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Reid, D.M.; Hosking, D.; Kendler, D.; Brandi, M.L.; Wark, J.D.; Weryha, G.; Marques-Neto, J.F.; Gaines, K.A.; Verbruggen, N.; Melton, M.E. Alendronic acid produces greater effects than risedronic acid on bone density and turnover in postmenopausal women with osteoporosis: Results of FACTS -international. Clin. Drug. Investig. 2006, 26, 63–74. [ Google Scholar] [ CrossRef] Zhang, J.; Wang, R.; Zhao, Y.-L.; Sun, X.-H.; Zhao, H.-X.; Tan, L.; Chen, D.-C.; Hai-Bin, X. Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis: A meta-analysis. Asian Pac. J. Trop. Med. 2012, 5, 743–748. [ Google Scholar] [ CrossRef][ Green Version] Clark, D. E. et al. The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Cancer Res. 65, 3108–3116 (2005). Cohen, M. S., Zhang, C., Shokat, K. M. & Taunton, J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308, 1318–1321 (2005). Liang, C.; Guo, B.; Wu, H.; Shao, N.; Li, D.; Liu, J.; Dang, L.; Wang, C.; Li, H.; Li, S.; et al. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy. Nat. Med. 2015, 21, 288–294. [ Google Scholar] [ CrossRef]
Wei, L.; Liu, L.; Gao, C.; Qian, C.; Xi, K.; Ruan, H.; Yu, J.; Luo, Z.-P.; Cui, W. Mechanical on-off gates for regulation of drug release in cutaneous or musculoskeletal tissue repairs. Mater. Sci. Eng. C Mater. Biol. Appl. 2020, 115, 111048. [ Google Scholar] [ CrossRef] Wingate, A. D., Campbell, D. G., Peggie, M. & Arthur, J. S. Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem. J. 393, 715–724 (2006).Ngo, L.; Knothe, L.E.; Knothe Tate, M.L. Knee Joint Tissues Effectively Separate Mixed Sized Molecules Delivered in a Single Bolus to the Heart. Sci. Rep. 2018, 8, 10254. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Yamashita, S.; Katsumi, H.; Hibino, N.; Isobe, Y.; Yagi, Y.; Tanaka, Y.; Yamada, S.; Naito, C.; Yamamoto, A. Development of PEGylated aspartic acid-modified liposome as a bone-targeting carrier for the delivery of paclitaxel and treatment of bone metastasis. Biomaterials 2018, 154, 74–85. [ Google Scholar] [ CrossRef] [ PubMed]
Writer Kenneth Turan 100 added a liner note to Wuornos’ story. The Hollywood movie about her life, Monster, won numerous, prestigious awards for acting and writing. Yet no one talked about Wuornos’ story during any award acceptance speeches. “Admittedly,” Turan wrote, “Wuornos is a tough person to thank.” However, he added, not mentioning Aileen Wuornos perpetuated the way she had been marginalized and made invisible through her struggle – a facet of her developmental history that culminated in her terrible crimes. I agree with Turan. If someone had noticed and intervened on her behalf during her tumultuous upbringings, and if her grandmother had let her get the mental health counseling she needed, maybe her life would have taken a different turn. Perhaps there would have been no string of murders along the Florida highway system. Wuornos was, from childhood, abandoned, exposed to trauma, and raped to pregnancy. She had to learn to live in the woods and on the streets. She learned violence as a coping skill.Carbone, E.J.; Jiang, T.; Nelson, C.; Henry, N.; Lo, K.W.H. Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering. Nanomedicine 2014, 10, 1691–1699. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Wang, C. Efficacy and Safety of Zoledronic Acid for Treatment of Postmenopausal Osteoporosis: A Meta-Analysis of Randomized Controlled Trials. Am. J. Ther. 2017, 24, e544–e552. [ Google Scholar] [ CrossRef] [ PubMed] BHS set out five years ago to develop the first MSK digital solution that is based on the same hands-on clinical treatment system used by professional athletic teams. In the simplest of terms, we have created a system, “YouMari”, that guides users (employees) through the MSK condition identification triage process and creating customized treatment plans to resolve those issues. These programs include the same hands-on treatments a provider would use, mobilization/stretching, exercises to strengthen the areas, and regular assessments to measure the effectiveness of the protocols and program. Tests have proven the system to be 80% effective in resolving acute MSKs without the need for a doctors’ office visit and over 90% reported a reduction in pain related to the reported issue. Pende, M. et al. S6K1 −/−/S6K2 −/− mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24, 3112–3124 (2004). And here are the really important ones to consider…people with an MSK condition are in pain, are much less happy, and less productive
Unfortunately, this is not as simple as a one size fits all program. Prevention programs must be customized to the actively level and mobility health of the individual taking into consideration their specific risk factors at work, home, and extra curricular. We have witnessed many (well-intended) stretching programs lead to injuries if not purposefully designed and moderated. Unfortunately, the wellness industry is saturated with these types of one size fits all programs with lofty claims of preventing injuries. Miyazaki, T.; Tokimura, F.; Tanaka, S. A review of denosumab for the treatment of osteoporosis. Patient Prefer. Adherence 2014, 8, 463–471. [ Google Scholar] [ CrossRef][ Green Version] A functional unit of protein synthesis that consists of several ribosomes attached along the length of a single molecule of mRNA. XEXD caspase-inhibitory box According to the National Library of Medicine of the National Institute of Health ( https://pubmed.ncbi.nlm.nih.gov/12762075/) :
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Gao, X.; Zhao, J.; Han, G.; Zhang, Y.; Dong, X.; Cao, L.; Wang, Q.; Moulton, H.M.; Yin, H. Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice. Mol. Ther. 2014, 22, 1333–1341. [ Google Scholar] [ CrossRef][ Green Version] Carriere, A., Ray, H., Blenis, J. & Roux, P. P. The RSK factors of activating the Ras/MAPK signaling cascade. Front. Biosci. 13, 4258–4275 (2008). Prior to the murders she committed at her boarding house, Puente was convicted for drugging three elderly people she met in bars and stealing their possessions. 2 She served about three years in prison, was released on parole, and took up where she left off with both of those activities and more. 3 Puente invited mentally ill, intellectually disabled, elderly, and indigent tenants in need of care and shelter to her lovely Victorian boarding house, known for its welcoming garden, on F Street in Sacramento, California. Social workers felt she was compassionate and were appreciative that she took in very difficult client cases. Dummler, B. A. et al. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J. Biol. Chem. 280, 13304–13314 (2005). of all outpatient visits are for MSKs = 558 million per year = 1.1 billion hours away from work ( S. Bureau of Labor Statistics (BLS))
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