., & Loprinzi C. L. (2014). Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary. Journal of Oncology Practice, 10( 6), e421–e424. 10.1200/JOP.2014.001776 [ PubMed] [ CrossRef] [ Google Scholar] Komen M. M., Smorenburg C. H., van den Hurk C. J., & Nortier J. W. (2013). Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. Oncologist, 18( 7), 885–891. https://dx.doi.org/10.1634%2Ftheoncologist.2012-0332 [ PMC free article] [ PubMed] [ Google Scholar]Similar benefit after subsequent chemo cycles (odds ratio: 0.59; 95% CI = 0.46–0.76, p< .0001), although analysis of impact of preexisting peripheral neuropathy not performed in statistics for late peripheral neuropathy group

The Impact of Peripheral Cooling on Chemotherapy-Induced

Shah A., Hoffman E. M., Mauermann M. L., Loprinzi C. L., Windebank A. J., Klein C. J., & Staff N. P. (2018). Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. Journal of Neurology, Neurosurgery, and Psychiatry, 89( 6), 636–641. 10.1136/jnnp-2017-317215 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] de Lemos M. L., & Walisser S. (2005). Management of extravasation of oxaliplatin. Journal of Oncology Pharmacy Practice, 11( 4), 159–162. 10.1191/1078155205jp165oa [ PubMed] [ CrossRef] [ Google Scholar]Sundar R., Bandla A., Tan S. S., Liao L. D., Kumarakulasinghe N. B., Jeyasekharan A. D.,...Wilder-Smith E. P. (2016). Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study. Frontiers in Oncology, 6, 274 Symptoms assessed at baseline and before every cycle of paclitaxel administration during outpatient care Pérez Fidalgo J. A., García Fabregat L., Cervantes A., Margulies A., Vidall C., & Roila F. (2012). Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Annals of Oncology, 23( Suppl 7), vii167–vii173. 10.1093/annonc/mds294 [ PubMed] [ CrossRef] [ Google Scholar]

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