G.COUPLER - The Original Lock-On Zerk Fitting Grease Gun G Coupler, Easy On & Off (M10x1)

Product Information

D-Type- A quite common type of keg coupler in the UK, it is known as an American Sankey as it is designed to fit nmost domestic US branded Beer Kegs It's intended that the Datum Precision coupler box is to accept a Kadee centerset coupler (e.g. having no up or down offset - coupler from the Kadee 789 or 907 kits) for mounting on the Aristo-Craft GP40 and other applications.

The Kadee description for the 907 & 1907 includes the statement ".... # 1907 #1-Scale Centerset Couplers & #911 Gearboxes"Santulli G, Trimarco B, Iaccarino G (March 2013). "G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms". High Blood Pressure & Cardiovascular Prevention. 20 (1): 5–12. doi: 10.1007/s40292-013-0001-8. PMID 23532739. S2CID 45674941. G-protein-coupled+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

G-protein-coupled receptor oligomerisation is a widespread phenomenon. One of the best-studied examples is the metabotropic GABA B receptor. This so-called constitutive receptor is formed by heterodimerization of GABA BR1 and GABA BR2 subunits. Expression of the GABA BR1 without the GABA BR2 in heterologous systems leads to retention of the subunit in the endoplasmic reticulum. Expression of the GABA BR2 subunit alone, meanwhile, leads to surface expression of the subunit, although with no functional activity (i.e., the receptor does not bind agonist and cannot initiate a response following exposure to agonist). Expression of the two subunits together leads to plasma membrane expression of functional receptor. It has been shown that GABA BR2 binding to GABA BR1 causes masking of a retention signal [60] of functional receptors. [61] Origin and diversification of the superfamily [ edit ] The cAMP signal transduction contains 5 main characters: stimulative hormone receptor (Rs) or inhibitory hormone receptor (Ri); stimulative regulative G-protein (Gs) or inhibitory regulative G-protein (Gi); adenylyl cyclase; protein kinase A (PKA); and cAMP phosphodiesterase.There are a couple of exceptions, the 906 is a combination of the 900 coupler and 910 gearbox. (basic setup for body mount) Rubenstein LA, Lanzara RG (1998). "Activation of G protein-coupled receptors entails cysteine modulation of agonist binding". Journal of Molecular Structure: Theochem. 430: 57–71. doi: 10.1016/S0166-1280(98)90217-2. Archived from the original on 16 May 2011 . Retrieved 14 January 2006. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type ( G αs, G αi/o, G αq/11, G α12/13). [6] :1160

Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, etal. (August 2016). "GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling". Cell. 166 (4): 907–919. doi: 10.1016/j.cell.2016.07.004. PMC 5418658. PMID 27499021. Joost P, Methner A (October 2002). "Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands". Genome Biology. 3 (11): RESEARCH0063. doi: 10.1186/gb-2002-3-11-research0063. PMC 133447. PMID 12429062. More recently, an alternative classification system called GRAFS ( Glutamate, Rhodopsin, Adhesion, Frizzled/ Taste2, Secretin) has been proposed for vertebrate GPCRs. [10] They correspond to classical classes C, A, B2, F, and B. [17] The G protein-coupled receptor is activated by an external signal in the form of a ligand or other signal mediator. This creates a conformational change in the receptor, causing activation of a G protein. Further effect depends on the type of G protein. G proteins are subsequently inactivated by GTPase activating proteins, known as RGS proteins. Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, etal. (November 2007). "Crystal structure of the human beta2 adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode: 2007Natur.450..383R. doi: 10.1038/nature06325. PMID 17952055. S2CID 4407117.

G Type Grundy Keg Coupler

The picture below shows how the loco's installed #1 Scale coupler aligns with a Kadee 980 gauge having the noticeably larger "G" scale coupler type. (I did not obtain the " 1929 Type E Coupler Height Gauge" meant to be used for the smaller 1/32 scale Kadee coupler.)