Nuromol Pain Relief Tablets, Paracetamol and Ibuprofen, Pack Of 16, From The Makers Of Nurofen

Product Information

Ibuprofen is an NSAID that has demonstrated its efficacy in the common animal experimental inflammation models by inhibition of prostaglandin synthesis. Prostaglandins sensitise nociceptive afferent nerve terminals to mediators such as bradykinin. Ibuprofen therefore elicits an analgesic effect through peripheral inhibition of the cycloxygenase-2 (COX-2) isoenzyme with a subsequent reduction in sensitisation of nociceptive nerve terminals. Ibuprofen has also been shown to inhibit induced-leucocyte migration into inflamed areas. Ibuprofen has a pronounced action within the spinal cord due, in part, to the inhibition of COX. Ibuprofen's antipyretic effects are produced by the central inhibition of prostaglandins in the hypothalamus. Ibuprofen reversibly inhibits platelet aggregation. In humans, ibuprofen reduces inflammatory pain, swellings and fever. Take 1 tablet to be taken with water and food , up to three times a day. Leave at least 6 hours between doses. Nurofen Joint & Muscular Pain Relief 200mg Medicated Plaster, For pain relief of muscular strains or sprains close to the joint of the upper or lower limb. Contain ibuprofen. If you operate machinery or are considering driving whilst using this medication, you may be asking “Does Nuromol make you sleepy?” If you're taking alendronic acid it's best to avoid taking Nuromol unless it's been recommended by your doctor, because ibuprofen may increase the risk of irritation to the foodpipe, stomach or intestines.

NUROMOL DUAL ACTION 200 MG 500 MG FILM-COATED TABLETS NUROMOL DUAL ACTION 200 MG 500 MG FILM-COATED TABLETS

When GI bleeding or ulceration occurs in patients receiving ibuprofen containing products, the treatment should be withdrawn.

This product (like any other ibuprofen containing products and NSAIDs) should be used with caution in combination with: Alanine aminotransferase increased, gamma-glutamyltransferase increased and liver function tests abnormal with paracetamol. If one tablet doesn’t control symptoms, then a maximum of 2 tablets may be taken up to 3 times a day. Do not take more than 6 Nuromol UK tablets in any 24 hour period. Nuromol And Panadol Ibuprofen belongs to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing pain, reducing swelling and lowering high temperatures. A randomised, double-blind placebo-controlled studies were conducted with the combination using the acute pain model of post-operative dental pain. The studies show that:

Nuromol Dual Action Pain Relief 200mg/500mg tablets 6s

A randomised, double-blind controlled clinical study was conducted with the product in the treatment of chronic knee pain. The study showed that: The product provides more effective pain relief than paracetamol 1000 mg in short-term treatment (p<0.01) and long term treatment (p<0.01). During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to: Antihypertensives (ACE inhibitors and Angiotensin II Antagonists) and diuretics: NSAIDs may reduce the effects of these drugs. In some patients with compromised renal function (e.g. dehydrated patients or elderly patients with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible. These interactions should be considered in patients taking a coxib concomitantly with ACE inhibitors or angiotensin II antagonists. Therefore, the combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter. Diuretics may increase the risk of nephrotoxicity of NSAIDs. If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacistOnly use the minimum effective dose for the shortest time necessary to relieve your symptoms. You should not take Nuromol 200mg/500mg tablets for longer than 3 days. If your symptoms worsen or persist, consult your doctor. The lowest effective dose should be used for the shortest duration necessary to relieve symptoms (see section 4.4). Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels. Evidence has shown that in acute pain states, paracetamol/ibuprofen medicinal combinations such as a Nuromol Tablet can frequently offer better pain relief than either of the ingredients alone. This product (like any other ibuprofen containing products and NSAIDs) is contraindicated in combination with:

Nuromol Dual Action Pain Relief 200mg/500mg tablets 6s Nuromol Dual Action Pain Relief 200mg/500mg tablets 6s

Patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be managed in accordance with established guidelines. Paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). Ibuprofen also brings down a fever by reducing the production of prostaglandins in the brain. How do I take Nuromol? The serum half-life of ibuprofen is 1.2-2 hours. In patients with a compromised liver function, the half-life can be prolonged to 3.1-3.4 hours. A minor hydroxylated metabolite, which is usually produced in very small amounts by mixed function oxidases in the liver and detoxified by conjugation with liver glutathione, may accumulate following paracetamol overdose and cause liver damage. studies suggest that use of ibuprofen particularly at high a dose (2400 mg/day) may be associated with a small increased risk of arterial thrombotic events (for example myocardial infarction or stroke) (see section 4.4).As said above, overdosing is a really possibility and can lead to many serious side effects, including fatality. A pharmacist will be able to explain why taking medications such as Nuromol and Panadol together is a bad idea. This product is especially suitable for pain which requires stronger pain relief than ibuprofen 400 mg or paracetamol 1000 mg alone, and faster pain relief than ibuprofen. Paracetamol IV is used for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, the reduction of fever.

NUROMOL DUAL ACTION 200 MG 500 MG FILM-COATED TABLETS

Acid Reflux Heartburn is a burning feeling in the chest caused by stomach acid travelling up towards the throat (acid reflux). If it keeps happening, it’s called gastro-oesophageal reflux disease (GORD). Do not take more than six tablets in any 24 hour period (equivalent to 3000mg paracetamol, 1200mg ibuprofen a day). Bullous reactions including Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis 2. Exfoliative dermatoses, purpura, photosensitivityParacetamol is a non-salicylate antipyretic and non-opioid analgesic agent. Paracetamol IV injection is a sterile, clear, colorless, non pyrogenic, isotonic formulation of Paracetamol intended for intravenous infusion. Prolonged use at higher than recommended doses may result in severe hypokalaemia and renal tubular acidosis. Symptoms may include reduced level of consciousness and generalised weakness (see section 4.4 and section 4.8). Adults aged 18 years and over can take one Nuromol tablet with water up to three times a day. Leave at least six hours between doses. Women who are pregnant. Ibuprofen may increase the risk of miscarriage and malformations and should not be used during the first and second trimesters of pregnancy unless considered essential by your doctor. Ibuprofen must not be taken in the third trimester because it may delay labour, increase the length of labour and cause complications in the newborn baby.