Optibac Probiotics Bifido & Fibre - Vegan Digestive Probiotic Supplement with FOS Fibre to Maintain Regularity & 25 Billion Bacterial Cultures - 30 Sachets

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Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. View abstract. Turroni, F. et al. Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci USA 107, 19514–19519, doi: 10.1073/pnas.1011100107 (2010).

Ogata T, Nakamura T Anjitsu K Yaeshima T Takahashi S Fukuwatari Y Ishibashi N Hayasawa H Fujisawa T Iino H. Effect of Bifidobacterium longum BB536 administration on the intestinal environment, defecation frequency and fecal characteristics of human volunteers. Biosci Microflora 1997;16:53-58. Xiao, J. Z., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, K., and Enomoto, T. Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial. J Investig.Allergol.Clin.Immunol. 2006;16(2):86-93. View abstract.Chouraqui, J. P., Grathwohl, D., Labaune, J. M., Hascoet, J. M., de, Montgolfier, I, Leclaire, M., Giarre, M., and Steenhout, P. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am.J Clin.Nutr. 2008;87(5):1365-1373. View abstract. Quigley E.M. et al (2005), ‘Who is the responder to probiotic therapy in IBS? Data from a controlled clinical trial with Bifidobacterium infantis35624’, Am J Gastroenterol., 100(9) Suppl:A325-326 Akatsu, H., Iwabuchi, N., Xiao, J. Z., Matsuyama, Z., Kurihara, R., Okuda, K., Yamamoto, T., and Maruyama, M. Clinical Effects of Probiotic Bifidobacterium longum BB536 on Immune Function and Intestinal Microbiota in Elderly Patients Receiving Enteral Tube Feeding. JPEN J Parenter Enteral Nutr 11-27-2012; View abstract. Goodman C, Keating G, Georgousopoulou E, Hespe C, Levett K. Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. BMJ Open 2021;11(8):e043054. View abstract.

Bifidobacterium animalis subsp. lactis (B. lactis) is a type of probiotic ("good" bacteria) that lives in the intestines. It produces lactic and acetic acid. Ogata T, Kingaku M Yaeshima T Teraguchi S Fukuwatari Y Ishibashi N Hayasawa H Fujisawa T Lino H. Effect of Bifidobacterium longum BB536 yogurt administration on the intestinal environment of healthy adults. Microb Ecol Health Dis 1999;11:41-46. Gill, S. R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355–1359, doi: 10.1126/science.1124234 (2006). Sommerfield D. et al (2005), ‘Effect of probiotic feeding on Salmonellatranslocation in a Mouse model’, Gastroenterology,128:A120. (Abstract 770)

Publisher’s Note

Jiao X, Fu MD, Wang YY, Xue J, Zhang Y. Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants: a systematic review and meta-analysis. World J Pediatr. 2020;16(2):135-142. View abstract. Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis. 2017 Oct 19. [Epub ahead of print]. View abstract. Charbonneau D.L. et al (2005d), ‘Fecal flora effects following oral supplementation with Bifidobacteria infantis35624 in healthy and IBS subjects’, Can J Gastroenterol. 19 (Suppl SB) pp.R1097.

Kageyama T, Nakano Y Tomoda T. Comparative Study on Oral Administration of Some Bifidobacterium Preparations. Medicine and Biology(Japan) 1987;115(2):65-68. Davies J.M, et al (2009), ‘Bacterial signalling overrides cytokine signalling and modifies dendritic cell differentiation’, Immunology, 128 (1 Suppl)

Summary and Future Perspective

Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):132-52. View abstract. Airaksinen K, Yeung N, Lyra A, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes 2019;10(6):617-627. View abstract. Yaeshima T, Takahashi S Matsumoto N Ishibashi N Hayasawa H Lino H. Effect of yogurt containing Bifidobacterium longum BB536 on the intestinal environment, fecal characteristics and defecation frequency: A comparison with standard yogurt. Biosci Microflora 1997;16:73-77. We surveyed the presence of bifidobacterial genes into the microbial diversity of the healthy gut of 44 adults and nine infants. To this end we implemented a mapping-based pipeline to detect the presence and quantify the coverage of these gene categories annotated from the newly sequenced strains into the Illumina deep shotgun-sequenced metagenomic data sets derived from stool samples of the Human Microbiome Project (HMP) 19 and into Illumina deep shotgun-sequenced metagenomic and metatranscriptomic data sets obtained from stool samples of nine healthy infants. The mapping was performed using BowTie2 41 using multiple-hit mapping and “very-sensitive” policy. The mapping was post-processed with a custom script to retain those matches with at least 98% full-length identity with respect to at least one reference gene by threshold-ing the BowTie2 score at −12 for the 100 nt-long adults and infant datasets (−6 is the penalty for a high-quality mismatch). Genes covered by matching reads for less than 90% of their full length were discarded and the final gene-wise average coverage was computed using SAMtools 42 and BEDtools 43. In the final matrices, GHs genes and genes constituting carbohydrate-degrading pathways were collapsed into GH families and MetaCyc pathways. The estimation of the relative abundance of bifidobacteria (at the genus level) was performed with MetaPhlAn 34. Data Deposition Namba, K., Hatano, M., Yaeshima, T., Takase, M., and Suzuki, K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci.Biotechnol.Biochem. 2010;74(5):939-945. View abstract.