PATCH PRO MICRO NEEDLE PATCH 8pcs, self-dissolving microneedle patch, facial anti-wrinkle patches, crosslinked hyaluronic acids for forehead lines, smile line, fine line, eye wrinkle, Puffy eyes

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Microneedle patches can also be used to deliver targeted treatments, such as hydrating hyaluronic acid and anti-ageing peptides, deeper into the skin rendering them even more effective. How Safe Are Microneedle Patches? The researchers showed that their new dye, which consists of nanocrystals called quantum dots, can remain for at least five years under the skin, where it emits near-infrared light that can be detected by a specially equipped smartphone. Anyone with acne prone skin needs to be careful of microneedling using a dermaroller as these devices can spread the acne causing bacteria around the skin, and potentially cause acne spots to spread. Zhan Y, Xu X, Luo X, Liu R, Lin Y, Zhao P, Shi J. Zhan Y, et al. Chin Herb Med. 2023 Jan 18;15(2):251-262. doi: 10.1016/j.chmed.2022.10.002. eCollection 2023 Apr. Chin Herb Med. 2023. PMID: 37265770 Free PMC article. Lopman, B. A. et al. Understanding reduced rotavirus vaccine efficacy in low socio-economic settings. PLoS ONE 7, e41720 (2012).

Progress in microneedle array patch (MAP) for vaccine delivery Progress in microneedle array patch (MAP) for vaccine delivery

MIT researchers have now developed a novel way to record a patient’s vaccination history: storing the data in a pattern of dye, invisible to the naked eye, that is delivered under the skin at the same time as the vaccine. There are many advantages to the use of microneedles, the most prominent being the improved comfort of patients. Needle phobia can affect both adults and children, and sometimes can lead to fainting. The benefit of microneedle arrays is that they reduce anxiety that patients have when confronted with a hypodermic needle. In addition to improving psychological and emotional comfort, microneedles have been shown to be substantially less painful than conventional injections. [9] Some studies recorded children's views on blood sampling with microneedles and found patients were more willing when prompted with a less painful procedure than traditional sampling with needles. Microneedles are beneficial to physicians as well, since they produce less hazardous waste than needles and are generally easier to use. Microneedles are also less expensive than needles as they require less material and the material used is cheaper than the materials in hypodermic needles. Rahamathulla M, Murugesan S, Gowda DV, Alamri AH, Ahmed MM, Osmani RAM, Ramamoorthy S, Veeranna B. Rahamathulla M, et al. AAPS PharmSciTech. 2023 Oct 19;24(8):216. doi: 10.1208/s12249-023-02661-1. AAPS PharmSciTech. 2023. PMID: 37857918 Review. John, J. et al. The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomized controlled trial. J. Infect. Dis. 215, 529–536 (2017). Injections are invasive and expensive, and they don’t suit everyone. A lot of people are needle-phobic and are understandably reluctant to receive medicine by injection even when treatment is really needed. Others are ill-suited to injections – for instance, elderly patients with thin skin," she said.Preclinical studies with the SARS-CoV-2 HexaPro modified spike protein 24 have shown that the protein can be formulated, dried, and stabilized on the HD-MAP. 21 In a mouse model, delivery of HexaPro on the HD-MAP was superior to intradermal (ID) delivery with N&S, inducing high titers of antibodies capable of neutralizing a range of SARS-CoV-2 VoCs, including Alpha and Beta. 25 In a transgenic mouse model, vaccination with a single dose of HexaPro plus the adjuvant QS21 on HD-MAPs elicited 100% protection from a lethal SARS-CoV-2 virus challenge. Without the adjuvant, two doses of HexaPro were sufficient for protection. 25 Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery.

Microneedle patches for potential COVID-19 vaccines or Microneedle patches for potential COVID-19 vaccines or

Alafnan A, Seetharam AA, Hussain T, Gupta MS, Rizvi SMD, Moin A, Alamri A, Unnisa A, Awadelkareem AM, Elkhalifa AO, Jayahanumaiah P, Khalid M, Balashanmugam N. Alafnan A, et al. Materials (Basel). 2022 Nov 1;15(21):7693. doi: 10.3390/ma15217693. Materials (Basel). 2022. PMID: 36363283 Free PMC article. It's the rare individual who actually looks forward to getting jabbed with a needle, even if what's in the needle can protect them from a serious disease such as COVID-19. CDC-9, a human G1P[8] RV strain, was cultivated in Vero cells and triple-layered particles (TLPs) and double-layer particles (DLPs) were purified from cell supernatants by using CsCl gradient centrifugation 38. The ratio of TLPs and DLPs was approximately 9:1 as measured by protein concentration with a Bradford assay. TLPs and DLPs in 50 mM HEPES, 150 mM NaCl, 5 mM CaCl 2 [pH 7.2-7.5] supplemented with 7% D-sorbitol were inactivated at 62 °C for 6 h and protein concentration was determined by Pierce™ Coomassie Bradford protein assay kit (Thermo Fisher Scientific, IL, USA) before being used for the fabrication of dMNP. Mono-bulks containing approximately 900, 450, and 650 DU/ml of IPV types 1, 2, and 3, were donated by GlaxoSmithKline, and were concentrated approximately 150, 100, and 75-fold by volume, respectively, and suspended in 0.375 mM histidine buffer (J.T. Baker ®, PA, USA). Mono-bulk concentration and buffer exchange were performed using Amicon Ultra centrifuge spin filters with 100 kDa MW cutoff at 4 °C, 4000 × g (Millipore Sigma, MA, USA). D-antigen contents were determined by ELISA 39. Dissolving microneedle patch (dMNP) fabrication BALB/C mice were injected intraperitoneally with LPS (1 μg g −1) to induce an acute phase response and systemic inflammation. Using functionalized microneedle patches, we measured the longitudinal concentrations of mouse IL-6 in ISF, which is known to increase in serum over 4 h after LPS administration 34. Microneedle patches, pre-functionalized with IL-6-capture antibodies, were administered at different time points on mouse ventral skin and leWhat makes the microneedle patches unique is that they are made from a hydrogel (a gel-like substance in which water forms the liquid component), with the active ingredient encapsulated inside the hydrogel microneedle structure rather than in a separate reservoir.

Storing medical information below the skin’s surface | MIT

Vaccine development is branching out from the time-tested methods of using live attenuated strains of the disease-causing agent, or a part of the virus which is antigenic, to recombinant vaccines that depend on the production of viral antigens by bacterial or yeast cells into which the genes encoding these antigens are inserted. Another approach is to create vaccines from the genetic code of the virus itself. Wang, Y. et al. Inactivated rotavirus vaccine induces protective immunity in gnotobiotic piglets. Vaccine 28, 5432–5436 (2010). In areas where paper vaccination cards are often lost or do not exist at all, and electronic databases are unheard of, this technology could enable the rapid and anonymous detection of patient vaccination history to ensure that every child is vaccinated,” says Kevin McHugh, a former MIT postdoc who is now an assistant professor of bioengineering at Rice University.The researchers believe the quantum dots are safe to use in this way because they are encapsulated in a biocompatible polymer, but they plan to do further safety studies before testing them in patients.