Devil's Claw Gel 98% Extra Strong, 100 ml, Made in Italy for Massage to Joints and Muscles, Natural Formula and Dermatologically Tested on Sensitive Skin - Dulàc Pharma

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Common medications may also negatively interact with devil’s claw, including prescription nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners and stomach acid reducers ( 31): Though devil’s claw has not been studied extensively in humans, preliminary evidence suggests that it may be an alternative treatment for inflammatory conditions. Summary Moussard C, Alber D, Toubin MM, et al. A drug used in traditional medicine, harpagophytum procumbens: no evidence for NSAID-like effect on whole blood eicosanoid production in human. Prostaglandins Leukot Essent Fatty Acids. 1992;46:283-6.. View abstract.

Chrubasik, S. Addendum to the ESCOP monograph on Harpagophytum procumbens. Phytomedicine. 2004;11(7-8):691-695. View abstract. Hagiwara H, Seki T, Ariga T. The effect of pre-germinated brown rice intake on blood glucose and PAI-1 levels in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 2004;68:444-7. View abstract. It is important to stay as active as possible and to keep up your daily activities. Resting for long periods can actually make the pain worse. NSAIDs: Devil’s claw may slow the absorption of popular NSAIDs, such as Motrin, Celebrex, Feldene and Voltaren.

Generally, their quality of life improved and 60% of patients either reduced or stopped some of their pain medication. Gallstones: Devil's claw might increase bile production. This could be a problem for people with gallstones. Avoid using devil's claw. The root of the Devil Claw herb tends to be dried out, powdered, and used in remedies. One of this root’s most potent active ingredients is Iridoid Glycosides - a group of compounds thought to be responsible for its beneficial effects. Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4. View abstract. Low levels of sodium in the body: Devil's claw might decrease levels of sodium in the body. This might worsen symptoms in people who already have low levels of sodium.

Betancor-Fernandez, A., Perez-Galvez, A., Sies, H., and Stahl, W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol 2003;55:981-986. View abstract.Clarkson, C., Campbell, W. E., and Smith, P. In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (devil's claw). Planta Med 2003;69:720-724. View abstract. Langmead L, Dawson C, Hawkins C, and et al. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther 2002;16:197-205. Gout is another common form of arthritis, characterized by painful swelling and redness in the joints, usually in the toes, ankles and knees ( 19). For other conditions, sufficient studies to determine effective doses are unavailable. In addition, devil’s claw has only been used for up to one year in studies. However, devil’s claw appears to be safe for most people in doses up to 2,610 mg per day ( 29). Chrubasik S, Sporer F, and Wink M. [Content of active substance in tea preparations from Harpagophytum procumbens]. Forsch Komplementarmed 1996;3:116-119.

Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999. Chrubasik, S., Conradt, C., and Roufogalis, B. D. Effectiveness of Harpagophytum extracts and clinical efficacy. Phytother.Res. 2004;18:187-189. View abstract. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56. View abstract. Inflammation is your body’s natural response to injury and infection. When you cut your finger, bang your knee or come down with the flu, your body responds by activating your immune system ( 6).Devil’s claw appears to be safe when taken in doses up to 2,610 mg daily, though long-term effects have not been investigated ( 29). Chrubasik S, Sporer F, Dillmann-Marschner R, et al. Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. Phytomedicine 2000;6:469-73. View abstract.

Fiebich BL, Heinrich M, Hiller KO, Kammerer N. Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001;8:28-30.. View abstract.Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.