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Optrex Allergy 2% w/v Eye Drops, for the relief and treatment of seasonal and perennial allergic conjunctivitis, contains sodium cromoglicate Liposomal sprays, like Optrex TM ActiMist TM, contain soy lecithin, a phospholipid, which is encapsulated within microscopic spherical liposomal vesicles. Soy lecithin is an emulsifier, which due to its bipolar nature enables the water and oil layers of the eye to work together. How do liposomal sprays work? Around 40% of community pharmacies see at least one patient a day* who has a concern about their eyes and studies show that up to 30 per cent of the population over the age of 50 experience dry eye symptoms on a regular basis [5]
After applying the spray to the closed eyelid, blinking distributes liposomes evenly over the aqueous layer of the tear film Evidence of the mechanism of action
to ease the irritation and discomfort of evaporative dry eye. They provide instant relief and last for up to four hours [1], [4]
Research has shown that individuals without a visible lipid layer, or with a nonconfluent lipid layer, exhibit a four-fold higher rate of tear film evaporation [Despite this, a 2016 survey of pharmacists*, showed that two out of three respondents were unaware that there are different types of dry eye condition, which have different aetiology, and therefore required different management. The sprayed-on phospholipid liposomes reach the lid margins via the same effect and mix with the endogenous lipids to help repair the tear film lipid layer Optrex Bloodshot Eye Drops, for temporary relief of redness of the eye due to minor eye irritations, contains witch hazel and naphazoline hydrochloride
This article is intended to help pharmacists understand and convey the benefits of liposomal sprays to sufferers of dry eye, by considering their mode of action in relation to the stabilization of the tear film. What are liposomal sprays? Some PBS medications are restricted and require prior approval from Medicare before a doctor is able to prescribe them on the PBS. This prior approval to prescribe grants the doctor the Authority to prescribe the desired medicine and have it funded under the PBS. In evaporative dry eye, the meibomian gland (pictured inset) fails to secrete enough oil to maintain the lipid layer of the tear film Suitable For: Adults 16 years and over. For dry eyes due to disturbed lipid layer of the tear film. Prescriptions must be written on an Authority Prescription Form, and the approval number must be noted on the prescription. Pharmacists cannot dispense the item as a pharmaceutical benefit unless it has been approved by Medicare Australia (indicated by the presence of the approval number).
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Optrex Hayfever Relief 2% w/v Eye Drops, for the relief and treatment of the eye symptoms of Hayfever, contains sodium cromoglicate By recommending liposomal spray for the treatment of EDE, explaining how to use it and importantly, how it works when sprayed on closed eyes, pharmacists can help contribute to ensuring patients receive a treatment that is appropriate, acceptable and will help relieve the symptoms of dry eye. In 80 per cent of people with dry eye, the cause is deficiency or instability of the lipid layer of the tear film Three main layers make up the normal tear film. In 80% of people with dry eye, the cause is deficiency or instability of the lipid layer
Optrex Infected Eye Drops, for treatment of acute bacterial conjunctivitis, contains chloramphenicol contains: 10mg Lecithin, 8mg Sodium Chloride, 8mg Ethanol, 0.25mg Vitamin A Palmitate, 0.02mg Vitamin E, Purified water.Optrex Sore Eye Drops, for the relief of minor eye irritations caused by dusty or smoky atmospheres, driving or close work, contains witch hazel Authority to prescribe an Authority medicine is granted for specific indications and/or for certain patient circumstances. Authority may be obtained by telephone to Medicare Australia (known as "phone approval") or in writing from an authorised delegate of the Minister for Health. However, the mode of action and method of application of liposomal sprays are not always well understood, in particular, it can be complicated to explain how a liposomal spray reaches the surface of the eye after being applied to a closed eyelid. while another concludes that treatment with phospholipid liposomes shows statistically significant clinical advantages with better results in the lid parallel conjunctival fold (LIPCOF) test, tear film break-up time (BUT), Schirmer-I test, tear meniscus measurement, inflammation of the lid margins, and visual acuity, compared to conventional artificial tears treatment [1] This is similar to what happens naturally when lipids are secreted from the meibomian glands (see figure 3) on to the lid margins where they form a reservoir. Blinking puts pressure on the meibomian glands, resulting in a small amount of oil being expressed onto the lid margins, and the lipids that were part of the tear film mix once again with the lipid reservoir on the lid margin. During the opening of the lids, some of the lipids from this reservoir spread onto the tear film, forming a lipid layer [1]
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