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Kwai Blood Pressure | Tablets I Potassium to support normal blood pressure | Magnesium and Zinc contribute to normal muscle function (incl heart muscle) I Iron and Vitamins B6 & B12 improve energy levels | 30 tablets

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For the meta-analysis of the effects of garlic on blood pressure in hypertensive subjects, we included randomised double-blind placebo-controlled trials on garlic for blood pressure with a minimum of 2 months duration, identified in previous meta-analyses: Specifically, Silagy and Neil, 1994 ( 26), Reinhart et al, 2008 ( 2), Ried et al, 2008 ( 1), Rohner et al, 2014 ( 3) and Ried, 2016 ( 4). We extended the search in Medline for trials published between 1955 and December, 2018 with no language restrictions, using the search terms ‘garlic’ AND ‘blood pressure’ OR ‘hypertension’. AGE, aged garlic extract; GP, garlic powder; GP jpn, Japanese garlic powder containing egg yolk; G2, main garlic group, P, placebo group; HT, hypertensive subgroup; RG, raw garlic; mg; milligram; mg/dl, milligram per decilitre; mmHg, millimetre of mercury; NA, not applicable; NR, not reported; NZ, New Zealand; pt, potential; SAC, S-allylcysteine; SBP/DBP, systolic/diastolic blood pressure. Furthermore, previous research suggests that garlic is effective in normalising blood cholesterol levels. A meta-analysis of 39 trials and 2,300 participants demonstrated an improvement in total cholesterol and low-density-lipoprotein (LDL) in adults with slightly elevated levels at baseline ( 44). Our second dose-response trial revealed that a dose of 2 capsules/day of Kyolic aged garlic extract was sufficient to achieve an average blood pressure-lowering effect of 10 mmHg systolic and 5 mmHg diastolic, within 2–3 months ( 6). By contrast, 1 capsule per day was insufficient, whereas 4 capsules/day were not superior to 2 capsules/day. Two capsules of the High Potency Formula of Kyolic (Wagner/Nutralife available in Australia/New Zealand) contains 480 mg of concentrated aged garlic extract powder and 1.2 mg S-allyl cysteine (SAC), and are equivalent to 2 capsules of the Reserve Formula of Kyolic (Wakunaga of America available in the USA), containing 1.2 g of aged garlic extract powder and 1.2 mg of SAC.

Furthermore, as high blood pressure has been linked to the dysbiosis of gut microbiota, both in animal and human studies, with a significant lower microbial richness and diversity in hypertensive subjects compared to normotensive subjects ( 18), we investigated the effects of Kyolic garlic on the microbiome in our most recent clinical study, the GarGIC trial ( 8). In general, a higher relative abundance/bacterial mass/microbial richness and a diversity of microbial species is associated with better health ( 18– 20).In addition to the beneficial effects of garlic supplements on blood pressure, we, as well as others have found that Kyolic aged garlic extract is effective in rejuvenating the arteries, as evidenced by a reduction in pulse wave velocity ( 7, 8, 12). While arterial stiffness increases naturally with age by an average of 1.43 m/sec pulse wave velocity in 10 years ( 13, 14), our findings suggested that Kyolic aged garlic extract has the potential to reverse the ageing of the arteries and therefore, arterial stiffness by approximately 5 years, as evidenced by a mean reduction in pulse wave velocity by 0.7 m/sec within 3 months ( 8). Your doctor will carry out some blood and urine tests, and ask questions about your health to determine your risk of other problems: The medicine will not necessarily make you feel any different, but this does not mean it's not working. eat a low-fat, balanced diet – including plenty of fresh fruit and vegetables; get tips on eating more healthily Whatever your age or ability, regular exercise can have many beneficial impacts to your overall health, alongside your heart’s health. Statistics show that it can reduce your risk of major illness, heart disease, diabetes, stroke, and cancer by up to 30% 4. Try taking as little as 20 minutes per day to exercise – this could be a stroll, a run, or taking a yoga class. Whatever your exercise activity may be, it can contribute to the health of your heart.

Simple lifestyle changes can help reduce high blood pressure, although some people may need to take medicine as well.

Garlic

Your GP can advise you about changes you can make to your lifestyle and discuss whether they think you'd benefit from medicine. Get more advice about lifestyle changes to prevent and reduce high blood pressure Medicines for high blood pressure You can take these steps today, regardless of whether or not you're taking blood pressure medicines. Our meta-analyses on the effects of garlic on hypertension, including 12 trials and 553 adults with high blood pressure, suggested that garlic supplements significantly lower SBP by an average of 8.3±1.9 mmHg and DBP (n=374) by 5.5±1.9 mmHg. We included studies with adults with uncontrolled hypertension [mean ± standard deviation (SD): SBP, ≥140±2 mmHg and/or DBP, ≥90±2 mmHg], using garlic-only supplements, and reporting the mean SBP and/or DBP with SD or standard error (SE) at baseline and at end of the intervention. We included hypertensive subjects on an established plan of blood pressure medication, or subjects who were not taking any blood pressure medication at time of the trial. We excluded trials and trial arms with normotensive subjects, trials or trial arms using garlic-combination products, and trials with a very high attrition rate (loss to follow-up, >30%).

if your blood pressure is consistently above 140/90mmHg (or 135/85mmHg at home) and your risk of other problems is high – you'll be offered medicine to lower your blood pressure, in addition to lifestyle changes Not all participants of the trials included in the meta-analysis on systolic hypertension also suffered from diastolic hypertension. Eight out of the 12 trials involving 374 subjects met the inclusion criteria for the meta-analysis of diastolic hypertension ( 7, 8, 28– 30, 32, 34, 35). They used to be a popular treatment for high blood pressure, but now tend to be used only when other treatments have not worked.

When treatment is recommended

Briefly, the mechanisms of action through which garlic influences blood pressure involve two main signalling pathways via nitric oxide (NO) and hydrogen sulphide (H 2S) production ( 16). Garlic, a sulphur donor, provides an important component for the trans-sulphuration pathway, which is linked to the methylation pathway, with both requiring several co-factors, such as vitamin B12, folate, vitamin B2 and vitamin B6. In addition, known genetic variants for the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) enzymes influence the efficiency of H 2S production, and thus are considered to play an important role in the susceptibility to developing hypertension, in conjunction with deficiencies in B vitamins. We have previously identified a potentially large proportion (80%) of healthy adults in Australia with sub-optimal vitamin B12 levels (<500 pg/l) ( 17). Therefore, deficiencies in co-factors, such as vitamin B12, may explain the individual responsiveness of blood pressure to garlic observed in our clinical trials. cut your salt intake to less than 6g (0.2oz) a day, which is about a teaspoonful – find out how you can reduce the amount of salt in your diet Latest research has provided new evidence for Kyolic aged garlic extract to improve central haemodynamic measures, including central blood pressure and pulse pressure, and pulse wave velocity, a measure for arterial stiffness, regarded as important predictors for cardiovascular disease. Kyolic aged garlic extract has the potential to reverse the ageing of the arteries and therefore, arterial stiffness by approximately 5 years, as evidenced by a mean reduction in pulse wave velocity by 0.7 m/sec within 3 months.

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