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Bower, C., D'Antoine, H., and Stanley, F. J. Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. Birth Defects Res A Clin Mol.Teratol. 2009;85(4):269-273. View abstract. Low folate levels at this important time can increase the risk of neural tube defects and possibly other problems in your baby. Boers, G. H., Smals, A. G., Trijbels, F. J., Fowler, B., Bakkeren, J. A., Schoonderwaldt, H. C., Kleijer, W. J., and Kloppenborg, P. W. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N.Engl.J Med 9-19-1985;313(12):709-715. View abstract. Allen, L. H. and Peerson, J. M. Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food Nutr Bull. 2009;30(4 Suppl):S527-S532. View abstract.
Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 5-7-2008;299(17):2027-2036. View abstract. Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. Published 2019 Apr 24. doi:10.3389/fnut.2019.00049 You might think that you can get all the folic acid and other vitamins you need from the food you eat each day. But it is hard to eat a diet that has all the nutrients you need every day. Even with careful planning, you might not get all the vitamins you need from your diet alone. That’s why it’s important to take a vitamin with folic acid every day. peringatan menyusui: Folic Acid terdistribusi ke dalam ASI, namun hanya dalam jumlah yang sangat sedikit dan relatif aman untuk bayi. Tetap konsultasikan pada dokter terlebih dahulu sebelum mengonsumsi obat ini.It’s also in dietary supplements, such as multivitamins ( 1, 4). What does the body use folate for? Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep. 1992;41(RR-14):1–7.
Depression. Taking folic acid by mouth along with antidepressants seems to improve symptoms in some people with depression. Taking 17mg or less of nicotinic acid supplements a day, or 500mg or less of nicotinamide supplements a day, is unlikely to cause any harm. Pantothenic acid This is particularly a concern for older people because it becomes more difficult to absorb vitamin B12 as you get older. What does the Department of Health and Social Care advise?Starr RR. Too little, too late: ineffective regulation of dietary supplements in the United States. Am J Public Health. 2015;105(3):478–485. doi:10.2105/AJPH.2014.302348
Arber, N., Eagle, C. J., Spicak, J., Racz, I., Dite, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., Rosenstein, R. B., Macdonald, K., Bhadra, P., Fowler, R., Wittes, J., Zauber, A. G., Solomon, S. D., and Levin, B. Celecoxib for the prevention of colorectal adenomatous polyps. N.Engl.J Med 8-31-2006;355(9):885-895. View abstract. Araki, A., Sako, Y., Fukushima, Y., Matsumoto, M., Asada, T., and Kita, T. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects. Atherosclerosis 1989;79(2-3):139-146. View abstract.
References
Bailey, L. B. Do low doses of folic acid result in maximum lowering of homocysteine? Am.J Clin.Nutr 2005;82(4):717-718. View abstract. Taking high doses of nicotinic acid supplements can cause skin flushes. Taking high doses for a long time could lead to liver damage. Weak and brittle bones ( osteoporosis). In elderly individuals with osteoporosis, taking folic acid by mouth with vitamin B12 and/or vitamin B6 does not seem to prevent broken bones. Asfour, R., Wahbeh, N., Waslien, C. I., Guindi, S., and Darby, W. J. Folacin requirement of children. III. Normal infants. Am.J.Clin Nutr. 1977;30(7):1098-1105. View abstract.