Enterosgel Sachets (1 pack) - Relief from IBS Symptoms: Diarrhoea, Abdominal Pain, Bloating, Urgency | Travellers Diarrhoea Relief

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Analyses were performed using SPSS V.25 and STATA/SE V.14.0. The baseline characteristics of the groups were summarised as mean (SD) and median (IQR) by trial arm. Enterosgel contains unique, porous molecules, which pass gently through the gut without being absorbed themselves. The pore size of these molecules is designed to selectively attract and bind harmful particles on its surface, without removing beneficial substances such as water or vitamins. How effective is Enterosgel? This was a randomised, controlled, multicentre pragmatic study to assess efficacy, tolerability and safety of Enterosgel in the treatment of acute diarrhoea in adults compared with standard care. In line with many medical device studies, the use of a placebo is rare, most studies compare to approved therapies. The specific gel-like formulation and organoleptic properties of Enterosgel are difficult to simulate in a placebo, which is both safe and has no impact on the study outcomes. Hence, this was a pragmatic study utilising patient-reported outcomes compared with NICE guidance standard of care.

Enterosgel - Boots Enterosgel - Boots

Enterosgel ® has a porous structure of hydrophobic organic silicon matrix (molecular sponge) that sorbs mostly medium molecular toxic metabolites (m.m. 70–1,000). The medicinal product has pronounced sorption and detoxification properties. In the intestinal lumen, it binds endogenous and exogenous toxic substances of various nature, including bacteria and bacterial toxins, antigens, food allergens, drugs and poisons, salts of heavy metals, radionuclides, alcohol and removes them from the body. Enterosgel® also sorbs some metabolic waste, including excess bilirubin, urea, cholesterol and lipid complexes, as well as metabolites responsible for endogenous toxicosis. Enterosgel ® does not reduce absorption of vitamins and trace elements, it helps restore the damaged intestinal microflora. Enterosgel ® does not affect gastrointestinal motor function. Pharmacokinetics In young children with acute infectious diarrhoea, it is important to provide rehydration therapy. Although ORS can alleviate dehydration, it has no effect on the duration of diarrhoea or abdominal pain. 5 Thus, Enterosgel may have an additional benefit, especially in vulnerable groups; for example, children and elderly or immunocompromised/renal dialysis/receiving chemotherapy where more rapid resolution of diarrhoeal symptoms could have a beneficial impact on health. Another fascinating thing about Enterosgel is that you can take it together with other supplements and medications. But, when taking other medicines, take them 1-2 hours before or after Enterosgel. Your doctor or pharmacist can provide further advice.

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The secondary outcome, safety and tolerability, of Enterosgel was confirmed, as there were no SAE or serious adverse device effect in the Enterosgel arm. Furthermore, none of the patients had an unscheduled visit to their General Practitioner (GP) where the reason for visit was an AE related to intestinal infection. There was one control group patient that had a serious adverse diarrhoea-related complication that resulted in hospitalisation. There were five transient mild AEs possibly relating to the investigational device. These included constipation and nausea, known infrequent possible side effects which are currently listed in the Instruction for Use, whereas burping and indigestion have not previously been recorded as side effects and could be linked to the underlying condition. The study provides evidence that Enterosgel reduces diarrhoea duration in patients with acute diarrhoea of infectious or non-infectious aetiology. Primary outcome of duration of diarrhoea to first non-watery stool showed a statistically significant decrease (p=0.03) in the Enterosgel group, which corresponds to a 64% chance of the Enterosgel subject's diarrhoea resolving first compared with standard therapy alone. The proportion whose diarrhoea had resolved at 12, 24 and 36 hours was comparatively higher in the Enterosgel group at each time interval. As all efficacy and safety data were recorded in patient diaries, the study outcomes were not subject to assessor bias and outcomes were standardised to minimise any bias resulting from the subjects being unblinded. The number needed to treat, for resolution of diarrhoea at 12 hours, was estimated at 4.98, which equates to one extra patient with diarrhoea resolved at 12 hours for every 4.98 patients treated with Enterosgel. Yes, Enterosgel is a drug-free mineral gel, which is not absorbed into the body and doesn’t contain any preservatives, so Enterosgel is suitable for pregnant and breastfeeding women. It is always important to consult with your GP or midwife if you are unwell during pregnancy or breastfeeding.

Enterosgel for the treatment of adults with acute diarrhoea Enterosgel for the treatment of adults with acute diarrhoea

Rest assured, Enterosgel is a safe and reliable treatment suitable for the entire family, including children as young as 0 years old. Experience the relief and regain control of your digestive health with Enterosgel today. Benefits of Using Enterosgel: IBS – Enterosgel can normalise stool frequency and provide relief from constipation, one of the issues associated with irritable bowel symptom. The Microflora is paramount when it comes to gut health and Enterosgel helps to regulate and protect it. Directions: As a food supplement, Enterosgel should be given 1-2 hours before or after a meal, or as directed by your healthcare professional. Competing interests CAH and EM are employees of Enteromed Ltd, the sponsor of the study. PP, VA, AK and RA have no conflicts of interest to declare. AVK is an employee of TNK SILMA LLC, manufacturer of Enterosgel in Russia.Enterosgel is CE certified medical device that is composed of an organic mineral and water (70% Polymethylsiloxane polyhydrate and 30% Purified water). Enterosgel does not contain substances that can cause allergic or toxic reactions. It is free from preservatives, gluten, dairy, sugar, flavours or colouring. Enterosgel is an oral adsorbent, typical of several materials, such as charcoal, clay, silica-based materials and dietary fibres used to treat poisoning and different diseases, such as diarrhoea. 15 The therapeutic mode of action of Enterosgel may occur through the adsorption of bacterial toxins known causes of diarrhoea followed by complete removal from the body. In-vitro studies have demonstrated Enterosgel’s capacity for Escherichia coli endotoxin, bacterial enterotoxins Clostridium difficile toxin A and B, and Shigella toxin 16 and staphylococcal enterotoxins A and B. 17 Other mechanisms may include creation of an adverse environment for pathogenic microorganisms, 18 immunocorrection 19 and inhibiting viral replication, 20 primarily through physical adsorption. A possible benefit of Enterosgel use is in reducing the level of complications of diarrhoea-related bacterial infection. Prospective studies have shown that up to 36% of intestinal infections can be followed by prolonged post-infective irritable bowel syndrome. 21 Thus, treatment with Enterosgel could offer a reduction in secondary care admissions, and financial burden on the health service. However, a large-scale study is recommended with health economics evaluation before introducing Enterosgel onto the UK’s drug tariff.

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Enterosgel is a versatile product, which can be used for a wide range of health problems, from IBS and food poisoning to skin complaints and hayfever. I’ve certainly got a tube in my first aid cupboard ready for use when needed. Enterosgel ® is taken orally 1-2 hours before or after meals or administration of other medicines with water. For children 1-6 years old*: 5g (1 teaspoon or 1/3 of a sachet) diluted in 50-100ml of water 3 times a day. Take the necessary dose of ENTEROSGEL® after the first loose stool. Take ENTEROSGEL® at least 2 hours before or after taking oral medications. Take ENTEROSGEL® at least 1–2 hours before or after meal. Dilute the dose in the water of room temperature before its administration. Use sachet immediately after opening. Many clinical studies in both adults and children have shown that it is a safe and effective treatment. Two of these studies have been completed in the UK. The first was a randomised controlled trial investigating Enterosgel® for the treatment of acute diarrhoea in adults recruited from GP surgeries. This showed that Enterosgel significantly reduced the duration of diarrhoea in patients that either had a gastrointestinal infection or other causes for their short-term diarrhoea.Part of complex therapy of acute intestinal infections of any origin (toxic infection, salmonellosis, dysentery, non-infectious diarrhoea, dysbacteriosis);