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PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

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P.P. Ruvolo, “Galectin-3 as a Guardian of the Tumor Microenvironment,” Biochim. Biophys. Acta. 1863(3), 427–437 (2016).

There were also no negative side effects observed in a clinical trial involving children with lead toxicity in China. For three months, the hospitalized children between the ages of 5 and 12 were given 15 g of MCP in three divided doses a day [ 4]. Pound C., Partin A., Eisenberger M., Chan D.W., Pearson J.D., Walsh P.C. Natural history of progression after PSA elevation following radical prostatectomy. JAMA. 1999;281:1591–1597. doi: 10.1001/jama.281.17.1591.

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The field of Gal-3 continues to expand to previously undocumented conditions, as shown recently with findings in sepsis, mental illness, brain injury and others. Concurrently, we can expect the therapeutic significance of the correct form of MCP — the only commercially available natural Gal-3 inhibitor — to likewise increase, making it perhaps the most important ingredient available to support and maintain long-term health and wellness. Z.Y. Zhao, et al., “The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized with Toxic Lead Levels,” Altern. Ther. Health Med. 14(4), 34–38 (2008). These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Modified citrus pectin has also shown promise in oncology. Studies have found that this dietary supplement may stop cancer cells from spreading [ 8, 9]. It keeps the proliferation of cancer cells down both in vitro (test tube) and in vivo (within the living). This is thought to be due to MCP’s ability to cause apoptosis (cell death) in these tumor cells.

Azémar M, Hildenbrand B, Haering B, Heim ME, Unger C. Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study. Clin Med Oncol. 2007 Jan;1:CMO.S285. DOI: 10.4137/CMO.S285. Extracellular GAL1 and GAL3 directly modulate tumour cell fitness, migration, EMT and stemness through their interactions with glycosylated tumour-associated receptors, including epidermal growth factor (EGF), transforming growth factor β (TGFβ) receptors and cell surface integrins 68, 69, 70, 71, 72, 73, 74, that contribute to cancer progression and metastasis. GAL1 can trigger EMT in gastric cancer 75 and hepatocellular carcinoma 72, 76 via non-canonical activation of the Hedgehog pathway 75, downregulation of E-cadherins 72 and induction of α vβ 3 integrin-dependent AKT signalling 76. Collectively, these actions have an impact on clinical outcomes and therapeutic responses to both sorafenib and doxorubicin 77, 78. GAL1 also regulates events that promote the growth of pancreatic adenocarcinoma, including tumour cell proliferation, invasion and metastasis 78, and GAL1 silencing inhibits migration and invasion of metastatic castration-resistant prostate cancer cells via suppression of androgen receptor and AKT-mediated signalling 79. In turn, interactions between GAL3 and the glycosylated transmembrane protein mucin 1 (MUC1) enhance EGF receptor dimerization and activation (Fig. 2), and thus promote proliferation and motility of epithelial cancer cells by activating ERK1/2 and AKT signalling pathways 80, 81. Notably, complex N-glycans linked to EGF receptors on breast carcinoma cells control EMT, cell motility and tumour metastasis by facilitating the exposure of GAL3-specific glycoepitopes 68 (Fig. 2). Tumour-derived GAL3 also promotes invasion via its capacity to impair interactions between adhesion molecules expressed on the surface of malignant cells and N-glycosylated proteins within the extracellular matrix, such as laminin and fibronectin 74. Furthermore, GAL3 promotes the establishment of metastatic niches by binding to the Thomsen–Friedenreich antigen (Tf antigen) expressed by metastatic lung tumour cells 70 and facilitating homotypic and heterotypic aggregation and emboli formation 82. Similarly, overexpression of GAL3 promotes proliferation, migration and invasion of oral squamous cell carcinoma (OSCC) cells via enhanced WNT–β-catenin signalling and EMT 83. The interaction of GAL3 with α vβ 3 integrin promotes KRAS addiction 84; these findings identified GAL3 as a potential druggable target for ‘KRAS-addicted’ lung and pancreatic cancers (Fig. 2). PectaSol-C Modified Citrus Pectin, Potassium, Sodium, Dietary Fiber, Vegetable capsule (natural vegetable cellulose, water), stearic acid, magnesium stearate, microcrystalline cellulose, silicon dioxide.To overcome this limitation, control its renal clearance and improve its therapeutic efficacy, G3-C12 ( 27, Fig. 5) was conjugated to an N-(2-hydroxypropyl)methacrylamide polymeric carrier. This substitution increased its molecular size and generated a larger GAL3-targeted copolymer that was proposed as an anticancer agent 260, 261. Conjugation of HMPA–G3-C12 copolymer to 5-FU led to increased cytotoxicity, tumour cell apoptosis and inhibition of migration in vitro compared with 5-FU, as well as greater reductions in tumour volume in a PC-3 prostate cancer mouse model 262. Micellar nanoparticles assembled by poly(oligo(ethylene glycol)) monomethyl ether methacrylate (POEGMA) and poly(ε-caprolactone) (PCL) copolymers conjugated to G3-C12 peptide were designed to deliver G3-C12 ( 27, Fig. 5) to the tumour microenvironment. This copolymer formed nanoparticles that were loaded with the anticancer drug bufalin (BUF) and tested as a drug delivery system for castration-resistant prostate cancer (CRPC). Biodegradable BUF-G3-C12 nanoparticles exhibited controlled drug release and enhanced tumour reduction in mice bearing DU145 prostate cancer cells 263. Biological agents If you’re concerned about possible sensitivities to MCP, consult with your practitioner before use, and start with a lower dose to see how your body responds. The Bottom Line on Modified Citrus Pectin PectaSol® Metal Detox exerts a dual action in the body. Algimate® Modified Alginate Complex remains in the digestive tract where it works to bind and eliminate heavy metals and radioactive particles to be eliminated through the stools. PectaSol-C® MCP is absorbed into the circulation from the intestine and works systemically, binding heavy metals and environmental pollutants in the circulation for safe elimination through the urinary system.* J.R. Sádaba, et al., “Role for Galectin-3 in Calcific Aortic Valve Stenosis,” J. Am. Heart Assoc. 5(11), pii: e004360 (2016). Suggested Use:As a dietary supplement, for maximum support, take one 5 gram scoop 3 times daily with liquid on any empty stomach. For long term maintenance, take one 5 gram scoop daily with liquid on an empty stomach.

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