BEE VENOM CREAM - 30ml FAST RELIEF MUSCLE JOINT PAIN VERY EFFECTIVE

Product Information

University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, China of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt

You agree to indemnify and hold Space NK (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party. Bee venom is POSSIBLY SAFE when given by live bee stings. Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks. Bee venom is a natural product that has risen in popularity due to its variety of potential health benefits. Mehra MR, Desai SS, Kuy SR, Henry TD, Patel AN. Cardiovascular disease, drug therapy, and mortality in COVID-19. N Engl J Med. (2020) 382:E102. doi: 10.1056/NEJMoa2007621 Heaven by Deborah Mitchell is a luxurious range of anti- ageing, skincare containing organic, natural and results driven ingredients, which have been developed for a radiant, flawless complexion and to help heal skin conditions, from blemishes to eczema.A 12-week study in 22 women demonstrated that applying a facial serum containing bee venom twice daily significantly reduced wrinkle depth and total wrinkle count, compared with the placebo ( 15). Bee venom is cytotoxic at high doses, however, non-cytotoxic concentrations of BV range from 1 to 3 μg/ml, show significant therapeutic potential ( 60). Low doses, controlled concentrations, and diluted BVs trigger a range of anti-inflammatory responses ( 61, 62), and have been deployed for management of diabetes, rheumatoid arthritis (RA), heart disease, obesity, asthma, skin diseases, and central nervous system-associated diseases, such as Alzheimer's disease, Parkinson's disease, and sclerosis ( 61– 64). At low doses, BV can suppress inflammatory cytokines such as interleukin-6 (IL-6), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). A decrease in the signaling pathways responsible for the activation of inflammatory cytokines, such as nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinases (ERK1/2) and protein kinase Akt, and porphyromonas gingivalis lipopolysaccharide (PgLPS)-treated human keratinocytes has been associated with treatments involving BV ( 65). Cho H-J, Jeong Y-J, Park K-K, Park Y-Y, Chung I-K, Lee K-G, et al. Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-κB-dependent mechanisms. J Ethnopharmacol. (2010) 127:662–8. doi: 10.1016/j.jep.2009.12.007 Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom

The development of adjuvant therapies (using APi M and PLA2) to use against SARS-CoV-2 infections offers a unique approach to viral therapy. Bee venom vaccine development using DCs using APi M and bvPLA2 offers a new opportunity for complementary medicine interventions against SARS-CoV-2 infections. Studies to examine cellular signaling between BV proteins, Janus Kinase (JAK) and activator of transcription (JAK-STAT) would help strengthen its adoption in complementary medicine against SARS-CoV-2. Inhibitors of JAK are associated with improved prognosis in COVID-19 patients ( 72, 129) but studies are needed to elucidate the cellular mechanisms. Synergistic activity through combinations in alternative and complementary medicine would help combat side effects associated with current monotherapies for the management of SARS-CoV-2 infections. SARS-CoV-2 is a novel virus and novel therapies may be needed to support management over time and may be of value in supporting the immune response in patients suffering from so called long-COVID. Conclusion Son D, Lee J, Lee Y, Song H, Lee C, Hong J. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther. (2007) 115:246–70. doi: 10.1016/j.pharmthera.2007.04.004 BV has been explored in cancer ( 111, 112); melittin is considered cytolytic but non-specific. Melittin can break down the membrane lipid bilayer and exhibits toxicity when injected intravenously ( 113). APi M has the ability to suppress tumor growth in breast, liver, prostate, and lung cancer cells ( 111, 112). In vitro and in vivo studies show that melittin can suppress growth of cancerous cells by inhibiting NF-κB signaling and activating caspase 3 and 9 pathways. Inhibition of hepatocellular carcinoma cell motility was observed in vitro and in vivo by suppression of Rac1-dependent pathways ( 114). Anti-inflammatory Potential

The anti-inflammatory effects of bee venom have been shown to especially benefit those with rheumatoid arthritis (RA), a painful inflammatory condition that affects your joints. When applied to the skin: There isn't enough reliable information to know if bee venom is safe or what the side effects might be. Pregnancy and breast-feeding: Bee venom is POSSIBLY SAFE when injected under the skin by a trained medical professional at recommended doses. Though harmful effects at usual doses have not been reported, some healthcare providers decrease the maintenance dose by half during pregnancy. High doses of bee venom are POSSIBLY UNSAFE during pregnancy because they can increase release of a chemical called histamine, which can cause the uterus to contract. This might lead to miscarriage. Avoid high doses of bee venom if you are pregnant. Golden DB, Kagey-Sobotka A, Lichtenstein LM. Survey of patients after discontinuing venom immunotherapy. J Allergy Clin Immunol 2000;105(2 Pt 1):385-90. View abstract. Bostanci N, Belibasakis GN. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiol Lett. (2012) 333:1–9. doi: 10.1111/j.1574-6968.2012.02579.x Sun D. Remdesivir for treatment of COVID-19: combination of pulmonary and IV administration may offer aditional benefit. AAPS J. (2020) 22:77. doi: 10.1208/s12248-020-00459-8

Sign up to our complimentary loyalty programme, NDULGE and make shopping with us even more rewarding.Wesselius T, Heersema DJ, Mostert JP, et al. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology 2005;65:1764-8. View abstract. Additionally, bee-venom therapy can cause serious side effects or even death in highly allergic individuals by causing anaphylaxis, a potentially life-threatening allergic reaction that can make it hard to breathe ( 28). de Wit E, Feldmann F, Cronin J, Jordan R, Okumura A, Thomas T, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci USA. (2020) 117:6771–6. doi: 10.1073/pnas.1922083117 that is, or may reasonably be considered to be, defamatory, libellous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation; An WW, Gong XF, Wang MW, Tashiro S, Onodera S, Ikejima T. Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK and mitochondrial pathways. Acta Pharmacol Sin. (2004) 25:1502–08. Available online at: http://www.chinaphar.com/article/view/8413/9071

Almunia C, Bretaudeau M, Held G, Babon A, Marchetti C, Castelli FA, et al. Bee venom phospholipase A2, a good “Chauffeur” for delivering tumor antigen to the MHC I and MHC II peptide-loading compartments of the dendritic cells: the case of NY-ESO-1. PLoS ONE. (2013) 8:1–17. doi: 10.1371/journal.pone.0067645In susceptible individuals, using topical bee-venom products like serums and moisturizers can also cause adverse reactions, such as itching, hives, and redness ( 30, 31). This deeply hydrating mask is the ultimate solution for dry skin. Its bee venom, manuka honey, and royal jelly formula repairs the skin's moisture barrier leaving your complexion completely refreshed and rejuvenated. Bee Venom – The venom collected from the honeybee, Apis melifera (consisting chiefly of melittin) has astringent and skin protecting qualities.