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Severe allergic reaction: If you have a severe allergic reaction to GABA or any of its components (ingredients), you shouldn’t take this medication. Without enough GABA reactivity, your excitatory neurotransmitters can take over, putting your neurons into a state of hyperexcitement. Though GABA plays an important role in sleep, there isn’t much in the way of direct clinical research on the effects of GABA supplementation on sleep duration or sleep quality, like there is with a supplement like melatonin . People with a history of schizophrenia or related mental health issues, or a family history of schizophrenia, should probably not take a GABA supplement. https://www.fda.gov/files/food/published/GRAS-Notice-000595--Gamma-Aminobutyric-Acid-%28GABA%29.pdf
Especially active people may also find that GABA helps with recovery and may increase exercise tolerance. Health Benefits An older study from 2012 found that taking 100 mg of GABA daily helped reduce stress due to mental tasks. Like many other studies related to GABA, the study was small and involved just 63 participants. Workout recovery and muscle building Blood pressure medications: GABA may lower your blood pressure. This may have additive effects with antihypertensives, such as Microzide (hydrochlorothiazide). GABA is most often used as an anti-anxiety remedy but has many other reported benefits. Supplementing with GABA can help with inflammation issues, which means it may provide relief for people with PMS or other conditions that come with chronic pain. At GABA Labs, we aren’t against alcohol and can understand its appeal and the role it has played in society for centuries. Humans are social beings, and alcohol can support connecting, relaxing, and bringing people together. However, we maintain that if over-used, alcohol is a dangerous substance.
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However, people who have medical conditions characterized by excess GABA levels probably should not take a GABA supplement. The prime example of this is schizophrenia—research published in 2010 suggests that people who have schizophrenia, even when it’s been stabilized by medication, have higher levels of GABA than healthy people ( 10 ). Kumar V, Vajawat B, Rao NP Frontal GABA in schizophrenia: A meta-analysis of H-MRS studies. World J Biol Psychiatry. (2021-Jan)
Hinton T, Jelinek HF, Viengkhou V, et al. Effect of GABA-fortified oolong tea on reducing stress in a university student cohort. Frontiers in Nutrition. 2019;6:27. doi: 10.3389%2Ffnut.2019.00027 GABA activators cause the release of GABA in the brain, which leads to feelings of relaxation and sociability—you’ll know the feeling if you’ve ever had a couple of pints or a large glass of wine. GABA enhancers boost the effects of the GABA released by your brain, while Bio-enhancers facilitate both the release and effect of GABA by aiding the uptake of activators and enhancers. Volpi R, Gerra G, Vourna S, Vescovi PP, Maestri D, Chiodera P, Coiro V Failure of the gamma-aminobutyric acid (GABA) derivative, baclofen, to stimulate growth hormone secretion in heroin addicts. Life Sci. (1992)
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The scientists have chosen to specifically target the gamma-aminobutyric acid (GABA) system in the brain, which is known for producing a calming effect. Yoto A, et al. (2012). Oral intake ofgamma-aminobutyric acid affects mood and activities of central nervous systemduring stressed condition induced by mental tasks. DOI: de Jonge JC, Vinkers CH, Hulshoff Pol HE, Marsman A. GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies. Front Psychiatry. 2017 Aug 11;8:118. doi: 10.3389/fpsyt.2017.00118.x
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