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Having big boobs can be a blessing and a curse — as one woman found out when she attempted to do a week without wearing a bra. Another clip shows how her bosom makes it difficult for Billie — who goes by @billiebopbillie online — to comfortably fit into a dress. The PI3K–AKT–mTOR signaling pathway is one of the most frequently de-regulated pathways in human cancers 41, with repercussions in key cellular processes, such as metabolism, independent cell proliferation, cell invasion, endocrine receptor deregulation and resistance to therapy 45, and consequently supporting cancer cell programs. The pathway can be aberrantly activated through multiple mechanisms, including diverse AKT mutations 46. E17K mutation activates AKT1 by recruiting it to the membrane through a PI3K-independent mechanism, resulting in the activation of PI3K/AKT/mTOR signaling pathway 47. Thus, AKT1 mutations have emerged as an attractive druggable target and there is promising clinical data in ER + ductal BC patients harboring AKT1 E17K mutation treated with the pan-AKT targeted inhibitors AZD5363, MK-220 46, 48 and ipatasertib, another ATP-competitive AKT inhibitor 49.

Goldhirsch, A. et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann. Oncol. 24, 2206–2223 (2013). Mallucm3i, P. and Branford, O.A. (2012) Concepts in Aesthetic Breast Dimensions: Analysis of the Ideal Breast. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS, 65, 8-16. Fresno C., Gonzalez G. A., Llera A. & Fernandez E. pbcmc: Permutation-Based Confidence for Molecular Classification. http://www.bdmg.com.ar/ (2016). Kan, Z. et al. Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures. Nat. Commun. 9, 1725 (2018). Laboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoThe elements and perception of beauty vary between populations around the world. Understanding the aesthetics of the body continues to be a work in progress, demonstrated by the multiple descriptions that have characterized different civilizations for centuries [1]. Since the old days, Greeks, Romans, painters, and sculptors have relied heavily on observation as their main tool to establish the aesthetically pleasing proportions [2]. Reynoso-Noveron, N. et al. Clinical and epidemiological profile of breast cancer in mexico: results of the seguro popular. J. Glob. Oncol. 3, 757–764 (2017).

Published studies have demonstrated anatomical differences between races [5] [6]. For this reason we believe that a surgical procedure and the end results, should not be evaluated with the same parameters in an Asian, European, or Mexican patient. After searching the main international databases, we have no knowledge of any Breast Anthropometric studies performed on Mexican population. Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat. Biotechnol. 31, 213–219 (2013). With the current state of events, celebrating women's bodies is as important as ever. But for BAZAAR, championing curves of every size has always been a priority. As we reflect on some of the best breast moments in the title's history, both understated and overt, it has become clearer with every shot that the feminine anatomy, no matter which way that you look at it, is a work of art.The mean values for the Base of the Breast divided by age group were 3rd decade of life (12.6 cm, L 12.6 cm), Fourth decade of life (R 12.7 cm, L 12.8 cm), Fifth decade of life (R 14.9 cm, L 14.7 cm), >6 th decade of life (R 14.8 cm, L 15.1 cm) ( Figure 7). We found that the average base of the breast in the Mexican population is 13.4 cm, regardless of the side (p < 0.490) ( Table 4).