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Overall, the available evidence indicates that probiotics might reduce some symptoms of IBS. However additional high-quality clinical trials are needed to confirm the specific strain, dose, and duration of treatment required as well as the type of IBS (such as with predominant diarrhea or constipation) that can be treated effectively with probiotics. Hypercholesterolemia With clinically-researched live bacteria, combined with specifically-selected nutrients, ProVen products are designed for all lifestages and individual needs.
A Healthy Gut for a Healthy Life Concentrated - Probiotics
Another meta-analysis included eight randomized clinical trials with a total of 741 participants from birth to 36 months of age who were treated with Lactobacillus or Bifidobacterium for 4 to 24 weeks. The results also suggested that probiotics containing Lactobacillus might reduce atopic dermatitis symptoms in infants and toddlers, but those containing Bifidobacterium did not [ 16]. The treatment significantly improved symptoms in participants with moderate-to-severe forms of the disease but not in those with mild forms. A Cochrane Review of 39 RCTs of single probiotics and probiotic mixtures for the treatment of eczema in 2,599 participants age 1 to 55 years (most were children) found that probiotic treatment might slightly reduce SCORAD scores. However, the researchers concluded that the differences were not clinically significant and that the current evidence does not support the use of probiotics for eczema treatment [ 17]. Ghouri YA, Richards DM, Rahimi EF, Krill JT, Jelinek KA DuPont AW. Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease. Clin Exp Gastroenterol 2014; 7: 473-87. [ PubMed abstract] Several meta-analyses have assessed the role of probiotics in patients with IBS [ 42-46]. Most have found that probiotics have a positive, although modest, beneficial effect. For example, a meta-analysis of 23 RCTs in a total of 2,575 patients found that, overall, probiotics reduced the risk that IBS symptoms would persist or not improve by 21% [ 42]. Various species and strains of probiotics had beneficial effects on global IBS symptoms, abdominal pain, bloating, and flatulence scores, but the quality of the studies was low. Some combinations of probiotics were superior to individual strains in this analysis, but no specific combination was superior to another. A second meta-analysis of 15 RCTs in a total of 1,793 patients with IBS found that probiotics reduced overall symptoms and abdominal pain more than placebo after 8 to 10 weeks of therapy; in children, these supplements also improved mucosal barrier function [ 43]. International Scientific Association for Probiotics and Prebiotics. Deciphering a probiotic label . 2017. To help with this, we have developed a number of products specifically for children, that include our ProVen friendly bacteria with vitamins to support immunity.
Borriello SP, Hammes WP, Holzapfel W, Marteau P, Schrezenmeir J, Vaara M, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. [ PubMed abstract] The International Scientific Association for Probiotics and Prebiotics advises manufacturers to list the total number of CFUs—ideally for each strain—on the expiration or use by date on the product label [ 74]. The association also suggests that consumers of these supplements avoid products that list the number of CFUs at time of manufacture because this information does not account for declines in CFUs over a product’s lifespan. References Kaur L, Gordon M, Baines PA, Iheozor-Ejiofor Z, Sinopoulou V Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2020; 3: Cd005573. [ PubMed abstract] Borgeraas H, Johnson LK, Skattebu J, Hertel JK, Hjelmesaeth J. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 2018;19:219-32. [ PubMed abstract] Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9. [ PubMed abstract]
Probiotics - Health Professional Fact Sheet Probiotics - Health Professional Fact Sheet
Subgroup analyses showed that the use of probiotics during both the prenatal and postnatal periods significantly reduced the incidence of dermatitis; however, probiotics taken either prenatally only or postnatally only did not. In addition, the effects of probiotic treatment varied by probiotic strain. For example, supplementation with either Lactobacillus rhamnosus or Lactobacillus paracasei significantly reduced the incidence of atopic dermatitis, whereas supplementation with Lactobacillus reuteri or Lactobacillus acidophilus did not.Not all friendly bacteria are equal. When choosing your friendly bacteria supplement, always look for the following 12 criteria as a start point and then select the best product(s) to suit you and your family. Derikx LA, Dieleman LA Hoentjen F. Probiotics and prebiotics in ulcerative colitis. Best Pract Res Clin Gastroenterol 2016; 30: 55-71. [ PubMed abstract]
Probiotics for Kids - ProVen Probiotics | Life Concentrated Probiotics for Kids - ProVen Probiotics | Life Concentrated
Production by lactobacilli and bifidobacteria of short-chain fatty acids, which lower hepatic cholesterol synthesis and regulate cholesterol metabolism [ 50-53] Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts. For these reasons, the common probiotic species—such as Lactobacillus species ( acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius) and Bifidobacterium species ( adolescentis, animalis, bifidum, breve, and longum)—are unlikely to cause harm [ 3]. Jafarnejad S, Shab-Bidar S, Speakman JR, Parastui K, Daneshi-Maskooni M, Djafarian K. Probiotics reduce the risk of antibiotic-associated diarrhea in adults (18-64 years) but not the elderly (>65 years): a meta-analysis. Nutr Clin Pract 2016;31:502-13. [ PubMed abstract] In contrast, the most recent systematic review and meta-analysis, which included 19 randomized trials in 1,412 participants, found that supplementation with probiotics or synbiotics reduced waist circumference slightly (by 0.82 cm) but had no effect on body weight or body mass index, although the quality of evidence was low to moderate [ 63]. The findings from another meta-analysis of 14 trials in 881 adults, 5 trials in 726 children, and 12 trials in 1,154 infants suggested that probiotics promote loss of a mean of 0.54 kg in adults, gain of a mean of 0.20 kg in children, and no significant weight loss or gain in infants [ 64].Researchers have studied the use of probiotics to improve lipid profiles. The mechanisms of their effects on cholesterol concentrations include catabolism of cholesterol by increasing:
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Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C. A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr 2019;73:24-37. [ PubMed abstract] Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol 2015;21:3072-84. [ PubMed abstract]Hogan DE, Ivanina EA, Robbins DH. Probiotics: a review for clinical use. Gastroenterology & Endoscopy News 2018:1-7. Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] ProVen Probiotics Adult Acidophilus & Bifidus – 50 Billion is an ultra-high-strength friendly bacteria supplement for use alongside antibiotics for adults aged 16+. Each capsule contains 50 billion friendly bacteria and should be taken both alongside and following a course of antibiotics, allowing at least two hours between taking the antibiotics and taking the probiotic capsule.
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