Janeway's Immunobiology

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T cells also originate in the bone marrow, but all the important events in their development occur in the thymus Mucosa-associated lymphoid tissue is located in anatomically defined microcompartments throughout the gut

Transport proteins that bind to the Fc regions of antibodies carry particular isotypes across epithelial barriers This activity was later determined to be due to the proteins we now call antibodies, which bind specifically to the toxins and neutralize their activity. B cells develop in the bone marrow with the help of stromal cells and achieve maturity in peripheral lymphoid organsThe DNA sequence encoding a complete V region is generated by the somatic recombination of separate gene segments The terminal complement proteins polymerize to form pores in membranes that can kill certain pathogens Natural killer cells are activated by interferons and macrophage-derived cytokines to serve as an early defense against certain intracellular infections Susceptibility to autoimmune disease is controlled by environmental and genetic factors, especially MHC genes Immunobiology is the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope. Every chapter is reviewed with experts to ensure accuracy, authority, currency, and depth. The Tenth Edition is supported by InQuizitive, Norton’s award-winning, easy-to-use adaptive learning tool that helps students learn immunological terms and apply them conceptually. Table of Contents:

Activated T cells synthesize the T-cell growth factor interleukin-2 and its receptor. & 8-10 The co-stimulatory signal is necessary for the synthesis and secretion of IL-2 The differentiation of CD4 T cells into T H 1 or T H 2 cells determines whether humoral or cell-mediated immunity will The invariant chain directs newly synthesized MHC class II molecules to acidified intracellular vesicles Jenner’s strategy of vaccination was extended in the late 19th century by the discoveries of many great microbiologists. Rearrangement of the β-chain locus and production of a β chain trigger several events in developing thymocytesActivation of specialized antigen-presenting cells is a necessary first step for induction of adaptive immunity Autoantibodies against extracellular antigens cause inflammatory injury by mechanisms akin to type II and type III hypersensitivity reactions Some pathogens resist destruction by host defense mechanisms or exploit them for their own purposes Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001.

The variable chains of lymphocyte antigen receptors are associated with invariant accessory chains that carry out the signaling function of the receptor

Contents

Transmembrane and secreted forms of immunoglobulin are generated from alternative heavy-chain transcripts The Fc receptors of accessory cells are signaling receptors specific for immunoglobulins of different isotypes The normal pathways for host defense against intracellular bacteria are illustrated by genetic deficiencies of IFN-γ and IL-12 and their receptors Most IgE is cell-bound and engages effector mechanisms of the immune system by different pathways from other antibody isotypes

The 9th edition also includes updates on recent developments in multiple immunology subfields. Notably, the section on innate immunity has added a discussion of immune effector modules, which are critical to understanding the pathogenesis of inflammatory bowel disease, intestinal infection, and several other diseases. The section on therapeutics now contains a discussion of chimeric antigen receptors, an active and important area of cancer immunotherapy research. A particularly significant feature of this edition is an overhaul of the end-of-chapter questions and the addition of an instructors’ question bank. The 9th edition replaces the handful of often open-ended review questions at the end of each chapter with multiple-choice and true-false questions, providing an easier avenue for instructors to test the material. Cyclosporin A, FK506 (tacrolimus), and rapamycin (sirolimus) are powerful immunosuppressive agents that interfere with T-cell signalingThe second phase of the primary B-cell immune response occurs when activated B cells migrate to follicles and proliferate to form germinal centers Lymphocytes activated by antigen give rise to clones of antigen-specific cells that mediate adaptive immunity