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Beaphar Fipronil Spray 2.5 mg/ml - Skin Spray Solution for Dogs and Cats - Works Against Fleas, Ticks and Crusher Lice - 100 ml Bottle

£9.9£99Clearance
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When using a pipette, spread the drops directly onto the skin by parting the hair between your pet's shoulder blades and at the base of the neck. Chicken eggs were found to contain fipronil and distributed to 15 European Union countries, Switzerland, and Hong Kong. Recommended for treating cats and dogs weighing no more than 10kg, due to the number of sprays required to treat animals weighing more than this. This product eliminates fleas with a single contact and protects against fleas for 2 months and ticks and lice for 4 weeks. Fipronil disrupts the insect central nervous system by blocking the ligand-gated ion channel of the GABA A receptor and glutamate-gated chloride (GluCl) channels.

Fipronil may be quantitated in plasma by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. The United States Environmental Protection Agency has classified fipronil as a group C (possible human) carcinogen based on an increase in thyroid follicular cell tumors in both sexes of the rat. Fipronil's specificity towards insects is believed to be due to its greater binding affinity to the GABA A receptors of insects, than to those of mammals, and to its action on GluCl channels, which do not exist in mammals. In recent years new products have reached the market which are faster acting, easier to administer, and provide longer protection. Fipronil General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services.Fipronil belongs to the phenylpyrazole class and interacts with GABA receptors which results in the death of parasites. Marketed under the names Termidor, Ultrathor, Fipforce and Taurus in Africa and Australia, fipronil controls termite pests, and was shown to be effective in field trials in these countries.

Also, adverse effects were indicated in the short term on several other invertebrate groups, one species of lizard ( Trachylepis elegans), and several species of birds (including the Madagascar bee-eater). And a recent study published in 2016 found that no significant reduction in the susceptibility of fleas to fipronil. Jacob, Cynthia Renata Oliveira; Soares, Hellen Maria; Carvalho, Stephan Malfitano; Nocelli, Roberta Cornélio Ferreira; Malaspina, Osmar (2013).

Approximately 3 ml/kg is needed for short-haired cats, and up to twice that amount, 6 ml/kg, for long-haired cats.

Commercial pet groomers and veterinary physicians were considered to be at risk from chronic exposure via inhalation and dermal absorption during the application of the spray, assuming they may have to treat up to 20 large dogs per day. Frontline Spray is a solution for controlling and preventing flea and tick infestations in dogs and cats. When an insect comes into contact with fipronil, it acts on their central nervous system by triggering all the nerve endings to act constantly. Only tiny amounts of fipronil are required because it acts on an incredibly minute molecular level, and flea and tick’s nervous systems are not big. Frontline Spray comes in various sizes and preparations; Frontline Spray, Frontline Spot On, and Frontline Combo Spot On.An early-lifestage toxicity study in rainbow trout found that fipronil affects larval growth with a NOEC of 0. Don’t use a fipronil for dogs product if you have already used another flea or tick treatment in the last month. Manufactured by Merial Animal Health, Frontline Spray is a liquid medication used for the prevention of ticks, fleas, and other parasites. In this AnimalWised article, we explain what Fipronil is in cats, what it is used for, how it is dosed, and its side effects. Fipronil acts by binding to allosteric sites of GABA A receptors and GluCl receptors (of insects) as an antagonist (a form of noncompetitive inhibition).

Since 2003, BASF holds the patent rights for producing and selling fipronil-based products in many countries. Some of our partners may process your data as a part of their legitimate business interest without asking for consent. Beaphar FIPROtec® Spray is an effective veterinary strength medicine to control fleas, ticks and biting lice on kittens, puppies, cats and dogs.Fipronil is also used in Brazil and studies on the stingless bee Scaptotrigona postica have shown adverse reactions to the pesticide, including seizures, paralysis, and death with a lethal dose of . When applied as directed by your vet, the active ingredient in Frontline, Fipronil, helps to bring infestations under control. Acute studies of estuarine animals using oysters, mysids, and sheepshead minnows show that fipronil is highly acutely toxic to oysters and sheepshead minnows, and very highly toxic to mysids. The main ingredient in the composition of Frontline Spray is fipronil which is an insecticide used to treat fleas, ticks, and lice. Fipronil does not treat flea- or tick-borne diseases, but there is some early evidence to suggest that fipronil can inhibit the transmission of Lyme disease and canine ehrlicosis from tick to dog in the first place (it’s not understood how yet).

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