Molecule by Pud&Mun 01 Perfume- Iso E Super (100ml)

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Iso E Super may cause allergic reactions detectable by patch tests in humans [8] and chronic exposure to Iso E Super from perfumes may result in permanent hypersensitivity. In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but negative in the mouse ear swelling test (MEST). [9] Iso E Super is a molecule that hovers close to the skin to create an indefinable aura around the wearer. Belsito; etal. (2013). "A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. RIFM Expert Panel". Food and Chemical Toxicology. 62: S1-44. doi: 10.1016/j.fct.2013.09.033. PMID 24246175. The biodegradation of OTNE in fresh water (T1/2) is at most 40 days, and at most 120 days in sediment (OECD 314 test), though the biodegradation within the 28day window was around 11% (OECD 301-C). Given the outcome of the OECD 314 test OTNE does not meet the criteria for “Persistent” (P) or “very Persistent” (vP).

The International Fragrance Association (IFRA) has published safe use levels for Iso E Super in consumer products. [10] Several health related studies have been conducted on OTNE, and based on these studies, OTNE has been determined to be safe under the current conditions of use. [12] [13] Our Molecule Scent 01 contains a proprietary mixture of Iso E Super, that focuses on gamma isomers, which results in increased allure. standards library - IFRA International Fragrance Association - in every sense". www.ifraorg.org. Archived from the original on 2015-02-25.

a b US 3929677,Hall, John B.&Sanders, James Milton,"Perfume composition and perfume articles containing one isomer of an octahydrotetramethyl acetonaphthone",issued 1975 Discover the captivating nature of Iso E Super, an aroma-chemical that transcends traditional fragrances. Experience the allure of its sweet cedarwood-like scent and embrace the intrigue it brings to both the wearer and those around them. Bester, K. (Nov 2008). "Surface water concentrations of the fragrance compound OTNE in Germany--a comparison between data from measurements and models". Chemosphere. 73 (8): 1366–72. Bibcode: 2008Chmsp..73.1366B. doi: 10.1016/j.chemosphere.2008.06.057. PMID 18715610.

Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) M990091". OTNE is the abbreviation for the fragrance material with Chemical Abstract Service ( CAS) numbers 68155-66-8, 54464-57-2 and 68155-67-9 and EC List number 915-730-3. It is a multi-constituent isomer mixture containing: Tetramethyl acetyloctahydronaphthalenes (International Nomenclature for Cosmetic Ingredients ( INCI) name) (1-(1,2,3,4,5,6,7,8-ottaidro-2,3,8,8,-tetrametil-2-naftil)etan-1-one) is a synthetic ketone fragrance also known as OTNE (octahydrotetramethyl acetophenone) and by other commercial trade names such as: Iso E Super, Iso Gamma Super, Anthamber, Amber Fleur, Boisvelone, Iso Ambois, Amberlan, Iso Velvetone, Orbitone, Amberonne. It is a synthetic woody odorant and is used as a fragrance ingredient in perfumes, laundry products and cosmetics. [1] Odour [ edit ]Fahlbusch, Karl-Georg; etal. (2007), "Flavors and Fragrances", Ullmann's Encyclopedia of Industrial Chemistry (7thed.), Wiley, pp.45–46 Iso E Super has a marked intermittence. To the wearer, it seems to vanish and then re-appear. This is due to the way it bonds with receptors in the olfactory system, only slowly releasing to make way for a fresh charge of the molecule on the receptors. Scientific Committee on Consumer Safety (2011). "Annex I: Clinical evidence regarding sensitisation to individual fragrance chemicals and to natural extracts" (PDF). SCCS Opinion on fragrance allergens in cosmetics. European Union. p.63. SCCS/1459/11. The fragrance Molecule 01 (Escentric Molecules, 2005) is a specific isomer of Iso E Super, by the company IFF. [19] Its partner fragrance Escentric 01 contains Iso E Super along with ambroxan, pink pepper, green lime with balsamic notes like benzoin mastic and incense.