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Kuby Immunology: 7th Edition: International Edition

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Proliferating T cells differentiate into armed effector T cells that do not require co-stimulation to act Transplants involve transferring cells, tissues or organs from a donor to a recipient. The most formidable barrier to transplants is the immune system’s recognition of the transplanted organs as foreign. Understanding the mechanisms and clinical features of rejection is important in determining a diagnosis, advising treatment and is critical for developing new strategies and drugs to manage transplants and limit the risk of rejection. An immunologist is a scientist and/or clinician who specialises in immunology. Many immunologists work in a laboratory focusing on research, either in academia or private industry (e.g. in the pharmaceutical industry). Other immunologists – “clinical immunologists” – are clinicians who focus on the diagnosis and management of diseases of the immune system, such as autoimmune diseases and allergies. Newly synthesized MHC class I molecules are retained in the endoplasmic reticulum until they bind peptide Homeostasis of lymphocyte populations is maintained by signals that lymphocytes are continually receiving through their antigen receptors

Mast cells, basophils, and activated eosinophils bind IgE antibody via the high-affinity Fcε receptorThe humoral immune response is initiated when B cells that bind antigen are signaled by helper T cells or by certain microbial antigens alone Binding of the T-cell receptor complex directs the release of effector molecules and focuses them on the target cell T-cell α-chain genes undergo successive rearrangements until positive selection or cell death intervenes Some peptides and lipids generated in the endocytic pathway can be bound by MHC class I-like molecules that are encoded outside the MHC

hematopoietic stem cell development, she accepted a position as associate dean for student research at Columbia Mucosa-associated lymphoid tissue is located in anatomically defined microcompartments throughout the gut

Contents

The variable chains of lymphocyte antigen receptors are associated with invariant accessory chains that carry out the signaling function of the receptor

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