Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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Birt DF, Hendrich S, Wang W Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther. (2001)

Smiljkovic M, Stanisavljevic D, Stojkovic D, Petrovic I, Marjanovic Vicentic J, Popovic J, Golic Grdadolnik S, Markovic D, Sankovic-Babice S, Glamoclija J, Stevanovic M, Sokovic M Apigenin-7-O-glucoside versus apigenin: Insight into the modes of anticandidal and cytotoxic actions. EXCLI J. (2017) Lin CM, Chen CT, Lee HH, Lin JK Prevention of cellular ROS damage by isovitexin and related flavonoids. Planta Med. (2002-Apr)Its effects in animals have been thoroughly studied, while few human studies testing this substance exist. Nevertheless, preliminary research on apigenin has observed potential anti-inflammatory, antioxidant, and anticancer properties. Health Benefits of Apigenin Sun Y, Zhao R, Liu R, Li T, Ni S, Wu H, Cao Y, Qu Y, Yang T, Zhang C, Sun Y Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism. ACS Omega. (2021-Apr-06) FOCUS ON BLOOD LIPID LEVELS: May boost regulatory proteins including Steroidogenic Acute Regularity Protein (StAR) which can support blood glucose or lipid levels. The reported biological functions of apigenin include anti-oxidant, anti-mutagenic, anti-carcinogenic, anti-inflammatory, anti-proliferative, and anti-progression [ 9]. Apigenin is a moderate anti-oxidant compound because the double bond at the 2,3 carbon makes the structure more reactive, despite the absence of the hydroxyl group at position 3 and a catechol structure in the B-ring [ 83, 84]. Apigenin is a very effective anti-inflammatory agent compared to other flavonoids. Apigenin was the most potent inhibitor of transcriptional activation of both inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 cells among flavonoids such as wogonin, luteolin, tectorigenin, kaempferol, and quercetin, etc., reducing the production of nitric oxide [ 85, 86]. Apigenin also suppressed nitric oxide production in LPS/gamma-interferon (IFN- γ) stimulated C6 astrocyte cells in a dose-dependent manner with an IC 50 less than 10 −3M [ 87]. When tested to see if flavonoids could inhibit LPS-induced TNF- α secretion in primary bone marrow-derived mouse macrophages, apigenin was not as effective as quercetin, luteolin, or genistein, but was similar to kaempferol, diosmetin, and hesperetin. It seems that the double bond at C 2-C 3 and the position of the B-ring at 2 contribute to the high anti-inflammatory effect [ 88]. Apigenin inhibits the production of proinflammatory cytokines IL-1 β, IL-8, and TNF in lipopolysaccharide-stimulated human monocytes and mouse macrophages in vitro (concentrations 0.1-25 μM or 0.027-6.756 μg/mL) [ 89]. It also inhibited TNF-induced NF- κB transcriptional activation in NIH/3T3 cells (concentrations 10-30 μM or 2.702-8.107 μg/mL) [ 90]. Carrageenan can induce acute paw edema in mice, and the inflammation could be alleviated by apigenin [ 90]. Apigenin exhibited an anti-inflammatory effect on murine microglia cell line by reducing the production of nitric oxide and prostaglandin E 2 and was found to be protective against ischemia in neuronal cells (concentrations 1-10 μM or 0.270-2.702 μg/mL) [ 91]. Apigenin exhibited the highest DNA protective effects against free radicals generated by Fe 2+ among luteolin and quercetin at the concentration of 1 μM in vitro, which indicated its function as an antioxidant (concentration at 10 μM or 2.702 μg/mL) [ 92]. The anti-inflammatory activity of apigenin has also been reported in lipopolysaccharide-induced inflammation in acute lung injury in situ (concentrations 10 and 20 mg/kg body weight) [ 93].

Apigenin is an antioxidant compound that naturally occurs in plants. It can be found in fruits and vegetables, such as parsley, onions, oranges, tea, chamomile, wheat sprouts, and some seasonings. Outside of its biological effects, it is a yellow crystalline that is typically used to dye garments.In mice given a lethal dose of bacterial lipopolysaccharides, apigenin decreased cell death and controlled the inflammatory immune response in affected areas [ 13]. Raul Zamora-Ros, David Achaintre, Joseph A Rothwell, Sabina Rinaldi, Nada Assi, Pietro Ferrari, Michael Leitzmann, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Aurélie Auffret, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Effie Vasilopoulou, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, Nadia Slimani, Isabelle Romieu, Augustin Scalbert Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study Sci Rep. (2016 Jun 7) Candida albicans ATCC 10231 and C. parapsilosis ATCC 22019 were reported to be inhibited by apigenin with MIC of 8 and 16 μg/mL, respectively [ 100]. Apigenin could be used as an antifungal agent in the clinical treatment of dermatophytosis [ 125]. Mice were experimentally induced to develop dermatophytosis with Trichophyton mentagrophytes and lesions were treated with two concentrations of apigenin ointment, 2.5 mg/g, and 5mg/g. Apigenin exhibited a similar effect as the reference drug Terbinafine [ 125]. Applied at 5 mg/g for both apigenin and Terbinafine, complete recovery from the infection was recorded on the 12th day in both groups. With 2.5 mg/g ointment, the infection was cured on the 16th day [ 125]. A recent paper reported that apigenin induced cell shrinkage in C. albicans, altering the cell membrane potential and causing leakage of intracellular components [ 126]. 8.4. Antiparasitic Activity Borges G, Fong RY, Ensunsa JL, Kimball J, Medici V, Ottaviani JI, Crozier A Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. Free Radic Biol Med. (2022-May-20) Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L Polyphenols: food sources and bioavailability Am J Clin Nutr. (2004 May)

This review will explore what Apigenin is and how it works, assess its benefits in an Apigenin review, and will conclude with an FAQ section. Table of contents Mak P, Leung YK, Tang WY, Harwood C, Ho SM Apigenin suppresses cancer cell growth through ERbeta. Neoplasia. (2006-Nov) Become a savvy supplement shopper. Learn how to spot the hidden signs of low-quality products and save money by avoiding ineffective supplements. Rahmati M, Ghannadian SM, Kasiri N, Ahmadi L, Motedayyen H, Shaygannejad V, Pourazar A, Alsahebfosoul F, Ganjalikhani Hakemi M, Eskandari N Modulation of Th17 Proliferation and IL-17A Gene Expression by Acetylated Form of Apigenin in Patients with Multiple Sclerosis. Immunol Invest. (2021-Feb)It is worth mentioning again that apigenin exists in plants as glycosides naturally; therefore, the absorption of the apigenin glycosides and the bioavailability after consumption of glycosides are useful information. Nevertheless, such information on apigenin glycosides is rare, and most research done looked into other flavonoids, in particular quercetin [ 66, 67]. In fact, in comparison to the other classes of flavonoids, little is known about the bioavailability of flavones [ 68]. Some, not all, commensal gut bacteria are capable of degrading apigenin on their own. Bacteroides distasonis was found to be capable of converting apigenin-7- O-glucoside to apigenin; however, it was not the case with E. coli [ 129]. Eubacterium ramulus, a strictly anaerobic human gut bacterium, is able to metabolize apigenin, as well as quercetin, naringenin, daidzein and genistein [ 130]. It possesses a phloretin-hydrolase able to break the phloretine C-C bond [ 131]. Another anaerobic bacterium isolated from human feces, Clostridium orbiscindens, was found to degrade apigenin to 3-(4-hydroxyphenyl)propionic acid with phloretin and naringenin as the two intermediates [ 132]. This degradation product 3-(4-hydroxyphenyl)propionic acid, also known as desaminotyrosine (DAT) is beneficial during influenza by triggering type I interferon signaling and in turn augmenting antiviral responses by phagocytic cells; therefore preventing inflammation and severe disease [ 133]. It is possible that the anti-inflammatory activity and protective effects on lung tissues mentioned in the previous sections are mediated by microbial metabolites from apigenin as well [ 93, 108]. Degradation of apigenin and its glycosides most likely involves multiple bacteria, with complementary and overlapping functionalities. In a clinical trial on 87 people who underwent the surgical removal of colon tumors or polyps, a flavonoid mixture with 20 mg apigenin and 20 mg epigallocatechin gallate was associated with a lower development of colorectal tumors [ 21]. Apigenin can improve your cardiovascular health by reducing inflammation and blood pressure, which are two of the most significant risk factors regarding heart health. This benefit was shown in a study conducted on rats. This study has shown Apigenin to have cardioprotective effects in heart damaged rats. The researchers suggest that this is due to Apigenin's ability to suppress myocardial apoptosis (heart cell death) and inflammation by decreasing the activity of a major inflammatory pathway ( 15). What is the recommended Apigenin dosage?