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Caffeine, as do other alkaloids such as cinchonine, quinine or strychnine, precipitates polyphenols and tannins. This property can be used in a quantitation method. [ clarification needed] [213] Natural occurrence Roasted coffee beans This section needs expansionwith: practical management of overdose, see PMID 30893206. You can help by adding to it. ( November 2019) Smith A (September 2002). "Effects of caffeine on human behavior". Food and Chemical Toxicology. 40 (9): 1243–55. doi: 10.1016/S0278-6915(02)00096-0. PMID 12204388.
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Kugelman A, Durand M (December 2011). "A comprehensive approach to the prevention of bronchopulmonary dysplasia". Pediatric Pulmonology. 46 (12): 1153–65. doi: 10.1002/ppul.21508. PMID 21815280. S2CID 28339831. O'Connor A (4 March 2008). "Really? The claim: caffeine causes dehydration". New York Times. Archived from the original on 3 September 2011 . Retrieved 3 August 2009.
Wang L, Shen X, Wu Y, Zhang D (March 2016). "Coffee and caffeine consumption and depression: A meta-analysis of observational studies". The Australian and New Zealand Journal of Psychiatry. 50 (3): 228–42. doi: 10.1177/0004867415603131. PMID 26339067. S2CID 23377304. Amphetamines increase dopamine/norepinephrine release and inhibit their reuptake, leading to central nervous system (CNS) stimulation Bishop D (December 2010). "Dietary supplements and team-sport performance". Sports Medicine. 40 (12): 995–1017. doi: 10.2165/11536870-000000000-00000. PMID 21058748. S2CID 1884713. Tarnopolsky MA (2010). "Caffeine and creatine use in sport". Annals of Nutrition & Metabolism. 57 (Suppl 2): 1–8. doi: 10.1159/000322696. PMID 21346331. Global coffee consumption, 2020/21". Statista. Archived from the original on 3 March 2021 . Retrieved 10 March 2021.
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Liu R, Guo X, Park Y, Huang X, Sinha R, Freedman ND, etal. (June 2012). "Caffeine intake, smoking, and risk of Parkinson disease in men and women". American Journal of Epidemiology. 175 (11): 1200–7. doi: 10.1093/aje/kwr451. PMC 3370885. PMID 22505763. The differing perceptions in the effects of ingesting beverages made from various plants containing caffeine could be explained by the fact that these beverages also contain varying mixtures of other methylxanthine alkaloids, including the cardiac stimulants theophylline and theobromine, and polyphenols that can form insoluble complexes with caffeine. [219] Products Caffeine content in select food and drugs [220] [221] [222] [223] [224] According to Chinese legend, the Chinese emperor Shennong, reputed to have reigned in about 3000 BCE, inadvertently discovered tea when he noted that when certain leaves fell into boiling water, a fragrant and restorative drink resulted. [247] Shennong is also mentioned in Lu Yu's Cha Jing, a famous early work on the subject of tea. [248]The biosynthesis of caffeine is an example of convergent evolution among different species. [202] [203] [204] a b c Liguori A, Robinson JH (July 2001). "Caffeine antagonism of alcohol-induced driving impairment". Drug and Alcohol Dependence. 63 (2): 123–9 Tea contains more caffeine than coffee by dry weight. A typical serving, however, contains much less, since less of the product is used as compared to an equivalent serving of coffee. Also contributing to caffeine content are growing conditions, processing techniques, and other variables. Thus, teas contain varying amounts of caffeine. [231] A systematic review and meta-analysis from 2014 found that concurrent caffeine and L-theanine use has synergistic psychoactive effects that promote alertness, attention, and task switching; [57] these effects are most pronounced during the first hour post-dose. [57] Physical performance
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Yang TW, Wang CC, Sung WW, Ting WC, Lin CC, Tsai MC (March 2022). "The effect of coffee/caffeine on postoperative ileus following elective colorectal surgery: a meta-analysis of randomized controlled trials". International Journal of Colorectal Disease. 37 (3): 623–630. doi: 10.1007/s00384-021-04086-3. PMC 8885519. PMID 34993568. S2CID 245773922. The addition of caffeine (100–130mg) to commonly prescribed pain relievers such as paracetamol or ibuprofen modestly improves the proportion of people who achieve pain relief. [47]
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Brent RL, Christian MS, Diener RM (April 2011). "Evaluation of the reproductive and developmental risks of caffeine". Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92 (2): 152–87. doi: 10.1002/bdrb.20288. PMC 3121964. PMID 21370398. O'Callaghan F, Muurlink O, Reid N (7 December 2018). "Effects of caffeine on sleep quality and daytime functioning". Risk Management and Healthcare Policy. 11: 263–271. doi: 10.2147/RMHP.S156404. PMC 6292246. PMID 30573997.