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Opium was for many centuries the principal painkiller known to medicine and was used in various forms and under various names. Laudanum, for example, was an alcoholic tincture (dilute solution) of opium that was used in European medical practice as an analgesic and sedative. Physicians relied on paregoric, a camphorated solution of opium, to treat diarrhea by relaxing the gastrointestinal tract. The narcotic effects of opium are mainly attributable to morphine, which was first isolated about 1804. In 1898 it was discovered that treating morphine with acetic anhydride yields heroin, which is four to eight times as potent as morphine in both its pain-killing properties and its addictive potential. The other alkaloids naturally present in opium are much weaker; codeine, for example, is only one-sixth as potent as morphine and is used mainly for cough relief. Since the late 1930s, various synthetic drugs have been developed that possess the analgesic properties of morphine and heroin. These drugs, which include meperidine (Demerol), methadone, levorphonal, and many others, are known as synthetic opioids. They have largely replaced morphine and heroin in the treatment of severe pain.
Carstairs C. (2006). "Jailed for Possession: Illegal Drug Use, Regulation, and Power in Canada, 1920–61". Archived from the original on January 25, 2003. Petr Parfenovich Vladimirov (1975). The Vladimirov diaries: Yenan, China, 1942–1945. Doubleday. ISBN 978-0-385-00928-7. Protocol for Limiting and Regulating the Cultivation of the Poppy Plant, the Production of, International and Wholesale Trade in, and Use of Opium Legal opium production is allowed under the United Nations Single Convention on Narcotic Drugs and other international drug treaties, subject to strict supervision by the law enforcement agencies of individual countries. The leading legal production method is the Robertson- Gregory process, whereby the entire poppy, excluding roots and leaves, is mashed and stewed in dilute acid solutions. The alkaloids are then recovered via acid-base extraction and purified. The exact date of its discovery is unknown, but it was described by Wurtz in his Dictionnaire de chimie pure et appliquée published in 1868. [138]In June 2007, the council launched a "Poppy for Medicines" project that provides a technical blueprint for the implementation of an integrated control system within Afghan village-based poppy for medicine projects: the idea promotes the economic diversification by redirecting proceeds from the legal cultivation of poppy and production of poppy-based medicines. [143] There has been criticism of the Senlis report findings by Macfarlan Smith, who argue that though they produce morphine in Europe, they were never asked to contribute to the report. [144] Cultivation in the UK [ edit ] Max Chamka; Translated by Geraldine Ring. "3 grams of opium for 1 dollar". Caucaz europenews . Retrieved May 6, 2007.
S. Mercadante (1998). "Oral morphine consumption in Italy and Sicily". Journal of Pain and Symptom Management. 15 (4): 227–30. doi: 10.1016/S0885-3924(98)00368-6. PMID 9601157. The Greek gods Hypnos (Sleep), Nyx (Night), and Thanatos (Death) were depicted wreathed in poppies or holding them. Poppies also frequently adorned statues of Apollo, Asclepius, Pluto, Demeter, Aphrodite, Kybele and Isis, symbolizing nocturnal oblivion. [1] Islamic societies (500–1500 CE) [ edit ] Opium users in Java during the Dutch colonial period, c. 1870
Manuscripts of Pseudo-Apuleius's 5th-century work from the 10th and 11th centuries refer to the use of wild poppy Papaver agreste or Papaver rhoeas (identified as P. silvaticum) instead of P. somniferum for inducing sleep and relieving pain. [27]
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