Impryl - Conception - Fertility Supplement for Men and Women - Maximise Sperm and Egg Quality for Conception - 30 Tablets - Pregnancy Vitamins - Vegan

Product Information

Impryl is the first antioxidant dietary supplement based on a well defined mechanism of action: indirect antioxidant activity by means of the modulation of the enzyme CBS that regulates the synthesis of glutathione (GSH), the primary cellular antioxidant.

All the 3 main enzymes eliminating homocysteine to form methionine or cysteine are zinc-dependent and the OCM cannot work properly if any shortage of zinc is in place. Thus, it is very important for the effects of Impryl. DNA fragmentation is the ‘snipping up’ of DNA in the sperm head, which can contribute towards difficulties in conceiving and/or miscarriage. DNA fragmentation is often treated with strong anti-oxidants such as Vitamin C, Vitamin E, Selenium, CoQ10, Vitamin A and Carotenoids. However, we now know that although they might prevent DNA fragmentation, these strong anti-oxidants can then cause DNA de-condensation, which is the unravelling of the DNA in the sperm head, meaning that conception is not possible at all. Unlike Impryl, many other supplements contain these strong anti-oxidants. I wanted to post this because I felt devastated after the first analysis. Every single one of my husband’s parameters, including count, has improved drastically in % terms. The protocol and all protocol modifications are approved by the local METC at the Radboud University Medical Centre and by the national Central Committee on Research Involving Human Subjects with protocol ID NL61414.091.17.We aimed to recruit 1200 male participants as a part of an infertile couple, based on the following data and power calculation. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 1987;81:459–69. 10.1530/jrf.0.0810459

A methyl group is a single carbon atom bonded with three hydrogen atoms. The methionine pathway of One Carbon Metabolism (OCM) produces S-adenosylmethionine (SAMe), the universal activated methyl donor in the human body. Methyl groups can be dynamically transferred to and from biological macromolecules such as DNA, RNA and proteins in a process called methylation to influence structure and function. What is homocysteine (HCY)? Funding The study is supported by an unrestricted grant from Goodlife Pharma BV. This company has developed and marketed Impryl. The grant is unrestricted in means that the funder did not have any role in the design of the study, collection, analysis and/or interpretation of data. The investigators have full access to the data and have the right to publish these data separate and apart from any sponsor.Impryl’s unique balance of micronutrients prevents DNA fragmentation without causing DNA de-condensation. Glutathione (GSH) is the main antioxidant in the human body. It diffuses everywhere and continuously re-charges with antioxidant power all the other physiologic antioxidants. Important, GSH is not a dietary substance and is not provided by the diet neither can be assumed as a supplement. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM) using homocysteine/cysteine as the main substrate. The sponsor will report expedited the following SUSARs through the web portal ToetsingOnline to the METC:

Patients who are lost to follow-up during the treatment period are considered not to have achieved a pregnancy. I am not pregnant yet, but my tests showed no issues. I hope this gives someone hope and we will conceive soon. Time to pregnancy defined as (1) the time between randomisation and reaching ongoing pregnancy (confirmed by ultrasound) and (2) the time between start of fertility treatment during the study (EM, IUI and IVF/ICSI) and reaching ongoing pregnancy.

DNA fragmentation is the ‘snipping up’ of DNA in the sperm head, which can contribute towards difficulties in conceiving and/or miscarriage. DNA fragmentation is often treated with strong anti-oxidants such as Vitamin C, Vitamin E, Selenium, CoQ10, Vitamin A and Carotenoids. However, we now know that although they might prevent DNA fragmentation, these strong anti-oxidants can then cause DNA de-condensation, which is the unravelling of the DNA in the sperm head, meaning that conception is not possible at all. An elective hospital admission will not be considered as a SAE. The investigator will report all SAEs to the sponsor and METC without undue delay after obtaining knowledge of the events.