Lucozade Sport Orange 12x500ml (Packaging May Vary)

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Chandrasekaran, S., Rochtchina, E., and Mitchell, P. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma. 2005;14(6):504-507. View abstract. One study investigated how the timing of caffeine ingestion affects sleep. Researchers gave 12 healthy adults 400 mg of caffeine either six hours before bedtime, three hours before bedtime or immediately prior to bedtime.

Firestone, P., Davey, J., Goodman, J. T., and Peters, S. The effects of caffeine and methylphenidate on hyperactive children. J.Am.Acad.Child Psychiatry 1978;17(3):445-456. View abstract. Chroscinska-Krawczyk, M., Ratnaraj, N., Patsalos, P. N., and Czuczwar, S. J. Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures. Pharmacol Rep. 2009;61(5):819-826. View abstract.

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Given this effect, it’s not surprising that large doses of caffeine may lead to loose stools or even diarrhea in some people. Chen, J. F. and Chern, Y. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Handb.Exp.Pharmacol 2011;(200):267-310. View abstract.

Astorino, T. A., Terzi, M. N., Roberson, D. W., and Burnett, T. R. Effect of caffeine intake on pain perception during high-intensity exercise. Int.J Sport Nutr.Exerc.Metab 2011;21(1):27-32. View abstract.Arendash, G. W. and Cao, C. Caffeine and coffee as therapeutics against Alzheimer's disease. J Alzheimers.Dis. 2010;20 Suppl 1:S117-S126. View abstract.