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Vape Blue Elf Bar Disposable Vape, 600 Puffs, Zero Nicotine, Pack of 4, Blueberry, Cherry, Watermelon, Grape

£9.9£99Clearance
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Nicotine: Biological activity". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology . Retrieved 7 February 2016. K is as follows; α2β4=9900nM [5], α3β2=14nM [1], α3β4=187nM [1], α4β2=1nM [4,6]. Due to the heterogeneity of nACh channels we have not tagged a primary drug target for nicotine, although the α4β2 is reported to be the predominant high affinity subtype in the brain which mediates nicotine addiction

Nicotine has been shown to produce birth defects in some animal species, but not others; [41] consequently, it is considered to be a possible teratogen in humans. [41] In animal studies that resulted in birth defects, researchers found that nicotine negatively affects fetal brain development and pregnancy outcomes; [41] [39] the negative effects on early brain development are associated with abnormalities in brain metabolism and neurotransmitter system function. [116] Nicotine crosses the placenta and is found in the breast milk of mothers who smoke as well as mothers who inhale passive smoke. [117] Spasova V, Mehmood S, Minhas A, et al. Impact of nicotine on cognition in patients with schizophrenia: A narrative review. Cureus. 2022;14(4):e24306. doi:10.7759/cureus.24306

Are Elf Bars Worse Than Cigarettes?

Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) [7] and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. [8] [5] [9] [10] Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), [11] [12] [13] except at two nicotinic receptor subunits ( nAChRα9 and nAChRα10) where it acts as a receptor antagonist. [11] Heishman SJ, Kleykamp BA, Singleton EG (July 2010). "Meta-analysis of the acute effects of nicotine and smoking on human performance". Psychopharmacology. 210 (4): 453–69. doi: 10.1007/s00213-010-1848-1. PMC 3151730. PMID 20414766. a b c d e f g h i j "Nicotine". United States National Library of Medicine– Toxicology Data Network. Hazardous Substances Data Bank. 20 August 2009. There are more than 30 original Elfbar flavours across the range, including various fruit, tobacco and mint flavours. Mishra S, Mishra MB. Tobacco: Its historical, cultural, oral, and periodontal health association. J Int Soc Prev Community Dent. 2013;3(1):12-18. doi:10.4103/2231-0762.115708

Although nicotine itself does not cause cancer in humans, [38] it is unclear whether it functions as a tumor promoter as of 2012 [update]. [102] A 2018 report by the US National Academies of Sciences, Engineering, and Medicine concludes, "[w]hile it is biologically plausible that nicotine can act as a tumor promoter, the existing body of evidence indicates this is unlikely to translate into increased risk of human cancer." [103]Two hours after ingesting nicotine, the body will have removed around half of the nicotine. This means that nicotine has a half-life of around 2 hours.

European Food Safety Authority (7 May 2009). "Potential risks for public health due to the presence of nicotine in wild mushrooms". EFSA Journal. 7 (5): 286r. doi: 10.2903/j.efsa.2009.286r. Abou-Donia M (5 February 2015). Mammalian Toxicology. John Wiley & Sons. pp.587–. ISBN 978-1-118-68285-2.Elf Bar Zero Cranberry Grape: Indulge in the perfect harmony of Cranberry Grape. Tart cranberries intertwine with luscious grapes, crafting a balanced and delightful vaping experience. Nathisuwan S, Dilokthornsakul P, Chaiyakunapruk N, Morarai T YT, Piriyachananusorn N. Assessing evidence of interaction between smoking and warfarin: a systematic review and meta-analysis. Chest 2011;139(5).

The initial symptoms of a nicotine overdose typically include nausea, vomiting, diarrhea, hypersalivation, abdominal pain, tachycardia (rapid heart rate), hypertension (high blood pressure), tachypnea (rapid breathing), headache, dizziness, pallor (pale skin), auditory or visual disturbances, and perspiration, followed shortly after by marked bradycardia (slow heart rate), bradypnea (slow breathing), and hypotension (low blood pressure). [41] An increased respiratory rate (i.e., tachypnea) is one of the primary signs of nicotine poisoning. [41] At sufficiently high doses, somnolence (sleepiness or drowsiness), confusion, syncope (loss of consciousness from fainting), shortness of breath, marked weakness, seizures, and coma may occur. [6] [41] Lethal nicotine poisoning rapidly produces seizures, and death– which may occur within minutes– is believed to be due to respiratory paralysis. [41] Toxicity [ edit ] a b "Nicotine". European Chemicals Agency: Committee for Risk Assessment. September 2015 . Retrieved 23 January 2019.Nicotine was often compared to caffeine in advertisements in the 1980s by the tobacco industry, and later in the 2010s by the electronic cigarettes industry, in an effort to reduce the stigmatization and the public perception of the risks associated with nicotine use. [195] Research [ edit ] Central nervous system [ edit ] a b Grana R, Benowitz N, Glantz SA (May 2014). "E-cigarettes: a scientific review". Circulation. 129 (19): 1972–86. doi: 10.1161/circulationaha.114.007667. PMC 4018182. PMID 24821826.

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