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Delusions may respond to neuroleptics (phenothiazine and butyrophenone) but these agents also may increase the chance of seizures; benzodiazepines may be useful in reducing anxiety. Reproductive effects:- On an acute basis, cocaine can prolong the time to reach orgasm in men and women. Cocaine is excreted almost exclusively in the urine, as metabolites. Only a minor fraction of cocaine is eliminated unchanged in the urine (<5%). If a sample does contain cocaine, the next question is how to test cocaine’s purity to know if it’s been cut with other ingredients. This brings us to the best cocaine purity test kits on the market in 2023. These take at-home cocaine testing to the next level by telling you not only if cocaine is present in a sample, but also giving you an idea of how pure that cocaine is. This is key to not getting ripped off, as well as staying safe by not ingesting unknown substances. If you’d like to know what specific substances were used to cut your cocaine, move on to the next section, Cocaine Cuts Test Kits.

Cocaine Identification Kits: These cocaine test kits simply give you a yes/no answer as to whether a substance contains cocaine. They won’t give you any indication of how pure your cocaine is or whether there are additional substances cut into it. Cocaine applied to the mucous membranes may be detectable for as long as three hours after its application. A true biological half-life for cocaine is difficult to ascertain, as serum concentrations reflect a dynamic balance between the absorption and degradation of cocaine, i.e. the concentration of cholinesterase in the blood can vary between individuals. Cocaine should be used with caution in patients with hypertension, cardiovascular disease or thyrotoxicosis because the vasoconstriction and tachycardia may reduce cardiac oxygenation while increasing oxygen demand It should also be used with caution in patients with diabetes because cocaine sensitises the person to adrenaline which mobilises glucose and causes blood glucose levels to go out of control.Cocaine hydrochloride causes numbness and vasoconstriction (narrowed blood vessels), which can reduce bleeding and swelling on the operating area.

The use of cocaine in the elderly is not recommended because of the risk of vasoconstriction and tachycardia. Cocaine is also not recommended in children, or in pregnancy or lactation. A common misconception is that if taken orally, cocaine is rendered ineffective by gastric acidity.In a medical setting where cocaine is used, positive-pressure breathing equipment should be functional and easily accessible, and intravenous diazepam should be immediately available. Cocaine is metabolized by two major hydrolytic pathways. Cocaine is metabolized by hydrolysis to benzoylecgonine (major, but inactive metabolite) by hepatic carboxylesterase-1. Cocaine is also metabolized by hydrolysis to ecgonine methyl ester (major, but inactive metabolite) by plasma butyrylcholinesterase and hepatic carboxylesterase-2. Cocaine has seen both legal and illegal drug use ever since it was discovered. Today, its use is heavily regulated in the United States. History Of The Legal Use Of Cocaine